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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
apply coaching happened opened people position social staying studies successful teach teaching
The position that opened up happened to be a social studies position. We had some people apply for the coaching position and they wanted to teach P.E. We had some other people apply just for the teaching position. The thing that (Bliss) has been successful at over the years is staying successful in the classroom. Debra Rhymer
applying available control folks help results start technology
There are some end results that show some folks could start applying technology that, frankly, is available to help control some of the emissions. Wayne Gieselman
applying business component costs customers design easier enhancing entire internet process reducing relationships
We're increasingly applying the Internet to our entire business, from component design to end-user support, in the process making it easier to do business with Dell, enhancing relationships with customers and suppliers and reducing costs for all of us, Michael Dell
apply band connected inspires life society teach watching
You should be watching 'Red Band Society' because it's a show that inspires us to live. I feel like you'll get connected to these characters, and they teach you something that you can apply to your daily life. Nolan Sotillo
apply economic help rule standing steal towns
We always had a standing rule on economic development that towns didn't steal from each other. If they were going to do that, they didn't get any help from the state. I think the same thing should apply here. Mike Blouin
apply call family hope income lock maybe months national principle six time waiting year
You don't lock into a ten-year family budget. You take it a year at a time - maybe even six months at a time. And then if the income really comes in the way you hope it does, then you can make some of those expenditures that you've been waiting to make. We think that same principle should apply to the national family we call America. Dick Gephardt
apply businesses information leave light looking money people reasonable saying small stack standards walk
What we're looking for is to have small businesses apply standards that are reasonable in light of the information that they're storing. There's no business around that would leave a stack of money on a table, for people to just walk in and take. What we're really saying is that information about consumers, about your customers, is the new currency. Lydia Parnes
apply department housing money plumbing systems urban wants work
What they want the communities to do is apply for the work they will do. HUD (the Department of Housing and Urban Development) wants to know how many roofs, how many plumbing systems and how many furnaces were replaced. There's a lot of money being spent, but no accountability. Paul Tecpanecatl
apply box game good practice
We can do all the drills in the world, but we have to apply it in the game. We look so good in practice doing them, then we come out in the game and it's not the same. ... We have to rebound. We have to box out on every play. We have to do the little things. Tre Kelley
budgets certainly comedies low
Most of my comedies were low on budgets - certainly by American standards. Norman Wisdom
budgets companies dedicated double fewer large regardless smaller
What makes it a problem, regardless of why, is that smaller companies are the ones who have fewer defenses in place. There are no large dedicated IT staffs in place, or large budgets for technology, so it's a double whammy. Andrew Lochart
budgets confident rate works
We're confident we can get a rate that works in the 2006 budget, Tom Leighton
budgets clear decisions faces helps kids leaves less time today visible walked
Making decisions all the time leaves less time to reflect. At the time I'm knee-deep in budgets, so today I just walked . . . through classrooms. I see the faces of the kids to clear my head. It helps them to be visible to me. Greg Robinson
budgets decrease mean
This will mean a significant decrease of monies in the budget. Charles Leonard
budgets enterprise hope money people shoot throw
This was not a high-budget enterprise that I could see. Other people come to Hope to shoot commercials and such, and they throw money around right and left. Chuck Graham
budgets business few hope huge incredible movies needs opening shift stories types
There are so many screenwriters with incredible stories to tell, so I hope there will be some kind of shift in the business where very few types of movies are now made by the studios. There needs to be different budgets for different audiences; not everything having to be a huge opening weekend. Callie Khouri
budgets percent run sure
We're at 83 percent of our budget. I'm sure we'll run over. Jack Mitchell
budgets companies conscious corporate points popular price
Many companies are very conscious about budgets today. So the $35 to $100 price points are very popular with corporate accounts. John Petterson
choices fruit good-intentions
Good intentions are very mortal and perishable things. Like very mellow and choice fruit, they are difficult to keep. Charles Simmons
choices tests faces
The difficulties we face originate from one of three sources. Some are sent to us by the Lord to test our faith, others are the result of Satan's attacks, and still others are due to our own sinful choices. Charles Stanley
choices demand tough
Leadership demands that we make tough choices. Alan Autry
choices today tomorrow
When we make a choice today, we are deciding who we will be tomorrow. Aiden Wilson Tozer
choices remember clinton
Remember, this is a binary choice. It's going to be the approach that Donald Trump takes or the approach that Hillary Clinton takes, not some other approach. And the Clinton approach is just a completely unacceptable one, it's an unlawful one. Chris Christie
choices assistants sides
When he faced me again, he looked ashamed of himself. "I have gravely underestimated you, Darren," he said. "I will not do so again. I made a wiser choice than I realized when I chose you to serve as my assistant. I feel honoured to have you by my side. Darren Shan
choices doe ends
Everybody's got something. In the end, what choice does one really have but to understand that truth, to really take it in, and then shop for groceries, get a haircut, do one's work; get on with the business of one's life. That's the hope, anyway. David Rakoff
choices style singing
I enjoy all aspects of singing and I'm luckily given the choice to be part of different styles of music. Bryn Terfel
choices holiness mature
We don't accidentally drift into holiness; rather we mature gradually and purposefully, one choice at a time. C. J. Mahaney
commitment ifs
He did each single thing as if he did nothing else. Charles Dickens
commitment reflection giving
Each of us will eventually give away all our earthly possessions. How we choose to do so, however, is a reflection of our commitment to the kingdom of God. Charles Stanley
commitment giving acres
It is true that Mr. Lincoln signed the Emancipation Proclamation, after which there was a commitment to give 40 acres and a mule. That's where the argument, to this day, of reparations starts. We never got the 40 acres. We went all the way to Herbert Hoover, and we never got the 40 acres. We didn't get the mule. So we decided we'd ride this donkey as far as it would take us. Al Sharpton
commitment fargo local looking request san
We want them to have that local commitment to the community, and that's a big part of our request for proposals. We're not looking for Wells Fargo out of San Francisco. Tim Sanders
commitment pinch playing term
We want to try and pinch some of their ball. Nathan has a long term commitment to playing for Scotland. Frank Hadden
commitment thinking gas
I'm totally in favour of meeting our Paris commitments to reduce greenhouse gas emissions. But I don't think we should do that by making ourselves uncompetitive. Chris Alexander
commitment artist political
There is something about important stories that is not just the message, but also the way that message is conveyed, the arrangement of the words, the felicity of the language. So it's really a balance between your commitment, whether it's political or economic or whatever, and your craft as an artist. Chinua Achebe
commitment drug hiv
Treating HIV/AIDS is a lifelong commitment that demands strict adherence to drug protocols, consistent care, and a trusting relationship with health care providers. David Mixner
commitment political environmental
What's now urgently needed [to stop environmental disaster] is the international political commitment to take action to avoid dangerous climate change. David Miliband
customers focus
We want them to focus on customers and business, but they have to go to London. David Berkowitz
customers further peace proactive step
We want to take a much more proactive step and give our customers further peace of mind. Sanjay Gupta
customers employees excited lots potential received reception warm
We've already received such a warm reception from customers in Michigan. Just as we have customers who are excited about Ikea, we have lots of potential employees who are excited as well. Joseph Roth
customers employees full lost missed service
We're in full operation. We have not missed any service to our customers and our employees have not lost any time, Cindy Adams
customers tough
Where there's a tough call, we do what our customers would want us to do. Carly Fiorina
customers talk
When you talk to customers, you can tell that a lot of them are a lot more local. Alex Jones
customers
We want our customers to be able to tell the difference. Quincy Allen
customers people
When we have a corporation, we must know what the customer wants, what the customers needs. Also, the politician must know what the people want, what the people need. Joko Widodo
customers visiting
We are getting out and visiting customers more, and we are getting new customers calling, Greg Brown
depending fickle games moves time
We've addressed the ranking thing, and how fickle that is this time of year. Every weekend, two more games go by, and someone moves up or someone moves down depending on those games. So, the ranking doesn't matter. Red Berenson
depending evaluate options quantity received redeemed
We are going to see how many tokens we have once they are redeemed and will evaluate some options depending on the quantity that are received in our restaurants. Ron Evans
depending generate point
We are getting to the point where we are depending on Nate way too much. We need to generate more offense. Frank Rear
depending maine
Maine and us go back and forth, depending on the year. Peter Gregg
depending fixed money safety
Let's have a look at it, see what we can do with those (programs). Depending on the money situation, I think our sidewalks should be fixed ... I think we need to put safety first. Paul Niemann
depending focus less manure maximum primary rate slope
The primary focus is the maximum rate of manure-spreading, depending on the slope of the land. The steeper the land, the less manure you can apply. Kevin Connors
depending people
We need diesel. We'll find some. We have people depending on us and we are not going to let them down, Michael Barnett
depending either feminist spoke
I was put out there as a spokesperson for the new feminist revolution. It was very difficult because I was either too feminist or not feminist enough, depending on who you spoke to. Sarah McLachlan
depending information market quiet stock today
We don't have a lot of information today. I think today is probably a quiet day depending on what the stock market does. Bruce Alston
driving truck inns
Childbirth, as a strictly physical phenomenon, is comparable to driving a United Parcel truck through an inner tube. Dave Barry
driving force activism
Activism has always been the driving force for change. David Swanson
driving love soon together
We started driving around together as soon as we got our licenses. We love to drive. Nick Pisca
driving experience jump lost precious sudden turned upside
This sudden jump turned her driving experience upside down and her whole world upside down. She lost the most precious thing there was to her. Her intoxication had nothing to do with that. Elbert Hatchett
driving factors market nice reminder step
When you step back and put it all together, it's nice timing. It's a New Year's reminder of the geo-political factors that are driving the market higher. Mike Wittner
driving easy interstate
It's not supposed to be easy. It's not supposed to be driving down the interstate. Carl Edwards
driving girls help run
When you run with those girls every day, you can't help but get better and that is what is driving them. Tracy Harris
driving home safely
We want everyone to get home safely who may be impaired from driving for any reason. Bob Krueger
driving hurricane imagine looked loss months six
When we were first driving through the town, I was at a loss for words. It looked like the hurricane had just come through the day before we got there. I can not even imagine what it looked like six months ago. Ryanne Floyd
fuel help normal pursuing solutions
We are aggressively pursuing solutions that will help get fuel deliveries back to a more normal status, David Lemmon
fuel hard
Are you gonna fuel your faith or fuel your fear? I'm all about fueling my faith, especially when it's hard to do so. Carrie-Anne Moss
fuel increase massive seen
We have seen a massive increase in fuel prices. Martin George
fuel matter meaning producing research
We have said long before that the matter of research is not part of the negotiation, research has its own meaning and it has nothing to do with producing fuel industrially. Ali Larijani
fuel happy
We want more from the chancellor. We are not happy with the levy on fuel tax. Steve Williams
fuel talk
What they've got to do is talk about fuel efficiency. Daniel Gorrell
fuel head meeting objectives possible protecting start supply
We're getting a head start in meeting the president's objectives of protecting Americans from possible fuel supply disruptions this winter, Bill Richardson
fuel hoping instead offset passengers price raise ride
We're hoping to be able to offset the price of fuel ... by having more passengers ride ... instead of having to raise fares, Mike Rizzo
fuel understand
We know you're out there, ... We understand there's been fuel shortages. Bill White
habits rooted social toward
Some habits of ineffectiveness are rooted in our social conditioning toward quick-fix, short-term thinking. Stephen Covey
habits morals mostly social
Morals being mostly only social habits and circumstantial necessities. George Bernard Shaw
habits individual sleep therefore
Sleep habits are very individual and therefore shouldn't be overestimated. Elmar Basse
habits hoping might negativity remembered screw seem time
Then I remembered I was back on tour, and it was time to screw up. The old habits just don't seem to go away after the surgery. I was hoping all the old negativity might go away, but it's still there. Andrew Magee
habits interested investors time
It'll take time for old habits to break. But the more interactions with investors, the better. It's always better to get more investors interested in your company. Tom Taulli
hybrids though
Even though hybrids are a solution, they're not the solution. Carlos Ghosn
offering flames wind
Without the Spirit of God we can do nothing. We are as ships without wind or chariots without steeds. Like branches without sap, we are withered. Like coals without fire, we are useless. As an offering without the sacrificial flame, we are unaccepted. Charles Spurgeon
offering errors judging
Save me from the error of judging a church by its size, popularity or the amount of its yearly offerings. Aiden Wilson Tozer
offering giving offering-to-god
We ought not to be looking for a place to hide, but a place to give ourselves as an offering to God. Aiden Wilson Tozer
offering care return
By offering individuals ownership and control of their health care coverage, we return control to the patients; and that is exactly where it should be. Chris Chocola
offering media ideas
Being overseas at the time it all kind of happened was perfect because I had no idea that it was going to attract so much media attention and provoke these lovely people calling in and offering up their opinions and advice. Cathy Freeman
offer plane private response sea tigers
We are awaiting a response from the Tigers to an offer of a private sea plane for their use. Palitha Kohona
offering tickets
We started by offering tickets to evacuees in the Starkville motels. We thought we would give out about 200 or so. Larry Templeton
offering yankees guy
One of the best things about being a Yankee is that you have guys like Whitey Ford, Phil Rizzuto, Ron Guidry and Reggie Jackson wandering around the locker room offering you advice. Derek Jeter
offering perfect culture
No place is perfect, but I admire Oahu for its offering of the tropical and the urban, and then its Asian-inflected culture and cuisines. Chang-Rae Lee
realize work
We are getting better the more we work on this. We realize we have a lot of work going on out there. Bob Elek
realize taken
I think sometimes when things are taken away, then you don't realize how much fun it is to come out here and play this game. You can't play it forever, so I'm going to enjoy it. Tim Tebow
realized shows
When we were 15, my brother and I were getting really into Nirvana, Green Day, and The Beastie Boys. We started going to shows and realized we really wanted to be on stage. Joel Madden
realize
She's never been here and she doesn't realize that it will come down to her. She's about to puke. Denise Albrecht
realize
She makes me have fun. I don't even realize I'm learning, but I am, David Berry
realize
What the 'supposed 99 percent' don't realize is that they are better off if there are more fat cats, not less. Foster Friess
realize
When you are away from the game and busy with other areas, you realize that the world does not revolve around baseball. Cal Ripken, Jr.
realized
I was a young-un when I got my first million. Then I realized if I got one, I could get two. If I could get two, I could get ten. If I could get ten, I could get a hundred. Birdman
realize special
You don't realize it at first, but it really is special to be part of something like this. Ben Taylor
strategy habit achieve
Achieve success in any area of life by identifying the optimum strategies and repeating them until they become habits. Charles J. Givens
strategy takes
We're going to set our strategy and do what we think it takes to win. It won't be cheap. Lauren Cercone
strategy towards
One thing that is challenging Dell is its strategy towards higher-end products, Sam Bhavnani
strategy
My strategy is just to attack, attack and attack. Don Frye
strategy
And whereas [Donald] Trump let two or three hanging curveballs go by, [Mike] Pence will not, unless they have a strategy to let them go by. Donald Trump
strategy surround talk
Our strategy with someone like this is ... surround and talk. And we will talk for a long time. Bill Toohey
strategy
Part of our strategy is to be able to effectively encircle Yugoslavia for 360 degrees. Jamie Shea
strategy force company
Every new change forces all the companies in an industry to adapt their strategies to that change. Bill Gates
strategy structured suicide
We need to put a clear, structured suicide preventions strategy in place, Patricia Grogan