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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics.
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online.
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services.
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts.
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters.
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here,
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof.
cannot conflicts parliament solved strengthen
We want to strengthen democracy. When conflicts cannot be solved in parliament they should be solved by citizens. Jaroslaw Kaczynski
cannot democracy island regime send signal strong surrounded
We want to send a strong signal to the regime in Swaziland that it cannot be an island surrounded by democracy in the region.
cannot cause continue including received spur ted work
Much like the conservationists who previously have received the Audubon Medal, including Stewart Udall, Rachel Carson and Ted Turner, I realize that this recognition cannot be a cause to rest, but a spur to continue our work. Louis Bacon
cannot dream
You cannot kill a breeze, a wind, a fragrance; you cannot kill a dream or an ambition. Michel Onfray
cannot empty fathom good players souls stories tried whatever work
Players would empty their souls to me; you cannot fathom the stories I've heard, everything from the good to the bad. I tried whatever I could to work things out. Morgan Wootten
cannot choices choose deeply inspirational life today until
Until a person can say deeply and honestly, I am what I am today because of the choices I made yesterday, that person cannot say, I choose otherwise.
cannot choice choices choose deeply otherwise today until
Until a person can say deeply and honestly, "I am what I am today because of the choices I made yesterday," that person cannot say, "I choose otherwise
cannot clearer congress count domestic help house looking remedy totally white
We are looking to Congress, ... It is clearer than ever that America's domestic manufacturers cannot count on any help from the White House to remedy this totally unacceptable situation.
cannot ensure forget happened remember side
We are at their side as they suffer. One cannot forget what happened and one must remember to ensure it does not happen again.
decisive europe factor feelings future influenced national whether
The decisive factor for the future of Europe - and before all things, for the 'restoration' of Europe - will be whether political thought and national feelings are influenced by the reality of internationalism. Ellen Key
decisive issues needs politics reform
The real reform Japan needs is decisive politics when we face issues that need to be decided. Yoshihiko Noda
decisive tense
We were a little tense in the first half, which I hadn't been expecting, but we were more decisive after the break.
decisive effort expect match maximum players reserve
I expect maximum effort from my reserve players because this kind of match will be decisive for our season. Manuel Pellegrini
decisive enjoyed enjoying good nobody players thinks win
I enjoyed it when we were the favorites. I'm enjoying us being decisive underdogs, because nobody thinks we'll win this series. So, yeah, I'm enjoying it. I've enjoyed it all. What I'd like to do is see our players play as good as they can play.
decisive either lead
There is no decisive lead for either side.
decisive northern played role
The paramilitaries played a decisive role in this election, particularly in the northern part of the country.
decisive goal time victory wage
Our goal is victory. It's time to wage a decisive battle. Atal Vajpayee
decisive elections honest qualities
I think these qualities will be decisive during presidential elections in 2000, ... decent, honest and thorough. Boris Yeltsin
designs keeping
We're keeping it to just one day because the quilts are so old and valuable. Some of the designs are really unusual.
designs developing european foreign franklin human nations nuclear united
Most Americans have no memory of the designs Franklin Roosevelt's New Dealers had for postwar-American foreign policy. Human rights, self-determination and an end to European colonization in the developing world, nuclear disarmament, international law, the World Court, the United Nations - these were all ideas of the progressive left.
designs outside since states toward united
It has been a long while since the United States had any imperialistic designs toward the outside world. But we have practised within our own boundaries something that amounts to race imperialism. Wendell Willkie
designs fall favorite hair memory particles watching
My favorite memory in the barbershop was watching the hair fall. Little particles would fall and I would make designs out of it. Jenifer Lewis
designs looking modes reservoir rest surrounded time trying
I'm in two modes when I'm on Lanai: In engineering mode, I'm trying to find the right place for the reservoir and the desalination plant, and looking at designs for new hotel rooms. The rest of the time, I'm in decompression mode. I'm on Hulopoe Beach, going for a swim, or on my paddleboard surrounded by 100 spinner dolphins. Larry Ellison
designs extra home offer space variety
We offer a lot of extra space in our home designs that can be used for a variety of purposes.
designs parts people plan relative rich
People here are really wedded culturally and emotionally to very rich plan designs relative to what you see in different parts of the country. They are just more expensive. Charles Baker
designs game road
Most designs take years. But it was very important for them to get back in the game and have a road map.
designs explore follow great nickel pieces small thomas vision
The 2005 nickel designs follow Thomas Jefferson's vision to explore the great West, ... small pieces of contemporary art.
devices
We are making a lot of enhancements to devices specifically for enterprises,
devices digital enabling fight form maybe number people portable survival technology theaters within
We're in a fight for survival here. Maybe we just need to fight back harder, come out blazing, not wither away and die. D-cinema can do it, for a number of reasons, but because d-cinema is an enabling technology for 3-D. Digital 3-D is a revolutionary form of showmanship that is within our grasp. It can get people off their butts and away from their portable devices and get people back in the theaters where they belong. James Cameron
devices wells vocal
Well, I happen to have a love of vocal reproduction devices. Billy West
devices open shows somewhat stage tape technical throughout using various
I first started doing some somewhat technology-based shows in the '80s. If you wanted to get real technical about it, back in the '70s I used to open up with Utopia with just me on the stage with a four-track tape recorder. So, technically, I've been using the help of various devices pretty much throughout my career. Todd Rundgren
devices interact life matter systems technical technology work
No matter how non-technical your life and work, you're going to have to interact with technology and technical people. If you know something about how devices and systems operate, it's a big advantage. Brian Kernighan
devices experts mechanism mind work
We're beautiful devices. The devices work well; we're all experts in what we do. But when the mechanism fails, those failures can tell you a lot about how the mind works. Daniel Kahneman
devices engineered imaging people photos recognize separate
We recognize that some people don't want to have separate imaging devices for their photos and video. Our new Cyber-shot has been specifically engineered for these people. James Neal
devices distract essence humanity increase machines man noise passed soon technology turned
Soon silence will have passed into legend. Man has turned his back on silence. Day after day he invents machines and devices that increase noise and distract humanity from the essence of life, contemplation, meditation. Jean Arp
devices disney gives means move opportunity reach technology walt
Our company has been very forward-thinking about digital technology and the opportunity that it gives us. As we move into a world where we have more and more devices at our disposal, that really means more and more opportunities for the Walt Disney Co. to reach you: through our entertainment, through all of our divisions. Anne Sweeney
forces plans present rule time
We're not going to rule out anything, but we don't have any plans at the present time to use U.S. forces in that way, Donald Rumsfeld
forces listened music radio
When I was a kid,if you were lucky, you listened to that music on Radio Luxembourg or the American Forces Network. Georgie Fame
forces particles
Investigating the forces that hold the nuclear particles together was a long task. Richard P. Feynman
forces prey
I know how tough it is to stand up to powerful forces that prey on consumers. Kathleen Sebelius
forces four game position
When you put yourself in the position to have to come back like that it forces your hand. You have to make every play and you can't make a mistake. But the story of this game was told in the first four minutes.
forces huge move present pressure puts tough
She puts huge pressure on me. She is so present on the court. She really forces you back. It's tough to get the rallies going and move her around. Patty Schnyder
forces helped medical provide scene support urgent
What I can say is that U.S. forces helped to provide urgent medical support at the scene of the incident, something for which I know our forces are grateful,
forces respond security strength terrible
Security forces must respond with strength to the terrible attack.
forces harness might various
If you are a Representative and want to be a Senator, you must be careful not to do anything which might upset the various forces you need to harness to get elected. Gore Vidal
initial steps
We have initiated an investigation because we feel there were some discrepancies that we have encountered, but right now we're in the initial steps of the investigation.
initial requires
I think a child requires initial years of a mother's attention, which is very important, and I did it without any thought in the world. That's what I wanted to do. Karisma Kapoor
initially large percent three twice whether
We don't know whether it'll be twice as large or three times as large or 50 percent as large as we initially planned.
initial matter talking walk whether
On the initial accreditation it was a matter of whether we?re talking the talk. Now, it?s can we walk the walk?
initial matter talking walk whether
On the initial accreditation, it was a matter of whether talking the talk. Now its can we walk the walk,
initially leading
Much of what was said was initially said by the cooperating witness, ... It was leading questions. Johnny Griffin
initial
My initial thought was that I was going to try out for the team.
initial move phase reaction simplify took
My initial reaction was, 'What took them so long?' ... They had too many brands, too many fiefdoms, and they had to simplify it. Even after they phase out Oldsmobile, they'll have too many, but I don't see them making another move for the foreseeable future. David Healy
initial less reaction television
My initial reaction was, I couldn't be less interested. I thought, I'm going to do more television. Why would I do Internet? Harvey Levin
mechanical plane sat seattle sent waited
The plane to Boise had some kind of mechanical problem; we were actually on the plane before they sent us back. And then we just sat and waited and there was no other way to get us to Boise, so they sent us to Seattle and put us up for the night.
mechanical pencils tips
My problem with mechanical pencils is that I break the lead tips constantly. Mark Frauenfelder
mechanical mechanics
I like mechanical things; my first book was a mechanics guide - that was what my parents couldn't pry away from me; that was the blanket. Philipp Meyer
mechanical tough
It was a tough day for us because of mechanical problems.
occupying time
I was writing and I have three kids. I was occupying my time with them but it was difficult. Alison Moyet
planes
The planes were very old. I think the plane was overworked.
planes
My focus on 9/11 was on the victims - in the towers, in the planes - and all that loss. Kiefer Sutherland
planes shot
One of every 16 planes was shot down, Lyndon Johnson
planes hard
Getting on a plane is hard for me, but I do it, because travel is vital to me. Amanda Lindhout
planes paratroopers parachutes
In Italy the Coach is a paratrooper who jumps out of the plane but doesn't know if the parachute will open or not. Claudio Ranieri
planes ifs knows
I don't know if anyone will ever sit beside me on a plane again. Cillian Murphy
planes sensitive
I think when you first come out here, you're very sensitive to planes overhead. Michael Chang
planes
Without planes I wouldn't be able to do what I do. Kelly Holmes
planes safer struck today trade
no safer today than the day the planes struck the World Trade Center. Howard Dean
victory events defeat
In times of defeat, we never know how close we are to victory. In every event of failure, God has planted a seed of success. Charles Stanley
victory needs conflict
Victory needs conflict as its preface. Charles Spurgeon
victory battle sometimes
The manner in which one loses the battle can sometimes outshine the victory. David Millar
victory ordinary accepted
Once any tyranny becomes accepted as ordinary, its victory is assured. David Mitchell
victory saws
I came, saw, and overcame. William Shakespeare
victory events campaigns
You should never even ask if a campaign is winnable, because the question is not answerable. No-one can predict the course of the future. Time and time again I have seen completely unforeseeable shifts in the tide of events that result in campaign victory. Elizabeth May
victory spirituality
Our victory rests not on faith in our spirituality. Our victory rests on faith in our God. Beth Moore
victory battle hotter
The hotter the battle the sweeter the victory. Bob Marley
victory
Victory is produced by and belongs to all. Bill Walsh
war ambition mean
For what are the triumphs of war, planned by ambition, executed by violence, and consummated by devastation? The means are the sacrifice of many, the end, the bloated aggrandizement of the few. Charles Caleb Colton
war winning games
War is a game in which princes seldom win, the people never.
war hands fog
Mystery magnifies danger, as a fog the sun, the hand that warned Belshazzar derived its horrifying effect from the want of a body.
war writing fighting
Men will wrangle for religion, write for it, fight for it, die for it; anything but live for it.
war long body
Wars are to the body politic, what drams are to the individual. There are times when they may prevent a sudden death, but if frequently resorted to, or long persisted in, they heighten the energies only to hasten the dissolution.
war heart character
Why am I always at war with myself? Why have I told, as if upon compulsion, what I knew all along I ought to have withheld? Why am I making a friend of this woman beside me, in spite of the whispers against her that I hear in my heart? Charles Dickens
war believe blow
I believe that the heaviest blow ever dealt at liberty's head will be dealt by this nation in the ultimate failure of its example to the earth.
war believe writing
There's a long-standing (50 year old) flame war within the field over whether it's "sci-fi" or "SF".SF has traditionally been looked down on by the literary establishment because, to be honest, much early SF was execrably badly written - but these days the significance of the pigeon hole is fading; we have serious mainstream authors writing stuff that is I-can't-believe-it's-not-SF, and SF authors breaking into the mainstream. If you view them as tags that point to shelves in bricks-and-mortar bookshops, how long are these genre categories going to survive in the age of the internet? Charles Stross
war writing spy
I like lassic British spy thrillers. Seriously. If the cold war was still on, that's something I'd be writing.
winter darkness scrooge
Darkness is cheap, and Scrooge liked it.
winter age lapland
Cheerfulness ought to be the viaticum vitae of their life to the old; age without cheerfulness is a Lapland winter without a sun.
winning race looks
If we look backwards to antiquity it should be as those that are winning a race.
wine order water
In order to try whether a vessel be leaky, we first prove it with water before we trust it with wine.
wings gone originality
All the poets are indebted more or less to those who have gone before them; even Homer's originality has been questioned, and Virgil owes almost as much to Theocritus, in his Pastorals, as to Homer, in his Heroics; and if our own countryman, Milton, has soared above both Homer and Virgil, it is because he has stolen some feathers from their wings.
wind literature wave
Commerce flourishes by circumstances, precarious, transitory, contingent, almost as the winds and waves that bring it to our shores.
wind fire tale-of-two-cities
Then tell Wind and Fire where to stop," returned madame; "but don't tell me.
winning race obstacles
Ride on! Ride on over all obstacles and win the race.
wine paris six
Along the Paris streets, the death-carts rumble, hollow and harsh. Six tumbrils carry the day's wine to La Guillotine.