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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
entirely persons poor remain
The persons who remain poor are the entirely foolish, the entirely wise, the idle, the reckless, the humble, the thoughtful, the dull, the imaginative, the sensitive, the well-informed, the improvident, the irregularly and impulsively wicked, the clu John Ruskin
entire performance team
The performance of the entire team was good, Luiz Scolari
entire focus forward good looking practice ready week
We are looking forward to a good week of practice, going over some things and getting ready for Jericho. That's where our entire focus is right now. Joe Crocco
entire points second struggled
We struggled again. It was one of those nights. We only scored (seven) points the entire second half. John Gray
entire essential life projects work
For me, it's always been very essential to work on projects that one can work on almost for their entire life. Hans-Ulrich Obrist
entire festival gulf home pound
We want to pound home the idea that the festival is for the entire Gulf region. Jody Kielbasa
entire numbers ranked talked undefeated
We have never talked about being ranked No. 1 or being undefeated at all the entire season. Those numbers aren't important to us. Jim Hale
entire fans program stadium support wearing
We want our fans to show their support for our program by wearing green. We want the entire stadium in green. Mark Driscoll
entirety imagining interested kinds life looking research woman
The entirety of 'Bellocq's Ophelia' was a project, and I was interested in doing research and looking at photographs and writing about them, imagining this woman Ophelia and what her life was like and the kinds of things she thought about. Natasha Trethewey
freshmen guys last maybe older quite ready realized stand wondering
We're going to solidify a lineup. There was a lot of things that went on last weekend. We just wanted to see what guys were made of. We realized that some of the freshmen weren't quite ready yet, and I think in the same aspect, we have some older guys that maybe started wondering where they stand with the team. Robby Wine
freshmen happy hunting last looking means north people second seven top wins won year
We like being on top and we like people hunting for us, because that means we're doing things well. I'm not going to take anything away from our season. We're 24-6 and my second year -- with those freshmen that did well last year -- we had seven losses. So we're happy with where we are. North Idaho, looking back now, one of those wins would have won it for us outright. Randy Rogers
freshmen great high intensity job opponents played putting solid start veterans
This was a solid start for us. Our veterans played well and the freshmen did a great job in their first competition. They had high intensity and they did a great job of putting opponents away when they had the chance. Bill Potoczny
freshmen knew limit six sky team until
We have six freshmen on the team and they are really talented, and I knew we were going to be good, but you never know how we will do until we get out there. But potentially, the sky is the limit for this team. Thomas Kelly
freshmen guys hard listen met realize talented team
We met with the new guys on the team and made them realize you don't have to be as talented to go far. It's hard to live up to expectations. I told the freshmen not to listen and to just go out and play. Travis Buck
freshmen girls hard hitting nice taking woke
She just woke up. We've been working hard on hitting and the young girls are taking control. That's nice to see from freshmen and sophomores. Sarah Kennedy
freshmen home played
We have played only one home game. When you do that with freshmen and sophomores, this is what happens. Butch Beard
freshmen hope looking lose night pattern rough sophomore start students
The pattern we see is when students have a rough freshmen year, they come back for their sophomore year. But if they have the same pattern, they start to lose hope and start looking at other options; sometimes it?s night school, sometimes it?s a GED. Kevin Campbell
freshmen pass start three
We start with them as freshmen and tell them they have to pass it. But in their minds, two or three years is a long way off. Susan Pearson
junior space
When you think about the Space Needle, you also think about Junior rounding third. Alex Rodriguez
junior message officers send singling taking wrong
Singling out these individuals would send the wrong message to our junior officers about taking risks, Porter Goss
juniors last saw start time year
We really have a lot of experience. Our juniors saw considerable time last year and look to start as seniors. Chad Logan
junior played
I played a little basketball. Some football in junior high. Clint Eastwood
juniors played team
Tim's team played with a lot of intensity. We should have had that kind of intensity. I have 13 juniors who don't know how to see forward, yet. Alan Johnston
junior life
Here is a secret that no one has told you: Real life is junior high. Tom Brokaw
juniors matter messages
The unsaid message of that endless rack of juniors' pushup bras? No matter what size you are, it still isn't good enough. Adora Svitak
junior record senior year
My junior year was the first year in like 10 or 12 years that we had a record over .500. Then my senior year was the best, but now they're back down. Karalyn Dehn
junior playing team
I have a junior varsity team playing varsity basketball. Ed Jackson
lasts remember there-is-hope
Remember, to the last, that while there is life there is hope. Charles Dickens
lasts fool firsts
Ridicule is the first and last argument of a fool. Charles Simmons
lasts dubbing spokes
I have just returned from the dubbing studio where I spoke into a microphone as Severus Snape for absolutely the last time. Alan Rickman
last nine won
We've won nine of the last 11, so I like our chances. Eric DiBiase
last people ready year
We want to show that we're no joke. People thought last year was a fluke. We can make improvements from last year. We're ready to see what's out there. Andrew Palmer
lasts eloquent last-time
We looked at each other for the last time; nothing is as eloquent as nothing. David Mitchell
lasts records haircuts
You're only as good as your last record. David Sanborn
lasts female worship
The last western society to worship female powers was Minoan Crete. And significantly, that fell and did not rise again. Camille Paglia
lasts needs kind
I need some kind of... like... last minute, poorly-set-up deus ex machina!! Bryan Lee O'Malley
ncaa potential risk
The potential here is significant. The NCAA is at some risk. Gary Roberts
ncaa tournament win won
We're in the tournament to win it all. We won the SEC tournament, and now we want to win the NCAA tournament. Corey Brewer
ncaa prepared ready
We're ready to go and we're prepared for the NCAA Tournament. Mike Nardi
ncaa ourselves playing reason score t
We are never going to give up and we're never going t look at the score and give ourselves a reason for not playing hard. We're playing to get into the NCAA tournament. Terri Mitchell
ncaa nobody players talks
Nobody talks about the NCAA Tournament, not the players or coaches. Only you guys. Richard Midgley
ncaa officials seen surprised
I don't know that we've seen it. But the NCAA surveys everybody. I'm not surprised they surveyed the officials about us. Mike Schulze
ncaa obviously tournament
I don't know where we're going, but you've got to look up. The NCAA tournament obviously is in jeopardy. If we want to be there, then we've just got to play. Eric Devendorf
ncaa single win
To feel like we're set for the NCAA Tournament, we have to win every single game. If we don't, we're going to feel like we're on the bubble, and we don't want to be in that position. Rahshon Clark
ncaa pressure tournament worry
We can go into the (Big Ten) tournament without any worry about the NCAA tournament. There's no pressure on us. Adam Haluska
players position table
The position that's on the table by the players just isn't acceptable. Jerry Jones
players
We have so many players from New Orleans. It's always in the back of our minds. Justin Vincent
players playing starting
We're starting to do some things but we can't let up. It's a do-or-die situation, so the players are playing with a sense of urgency. Dwight Freeman
players
We're just not comfortable with our go-to players in the stretch. Mike Carey
players
We're getting better. We have players who are pretty focused. Pat Gillick
players quality signed
We know we have signed quality players - but they will need time. Thomas Doll
players
Makes a big difference. Players always make the difference. Jim Leyland
players stop takes
L.T. is fast. It takes 11 players to stop him. If 11 players are on the same page, then it's cool. But it's going to be very hard. Zeke Moreno
players skilled time
We won't be one-dimensional on offense, ... We have linemen who can give our skilled players time to make the plays. Tom Bailey
soccer air games
Speed is what makes the Premiership exciting. The millions who would have watched Manchester United and Chelsea would have seen a non-stop game in which the pace was electric even though the first half was a non-event. You could see a better technical game in Spain but for sheer frenetic movement there is nothing that comes close... Pace is more critical in the Premiership than in any other major league and if you don't have pace, you have to compensate with power or ability in the air and since Shevchenko has no power and is not particularly good in the air, he is in trouble. Alan Hansen
soccer games ships
It was the game that put the Everton ship back on the road. Alan Green
soccer winning games
This will be their 19th consecutive game without a win unless they can get an equaliser. Alan Green
soccer two cherries
Well, he had two stabs at the cherry Alan Green
soccer feet height
Here's Brian Flynn. His official height is five feet five and he doesn't look much taller than that Alan Green
soccer mark defence
A few question marks are being asked in the Honduran defence Alan Green
soccer red-and-blue people
Wembley way is beginning to blacked with people in terms of red and blue Alan Jackson
soccer football winning
Arsenal and Manchester United play the best football. They're not happy with one goal, they want to win by three. Chris Coleman
soccer gymnastics always-trying
When I've done gymnastics, ballet or soccer - I was always trying to be the best. I'm really driven. Really driven. Chloe Grace Moretz
states secretary
I loved what I did. I could've been secretary of state for ever. Madeleine Albright
states evident secretary
I loved being Secretary of State, that's probably evident to everyone who watched me. Madeleine Albright
states barometer interest
...interest is the barometer of the state... David Hume
states hyperbole constant
I live in a constant state of hyperbole. Eden Sher
states senators productive
I was very productive as a senator for my state. Carol Moseley Braun
state
We wrestled better than we did in the first. We got after the guys, and they wanted to get to the state final. Clifford Garnto
state
to play in the state in which they're franchised. Paul Tagliabue
state
We're realists. We know we're in a state where the Legislature is anti-choice. Susan Hill
state systems whether
When the state inspectors look at us, they will see that the systems are in place. You have to have a system whether you have one person or 100. Al Mollozzi
trying sometimes failing
Try to do unto others as you would have them do to you, and do not be discouraged if they fail sometimes. It is much better that they should fail than you should. Charles Dickens
trying want scripture
Dear friends, whenever you want to understand a text of Scripture, try to read the original Charles Spurgeon
trying littles reason-why
The great reason why we have so little good preaching is that we have so little piety. To be eloquent one must be in earnest; he must not only act as if he were in earnest, or try to be in earnest, but be in earnest. Charles Spurgeon
trying world term
A myth is an image in terms of which we try to make sense of the world. Alan Watts
trying world
But we try to pretend, you see, that the external world exists altogether independently of us. Alan Watts
trying way hurrying
Hurrying and delaying are alike ways of trying to resist the present. Alan Watts
trying rooms natural
That Beatle euphoria has always been there, and it's hard to be in a room with a Beatle and try to be totally natural. You never shake that off. Alan Parsons
trying entertainment television
I try to do things in comics that cannot be repeated by television, by movies, by interactive entertainment. Alan Moore
trying acting together
Improvisation sometimes seemed more like jazz than acting, like verbal jazz, with the actors playing a theme back and forth, and then introducing another theme, incorporating it, somehow trying to work their way all together to a meaning of some kind, or at least a conclusion. Alan Arkin
wonderful hypothetical
Now everything is wonderful and hazardous and nothing's hypothetical. Alan Moore
wonderful scientist interest
I'm in this wonderful position where I can do what interests me. And whatever comes along that interests me, I do. The rest of the time I bother scientists about communicating. Alan Alda
won worry
We've won here now so we don't have to worry about the 15-year thing. E. B. White
wonder-love two people
Each of us has been designed for one of two immortal functions, as either a storyteller or as a cross-legged listener to tales of wonder, love, and daring. When we cease to tell or listen, then we no longer exist as a people. Bryce Courtenay
wonder ifs
And it's the wonders I'm after, even if I have to bleed for them. Catherynne M. Valente
wonderful used many-friends
It's wonderful to meet so many friends that I didn't used to like. Casey Stengel
won
We started off very slow. We had to refocus and get back to the things that won the first set for us. Jeff Murphy
wonderful cheeky
Don't let them get you down. Be cheeky. And wild. And wonderful. Astrid Lindgren
wonderful
When or if answers are found, you can be assured those answers will lead to more questions. Is the troubling or wonderful? It depends on your view of your place in nature, your place among the stars; I suppose. Bill Nye
years needs answers
Any replacement to the current copyright position (life plus 70 years) needs to have an answer lined up for this, and similar, messy edge cases. Charles Stross
years preparation left
If I knew I had 25 years left to live, I would spend 20 of them in preparation. Charles Spurgeon
years oil alchemist
I'm a bit of an alchemist sorceress. I've collected probably 1500 oils from around the planet over the last ten years. I'm kind of obsessed with the sensuality of it. Alanis Morissette
years white black
...for thousands of years human history has been a magnificently futile conflict, a wonderfully staged panorama of triumphs and tragedies based on the resolute taboo against admitting that black goes with white. Alan Watts
years people car
Although the quality of the vehicles is tremendously improving year after year but the underlying reasons that people are buying cars have really gotten focused. It's for high quality vehicles, reliable, fuel-efficient, and safe of course. Alan Mulally
years mad people
I've known a lot of people go mad over the years, and it is more distressing than people dying. People dying is quite natural, people going mad is the complete antithesis of that. Alan Moore
years rose three
It seems strange that my life should end in such a terrible place, but for three years I had roses, and apologized to no one. Alan Moore
years style looks
It's funny, but certain faces seem to go in and out of style. You look at old photographs and everybody has a certain look to them, almost as if they're related. Look at pictures from ten years later and you can see that there's a new kind of face starting to predominate, and that the old faces are fading away and vanishing, never to be seen again. Alan Moore
years childhood arlington
I was born in Somerville, but I don't remember very much about it because we moved from there to Arlington when I was five years old, and it was in Arlington that I spent most of my childhood. Alan Hovhaness