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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
baseball growing-up book
I didnt really grow up a comic book fanatic. I was a big baseball player, and my passion in life, in third grade, was collecting baseball cards. That was my childhood thing. Alan Ritchson
baseball kids player
I wanted to be a baseball player, naturally, but I wasn't good enough. I didn't know what I was going to do with my life. I just had a kind of energy, I was a fairly happy kid. Al Pacino
based behalf business customers decisions field includes line operating personnel regional responsibility restaurant ultimately
We want the line -- which for McDonald's includes our divisional and regional staffs, owner/operators and restaurant personnel -- to make decisions on behalf of customers based on field operating needs. The line ultimately has responsibility and accountability for our business success, Jack Greenberg
base fabulous fan football great
We want to see football in Ottawa. It's a great fan base and has some fabulous potential. But having said that, there's also reality. Ken Hildahl
baseball fun missing
If you're not having fun in baseball, you miss the point of everything. Chris Chambliss
baseball gone home-run
Back, back, back, back... Gone! Chris Berman
baseball hate yankees
Here at NBC there is just one more reason to hate the Yankees. Chet Huntley
baseball school games
I'm a very competitive person, whether it's school, baseball or even playing video games. David Price
baseball winning player
My goal on Earth is not to win a World Series or be the best baseball player who ever lived. That simply is not up to me because I have to wait and see if it is part of the Lord's plan. My goal is to follow the Lord and what he wants me to do so that someday I may enter His kingdom and receive everlasting life. David Murphy
broadway film made
If, for instance, we'd made the film after the show had been to Broadway, it would have been exactly the same film but we would have been assured that they would have understood it. We didn't have to do any alterations for Broadway. I was supposed to go a fortnight before it opened to alter anything that was necessary and there was nothing really. Alan Bennett
broadway certainly community focus good job open people plan side west
We want to tell people that we plan to focus on doing a good job on the west side of Broadway. If the community agrees that we should focus west of Broadway it will certainly help. If they don't, we're certainly open to any other ideas. Don Harris
broadway cups titles
I am a collector of many things, but I particularly love the sterling silver mint julep cups, each engraved with the titles of the Broadway shows in which I appeared. Bryan Batt
broaden delighted democrats liberal party positive supported work
The positive is I'm delighted at the way the Liberal Democrats as a party have supported me and the way in which the work I'm doing, through the Liberal Democrats, has abled to broaden some of the work I work on. Maajid Nawaz
broader choice expand greater investment investors keen listed markets opportunity pleased products provide range represent trust trusts various wanting welcome
We are pleased to welcome Witan Investment Trust plc to the NZSX Market. NZX is keen to see a broader range of products listed on our various markets to provide greater choice for investors wanting to expand their investment horizons. Listed Investment Trusts are such products; and represent a great opportunity for investors to diversify their portfolios. Geoff Brown
broadband content continue customer customers gets gorilla number paid per revenue roll ultimately
We still think content is really going to be ultimately what gets paid for on the Internet, and this is the big gorilla of content already, ... And as we see them roll out broadband more ... you'll see the revenue per customer go up and you'll continue to see the number of customers increase. Michael Murphy
broadband covered major segment
We covered every major segment of this broadband communications world. Henry Samueli
broaden deal energy environmental human knowledge laws nature peace population poverty problems understanding
To deal with these problems - of world population and hunger, of peace, of energy and mineral resources, of environmental pollution, of poverty - we must broaden and deepen our knowledge of nature's laws, and we must broaden and deepen our understanding of the laws of human behavior. Herbert A. Simon
broadway-theatre people groups
I coach young people. I have a group called BTP - Broadway Theatre Project. Ben Vereen
continuing council gave hopeful people pleased reception stay washington work
We want to stay in Washington. We're very pleased with the reception that people in Washington gave to the team. We're continuing to work with the mayor, we're continuing to work with the council and we're hopeful that we can get it done. Bob DuPuy
continuing operations point within
The point of this whole thing is to look at your continuing operations within your infrastructure. Rich DiPentima
continuing ethanol improvement innovation plant proud showcase welcome
We are proud to welcome Corn, LP as the 21st ethanol plant in Iowa. This plant is a showcase of the continuing innovation and improvement in the ethanol industry. Monte Shaw
continuing dialogue hoping resolved soon
We're in continuing dialogue and we're hoping it'll be resolved as soon as possible. Giles Morgan
continuing days economic four group last meetings monday negotiate resume review sides small spent various
We spent the last four days in small group meetings continuing to review and negotiate various systemic and economic issues. The two sides will resume small group discussions on Monday in Toronto. Ted Saskin
continuing government guard national pursue wrong
Where is our National Guard when we need them? Theyre over in Iraq, ... Why is our government continuing to pursue the wrong priorities? Diane Forden
continuing incident intention
We have no intention to let this incident preclude us from continuing those flights. Bob Graham
continuing-to-learn games names
The name of the game is continuing to learn. Even if you're very well trained and have some natural aptitude, you still need to keep learning. Charlie Munger
continuing mining related theme
This theme is continuing and not just in the mining stocks, but in any related sectors. This is a macroeconomic trend. Jim McCafferty
economics taxes
Whatever you tax you get less of. Alan Greenspan
economics paying
Sometime, while I wasn't paying attention, trickle-down economics got respectable. Timothy Noah
economics issue last margins number primarily problem profit reduction vaccines
The problem with vaccines is not a new problem, ... For the last decade, we have had reduction in the number of vaccine manufacturers. ...The issue comes down primarily to economics ... Profit margins are small. Mitchell Cohen
economics formal nobel prize
I think it is true to say that I am not the first Nobel Prize winner in economics to have little formal training in economics. Clive Granger
economics economists work
You know and I know and economists know that trickle-down economics doesn't work. Dannel Malloy
economics hundred labor
A hundred times every day I remind myself that my inner and outer life are based on the labors of others. Albert Einstein
economics economy-and-economics field forecasts happen happening remember rules whatever
One of the soundest rules I try to remember when making forecasts in the field of economics is that whatever is to happen is happening already Sylvia Porter
economics economy-and-economics remember support
But we've got to remember the economics have to be there to support it, George Shinn
economics economy deficit
The federal budget deficit is the biggest single impediment to revitalizing the American economy. Alice Rivlin
formal terrible settings
I'd make a terrible practitioner of any religion in any formal setting. David Knopfler
formal motto
We don't have any formal motto this year. Dieter Kosslick
formal given refute rights
We feel that his due-process rights were violated. He was never given a formal hearing, he was never given a right to refute anything. Michael McDermott
formal people
There are people who think this is a more formal place, for holidays. Karen Henderson
formal hold police qualified side somebody together tying work
Somebody could be in police work for umpteen years and doesn't have the formal side of the training, yet is very qualified to hold the job. This would be a way of tying the two together in a way that is fair. David Hamm
formal mistake statement
We're acknowledging that a mistake was made on the play. We don't have a formal statement on it. John Paquette
formal joined members offers solidarity
Solidarity members joined in at midnight. There are no formal offers at this point. Reint Dykema
formal listening love mother picked
I love to sing. I never had any formal training. My mother is a singer, and I picked up listening to her. Nimrat Kaur
formal straight tuxedo wear
You're dressed in a tuxedo, you wear a bow tie. A bow tie with a tuxedo is more formal than a straight tie with a tuxedo. Bill Nye
gains action terrorism
If we allow terrorism to undermine our freedom of action, we could reverse at least part of the palpable gains achieved by postwar globalization. It is incumbent upon us not to allow that to happen. Alan Greenspan
gains potential returns
The potential returns for BHP are enormous, even after the gains recently. Richard Wallace
gains opportunity selling
The post-auction gains were used as a selling opportunity. Kim Rupert
gains applause harder
It is harder to avoid censure than to gain applause. David Hume
gains facts celebration
It is a psychological fact that we cherish most what we have worked hardest to gain. The further we have come, the sweeter the celebration at the destination when we arrive. Denis Waitley
gain ground playing points teams western
We have to get as many points as can right now. We have to get some separation. We have a lot of teams playing each other in the Western Conference. We are going to gain some ground on someone. Barry Trotz
gain hear identity starting
We're starting to gain an identity and confidence. We're starting to build. You can hear it in the banter on the bench. Ken Hitchcock
gains increases seeing split wage
We're seeing the productivity gains split up between wage increases and profits. Scott Brown
gained supposed
I've gained fans, fame, fortune, but I don't feel different. Am I supposed to? Kristin Cast
knowledge men order
Men are more readily contented with no intellectual light than with a little; and wherever they have been taught to acquire some knowledge in order to please others, they have most generally gone on to acquire more, to please themselves. Charles Caleb Colton
knowledge simplicity complicated
The further we advance in knowledge, the more simplicity shall we discover in those primary rules that regulate all the apparently endless, complicated, and multiform operations of the Godhead. Charles Caleb Colton
knowledge class ferns
In the pursuit of knowledge, follow it wherever it is to be found; like fern, it is the produce of all climates, and like coin, its circulation is not restricted to any particular class. Charles Caleb Colton
knowledge performances pretension
The highest knowledge can be nothing more than the shortest and clearest road to truth; all the rest is pretension, not performance, mere verbiage and grandiloquence, from which we can learn nothing. Charles Caleb Colton
knowledge discovery views
It has been observed that a dwarf standing on the shoulders of a giant will see farther than the giant himself; and the moderns, standing as they do on the vantage ground of former discoveries and uniting all the fruits of the experience of their forefathers, with their own actual observation, may be admitted to enjoy a more enlarged and comprehensive view of things than the ancients themselves. Charles Caleb Colton
knowledge pay despise
To despise our own species is the price we must often pay for knowledge of it. Charles Caleb Colton
knowledge perfect brain
The seat of perfect contentment is in the head; for every individual is thoroughly satisfied with his own proportion of brains. Charles Caleb Colton
knowledge science two
Knowledge is two-fold, and consists not only in an affirmation of what is true, but in the negation of that which is false. Charles Caleb Colton
knowledge world lifts
Let no knowledge satisfy but that which lifts above the world, which weans from the world, which makes the world a footstool. Charles Spurgeon
latter matter matters says speech three
Three things matter in a speech - who says it, how he says it and what he says, and of the three, the latter matters the least John Morley
latter mitchell split thursday tough visited
I thought we would have probably split with Sickles and Countryside (the latter of which visited Mitchell on Thursday night). It's a tough district. Scott Bisbe
latter marked piece taking
I always marked up a piece of paper before taking a job, looking at the pluses and minuses. If the latter outnumbered the former, I would pass. Dennis Washington
latter period steadily tendency
In the period from 1824 to 1833, the tendency was steadily in the former direction, but it was only in the latter part of it that it was made really efficient. Henry Charles Carey
latter estates careful
Be more careful of your conscience than of your estate. The latter can be bought and sold; the former never. Hosea Ballou
latter life running viable
The joke I always make is I'm either running for reelection, running for Senate, running for governor, or running for my life. The latter is also a viable possibility. Cory Booker
latter
He's progressing, getting back to form. He's not where he should be right now, but he could be by the latter part of the week. Bill Callahan
latter former determine
Being and time determine each other reciprocally, but in such a manner that neither can the former - Being - be addressed as something temporal nor can the latter - time - be addressed as a being. Martin Heidegger
latter distasteful
As between the intolerable and the merely distasteful, I must choose the latter. Rex Stout
political appearance
Keep up appearances whatever you do. Charles Dickens
political preparation political-life
Sudden shifts and changes are no bad preparation for political life. Charles Dickens
political liquid kind
If you're going to have any kind of political opposition in the 21st century, then it has to be as fundamentally liquid as the rapidly changing society we're living in. Alan Moore
political groups social
If you get beyond the political rhetoric [and assembled a group to solve Social Security] it would take them 15 minutes. It would take them 15 minutes only because 10 minutes was used for pleasantries. Alan Greenspan
political campaigns maps
Here's what I know about political campaigns: no matter what you map out at the beginning, it's always different at the end. Chris Christie
political judgment operations
If I cannot trust someone's judgment, I cannot ask others to do so, and I would not place him at the head of my political operation. Chris Christie
political way platforms
I used to do some philanthropic work, but with the political platform, I can contribute in a bigger way. Chiranjeevi
political thinker
I'm not a great deep political thinker. David Mitchell
political influence economic
Economic and political structures that have a far sweeping impact on the lives of billions is not outside the purview of the gospel's redemptive influence. David Kim
reasonable
We're going to go to something that is a reasonable rate. Dave Scott
reasonable
Anybody with a reasonable income can become financially independent in a lifetime. Thomas J. Stanley
reasonable vice
It is the function of vice to keep virtue within reasonable bounds. Samuel Butler
reasonable testing
only when no other reasonable alternative testing methodology exists. Philip Morris
reasonable somebody success winning
I would say it has to be somebody who's a veteran, who's an innings-(eater) who's had reasonable success on a winning team. Brian Sabean
reasonable speeds switch
I switch off lights like a maniac. I drive at reasonable speeds so that I don't waste petrol. Joanna Lumley
reasonable
I think it's a reasonable model. It eliminates flakiness of patching and upgrading software. Jeff Tarter
reasonable strong support
I think we have come to a reasonable consensus. I think it will have strong support in the Senate. Sen Sears
reasonable
I think that's reasonable over time, but it's not going to come easily. Robert Buchanan
science uniforms taste
In science, reason is the guide; in poetry, taste. The object of the one is truth, which is uniform and indivisible; the object of the other is beauty, which is multiform and varied. Charles Caleb Colton
science disorder cures
No disorders have employed so many quacks, as those that have no cure; and no sciences have exercised so many quills, as those that have no certainty. Charles Caleb Colton
science mind cost
The acquirements of science may be termed the armour of the mind; but that armour would be worse than useless, that cost us all we had, and left us nothing to defend. Charles Caleb Colton
science tolerance religion
We are not clear as to the role in life of these chemicals; nor are we clear as to the role of the physician. You know, of course, that in ancient times there was no clear distinction between priest and physician. Alan Watts
science judging hammers
What happens if a big asteroid hits Earth ? Judging from realistic simulations involving a sledge hammer and a common laboratory frog, we can assume it will be pretty bad. Dave Barry
science animal mph
Scientists tell us that the fastest animal in the world, with a speed of 120 mph, is a cow dropped out of a helicopter. Dave Barry
science simple water
Here's a simple experiment that you might want to try if there is absolutely nothing else going on in your life. All you need is a cork, a bar magnet, and a pail of water. Simply attach your magnet to your cork, then drop it into the water, and voilà (literally, "you have a compass")-you have a compass. How does it work? Simple. Notice that, no matter which way you turn the bucket, the cork always floats on top of the water (unless the magnet is too heavy). Using this scientific principle, early hardy mariners were able to tell at a glance whether they were sinking! Dave Barry
science years careers
I ... began my career as a wireless amateur. After 43 years in radio, I do not mind confessing that I am still an amateur. Despite many great achievements in the science of radio and electronics, what we know today is far less than what we have still to learn. David Sarnoff
science oxygen breathe
Freedom is the oxygen without which science cannot breathe. David Sarnoff
self words-of-wisdom crowns
All other swindlers upon earth are nothing to the self-swindlers, and with such pretences did I cheat myself. Surely a curious thing. That I should innocently take a bad half-crown of somebody else's manufacture, is reasonable enough; but that I should knowingly reckon the spurious coin of my own make, as good money! Charles Dickens
self cells knaves
Alas! how has the social spirit of Christianity been perverted by fools at one time, and by knaves and bigots at another; by the self-tormentors of the cell, and the all-tormentors of the conclave! Charles Caleb Colton
self abuse doe
He that abuses his own profession will not patiently bear with any one else who does so. And this is one of our most subtle operations of self-love. For when we abuse our own profession, we tacitly except ourselves; but when another abuses it, we are far from being certain that this is the case. Charles Caleb Colton
self order should
Self-love, in a well-regulated breast, is as the steward of the household, superintending the expenditure, and seeing that benevolence herself should be prudential, in order to be permanent, by providing that the reservoir which feeds should also be fed. Charles Caleb Colton
self-esteem war loser
We are sure to be losers when we quarrel with ourselves; it is civil war. Charles Caleb Colton
selfish character men
Old Mr. Rarx was not a pleasant man to look at, nor yet to talk to, or to be with, for no one could help seeing that he was a sordid and selfish character, and that he had warped further and further out of the straight with time. Charles Dickens
selfish heart character
Notwithstanding his very liberal laudation of himself, however, the Major was selfish. It may be doubted whether there ever was a more entirely selfish person at heart; or at stomach is perhaps a better expression, seeing that he was more decidedly endowed with that latter organ than with the former. Charles Dickens
self ecosystems space
I'd like to be proven wrong firstly on the difficulty of building a self-sustaining closed circuit ecosystem in space that can support human life. Charles Stross
self trouble needed
What is needed is not the removal of the trouble but the conquest of self. Charles Spurgeon
skills honey taste
Most plagiarists, like the drone, have neither taste to select, industry to acquire, nor skill to improve, but impudently pilfer the honey ready prepared, from the hive. Charles Caleb Colton
skills generations novelists
We're currently living with a generation of established novelists who are embarrassingly out of date with respect to social networking, internet skills, and so on. Charles Stross
skills perception taoism
But the transformation of consciousness undertaken in Taoism and Zen is more like the correction of faulty perception or the curing of a disease. It is not an acquisitive process of learning more and more facts or greater and greater skills, but rather an unlearning of wrong habits and opinions. As Lao-tzu said, "The scholar gains every day, but the Taoist loses every day. Alan Watts
skills age lucky
And the maestro surely wielded the chairman's baton with extraordinary skill. His stellar record suggests that the only right answer to the age-old question of whether it is better to be lucky or good may be: both. Alan Blinder
skills cards world
I don't know if this is an illusion but I would love to be able to take my card-throwing skills and be able to puncture a watermelon. Now I know I can take this question and say, "I would want to solve the economic problems in the world" - but I want to stick that card in that watermelon. Dave Franco
skills judging-yourself luck
Don't confuse luck with skill when judging others, and especially when judging yourself. Carl Icahn
skills class looks
You've got to look and pick your shots - and that's where your class and skill comes out. Billy Joe Saunders
skills mind soil
In the productions of the mind, as in those of the soil, the gifts of nature are excelled by industry and skill . . . Edward Gibbon
skills energy kind
Picasso is still influencing me. Of course, I haven't got that kind of energy, or skill. David Hockney
symbolic-meaning perception tragedy
The popularity of disaster movies expresses a collective perception of a world threatened by irresistible and unforeseen forces which nevertheless are thwarted at the last moment. Their thinly veiled symbolic meaning might be translated thus: We are innocent of wrongdoing. We are attacked by unforeseeable forces come to harm us. We are, thus, innocent even of negligence. Though those forces are insuperable, chance will come to our aid and we shall emerge victorious. David Mamet
symbolic
We wanted it to be local. We wanted it to be symbolic of our own difficulties in life. Tony Morris
symbolic york
Now I think New York is symbolic of the nation's division. Bill Schneider
symbolic
It would be a symbolic contribution, not compensation. Wolfgang Bosbach
symbolic
It was a symbolic need for us to be out front, because it was our kid, Stephanie Bennett
symbolic-meaning people looks
People who look for symbolic meaning fail to grasp the inherent poetry and mystery of the images. Rene Magritte
together tools use
Logic and metaphysics make use of more tools than all the rest of the sciences put together, and do the least work. Charles Caleb Colton
together ships speed
God works all things together for your good. If the waves roll against you, it only speeds your ship towards the port Charles Spurgeon
together world letters
...mysticism and empiricism go together in opposition to scholasticism...they base themselves on the non-linear world of experience rather than the linear world of letters. Alan Watts
together buffets throwing
Stop throwing us all together like some sort of Puerto Ricaminican Tex-Mex buffet. Al Madrigal
together too-much sides
When you put relative and absolute truth together and they become one unit, it becomes possible to make things workable. You are not too much on the side of absolute truth, or you would become too theoretical. You are not too much on the side of relative truth, or you would become too precise. When you put them together, you realize that there is no problem. Chogyam Trungpa
together pieces narrative
When I worked with Woody Allen, I only got the parts of the script that I was in. I was able to piece together the narrative from that, but I remember being quite excited to watch the movie - the movie that I was in but didn't know what happened in, like, 65 percent of. Chiwetel Ejiofor
together energy making-changes
We are one energy. Together we can make a change. David Guetta
together states anthropology
Anarchism and anthropology go well together because anthropologists know that a society without a state is possible because so many exist. David Graeber
together grandson
And then there's my Grandson: He's certainly got the music together, there's just no question about it. Cab Calloway