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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
andrew
Andrew had a gift for deepening the incision he began. Chris Cleave
andrew great
I have a great spouse, Andrew Cockburn, who's also a journalist. Leslie Cockburn
andrew blessing coach guys worry
What a blessing it is for a coach to have guys like Andrew and Horton. We don't have to worry about them when they're on the floor. Dana Addis
andrew hoping
We're hoping that Andrew will get through. He should get through. Vince Trombetti
andrew best conditions heat race ran robert run tough
There are tough conditions with the heat (90 degrees). Andrew ran the best race he has run this year. Robert ran the best race he has ever run. Ernie Chatman
andrew john knows proven susan themselves trust
I really trust Susan Stroman. I really think she knows what she's doing. I really trust Andrew Lippa and John August. I think they have proven themselves over and over again and know what to do, and they have the big picture in mind. Kate Baldwin
andrew talked
Andrew has talked about my character being the conscience of the film, the heart of the film. Jared Leto
andrew garfield wonderful
If I could play any superhero... my favorite superhero is Spider-Man. Andrew Garfield is wonderful at doing it to the point that I don't think I should play it. Taron Egerton
andrew bringing share sullivan thrilled
I am thrilled to share the news that Andrew Sullivan is bringing his trailblazing journalism to 'The Daily Beast.' Tina Brown
believe book writing
No men deserve the title of infidels so little as those to whom it has been usually applied; let any of those who renounce Christianity, write fairly down in a book all the absurdities that they believe instead of it, and they will find that it requires more faith to reject Christianity than to embrace it. Charles Caleb Colton
believe self denial
Forgiveness, that noblest of all self-denial, is a virtue which he alone who can practise in himself can willingly believe in another. Charles Caleb Colton
believe half literature
In religion as in politics it so happens that we have less charity for those who believe half our creed, than for those who deny the whole of it. Charles Caleb Colton
believe hallucinations scrooge
There's more of gravey than grave about you, whatever you are!" - Scrooge, referring to Marley's ghost which he believes is a hallucination from food poisoning Charles Dickens
believe remember cry
I verily believe that her not remembering and not minding in the least, made me cry again, inwardly - and that is the sharpest crying of all. Charles Dickens
believe soul done
Nothing that we do, is done in vain. I believe, with all my soul, that we shall see triumph. Charles Dickens
believe echoes sound
It is a silent, shady place, with a paved courtyard so full of echoes, that sometimes I am tempted to believe that faint responses to the noises of old times linger there yet, and that these ghosts of sound haunt my footsteps as I pace it up and down. Charles Dickens
believe adequate earth
And I am quite serious when I say that I do not believe there are, on the whole earth besides, so many intensified bores as in these United States. Charles Dickens
believe long people
It being a remarkable fact in theatrical history, but one long since established beyond dispute, that it is a hopeless endeavor to attract people to a theatre unless they can be first brought to believe that they will never get in. Charles Dickens
bothering-you bother ifs
If something is bothering you, keep it to yourself. David Strickland
both discovery driven east finds fossil mary since understand
With the discovery of Zinjanthropus at Olduvai Gorge in 1959, my grandmother Mary Leakey pioneered the research in East Africa with my grandfather Louis. Many more spectacular fossil finds have since been made, both in Africa and elsewhere, by many researchers driven to understand our past. Louise Leakey
both since
Wendy and I both wanted kids, but since we were pushing 40, the clock was ticking. Lisa Cholodenko
both feed suffice
I care not to debate which came first, Islamism or anti-Muslim bigotry; suffice to say that both feed into each other symbiotically. Maajid Nawaz
both direct guess project serious
There is a healthy fraternal rivalry, but nothing serious and we both have been looking for a project to do together. I guess he may direct me in a project some day. Mackenzie Astin
both country english federal issue kinds language laws learn official people practical side state
The other side said (there are) 799 federal and state laws mandating the use of English. ... We would say those kinds of laws are not at issue here. I think that English is the official language of this country in a practical sense already. And I think that most people who come here both learn English and want to learn English. Richard Cohen
both checks dressing great knows reason rooms sit sound together worse
The other reason Rufus and I are great together is that we're both really lazy. The rehearsing, the sound checks -- he's actually worse than I am, and that's something. To get us to do anything other than sit in our dressing rooms is a challenge. Who knows what will happen? Ben Folds
both potential
The potential is unbelievable with both those girls. Duncan Chase
both huge potential sales
The potential is huge for them both in sales and production. Tarun Das
capacities fallible good media people rare women
I think it's really rare to see women on television who are brilliant, selfish, vain, fallible - and I feel like I have all those capacities in myself, so it's good to see people in the media representing all of those things. Kerry Bishe
capacities physical serious
Let's say that (Sharon) has serious physical limitations, but in all other capacities he functions. There is no one better than him for the first place. Haim Ramon
capacities future people
Our young people - their capacities to think, understand, investigate, and innovate - are America's future. Robert Reich
capacities corruption good man mankind nature needs peace progress ten thousand until
It is good for man To try all changes, progress and corruption, powers, peace and anguish, not to go down the dinosaur's way Until all his capacities have been explored: and it is good for him To know that his needs and nature are no more changed, in fact, in ten thousand years than the beaks of eagles. Robinson Jeffers
capacities judge nor
Man's capacities have never been measured; nor are we to judge of what he can do by any precedent, so little has been tried. Henry David Thoreau
capacities people ready system trained various works
People are trained in various capacities and can be ready to go in 24 hours. The system works very well. Ed Waldapfel
capacities developing economy future science whatever
Science is really important for the long-term future of the country, I think it's important for the economy and I think it's important for developing the capacities of people, whatever they're going to do. George Ellis
capacities leader life staff
He's our leader and obviously, you want your leader around. But he's a leader in other capacities of his life and that's why he is where he is today. We do everything as a staff and we're all on the same page. Wade Klippenstein
capacities country government officials respect witch
It's a witch hunt, it's not in our traditions. We respect the capacities to have professional officials working for their country when the Government changes. Stephane Dion
christmas children sometimes
For it is good to be children sometimes, and never better than at Christmas, when its mighty Founder was a child Himself. Charles Dickens
christmas men alive
And it was always said of him, that he knew how to keep Christmas well, if any man alive possessed the knowledge. May that be truly said of us, and all of us! And so, as Tiny Tim observed, God bless Us, Every One! Charles Dickens
christmas honesty hands
Christmas was close at hand, in all his bluff and hearty honesty; it was the season of hospitality, merriment, and open-heartedness; the old year was preparing, like an ancient philosopher, to call his friends around him, and amidst the sound of feasting and revelry to pass gently and calmly away. Charles Dickens
christmas new-year years
A merry Christmas to everybody! A happy New Year to the world! Charles Dickens
christmas heart men
But I am sure that I have always thought of Christmas time, when it has come round...as a good time; a kind, forgiving, charitable, pleasant time; the only time I know of, in the long calendar of the year, when men and women seem by one consent to open their shut-up hearts freely. Charles Dickens
christian courage firsts
A Christian builds his fortitude on a better foundation than stoicism; he is pleased with every thing that happens, because he knows it could not happen unless it first pleased God, and that which pleases Him must be best. Charles Caleb Colton
christian white house
My lowest days as a Christian have been more fulfilling and rewarding than all the days of glory in the White House. Charles Caleb Colton
christian hate envy
The hate which we all bear with the most Christian patience is the hate of those who envy us. Charles Caleb Colton
christian mind sorrow
Some well-meaning Christians tremble for their salvation, because they have never gone through that valley of tears and of sorrow, which they have been taught to consider as an ordeal that must be passed through before they can arrive at regeneration. To satisfy such minds, it may be observed, that the slightest sorrow for sin is sufficient, if it produce amendment, and that the greatest is insufficient, if it do not. Charles Caleb Colton
identified performing
We are getting better with every match, and performing better with every match. We have identified some things that we can do better, and we know what we can do to improve. Craig Manning
identified
We have identified the individuals, and they will be getting a bill. Ben Wolcott
identified stage various
We have identified some bowlers, but at this stage we haven't been able to use them for various reasons. Greg Chappell
identified men personnel service woman
We have identified 30 service personnel 29 men and one woman who could use our services. Helen Arnold
identified profoundly whom
The fictional character with whom I most profoundly identified was Yossarian in Catch-22. Always did, still do. Neil Cross
identified meant people played sticking stop street
Mr. Big has been sticking to me, and that makes me uncomfortable. I know it's meant well when people stop me in the street and say, 'Hey, Mr. Big!' But I don't ever want to be identified by any part I've played once it's over. Chris Noth
identified incident involving largely officer program training
Morano identified the need for this training program in December, largely in part because of the incident involving officer McDermott and officer Diaz. Lisa Holden
identified means saw scary strongly takes
I think what I reacted to so strongly when I first saw 'Pinocchio' was that I identified with the character so strongly. The movie takes you on a whole journey, a rollercoaster of emotions, and that sometimes means some very scary places. But in the end, it comes out okay. Chris Buck
identified looked swedish
I always identified myself as non-Swedish. I was never discriminated against, because I looked Swedish and speak without an accent. But I had an outsider's perspective. Joel Kinnaman
lasts remember there-is-hope
Remember, to the last, that while there is life there is hope. Charles Dickens
lasts fool firsts
Ridicule is the first and last argument of a fool. Charles Simmons
lasts dubbing spokes
I have just returned from the dubbing studio where I spoke into a microphone as Severus Snape for absolutely the last time. Alan Rickman
last nine won
We've won nine of the last 11, so I like our chances. Eric DiBiase
last people ready year
We want to show that we're no joke. People thought last year was a fluke. We can make improvements from last year. We're ready to see what's out there. Andrew Palmer
lasts eloquent last-time
We looked at each other for the last time; nothing is as eloquent as nothing. David Mitchell
lasts records haircuts
You're only as good as your last record. David Sanborn
lasts female worship
The last western society to worship female powers was Minoan Crete. And significantly, that fell and did not rise again. Camille Paglia
lasts needs kind
I need some kind of... like... last minute, poorly-set-up deus ex machina!! Bryan Lee O'Malley
leadership hope encouragement
Times of great calamity and confusion have been productive for the greatest minds. The purest ore is produced from the hottest furnace. The brightest thunder-bolt is elicited from the darkest storm. Charles Caleb Colton
leadership steps arrogant
God will never direct us to be prideful, arrogant and unforgiving, immoral or slothful or full of fear. We step into these things because we are insensitive to the leadership of the Holy Spirit within us. Charles Stanley
leadership decision benefits
Leadership requires the courage to make decisions that will benefit the next generation. Alan Autry
leadership sports winning
So what if I never win my fifth gold medal; It's only one end of the string. It's competing that matters. It's proving that there is a place for guys like me in sports. It's a persona challenge to extend myself. Al Oerter
leadership basketball sports
Winning is overrated. The only time it is really important is in surgery and war. Al McGuire
leadership sports zero
I believe in a business boarding up early. If you make a mistake, you put the boards in the window of the store and say, "Hey, I made a mistake." Let me take two shots in the arm and a punch on the nose and let me get on to the next thing. I don't believe in worrying over failures. I worry about successes. This is opposite from most people. Most people zero in on their failures. I try to keep all my attention on a pyramid type philosophy rather than the averaging-down philosophy. Al McGuire
leadership voice ideals
The ideal leader is one who hears the voice of God, and beckons on as the voice calls him and them. Aiden Wilson Tozer
leadership work reality
I would rather die than be in the United States Senate. I would be bored to death. Could you imagine me, banging around that chamber with 99 other people, asking for a motion on the amendment in the subcommittee? Forget it...You'd watch me just walk out and walk right into the Potomac River and drown. That would be it. Chris Christie
leadership health eye
The President's biggest problem right now is he's gotta tell the truth. And we've seen this in New Jersey. I've told lots of hard truths in New Jersey that people didn't necessarily agree with, but they give you credit for looking them in the eye and telling them the truth. Chris Christie
players position table
The position that's on the table by the players just isn't acceptable. Jerry Jones
players
We have so many players from New Orleans. It's always in the back of our minds. Justin Vincent
players playing starting
We're starting to do some things but we can't let up. It's a do-or-die situation, so the players are playing with a sense of urgency. Dwight Freeman
players
We're just not comfortable with our go-to players in the stretch. Mike Carey
players
We're getting better. We have players who are pretty focused. Pat Gillick
players quality signed
We know we have signed quality players - but they will need time. Thomas Doll
players
Makes a big difference. Players always make the difference. Jim Leyland
players stop takes
L.T. is fast. It takes 11 players to stop him. If 11 players are on the same page, then it's cool. But it's going to be very hard. Zeke Moreno
players skilled time
We won't be one-dimensional on offense, ... We have linemen who can give our skilled players time to make the plays. Tom Bailey
potential quickly respond
The potential is there for transmissible outbreaks and we want to be able to respond to these as quickly as possible, but also to have up-to-date information, Tom Clark
potential
The potential for these waystations is just terrific. Chip Taylor
potential unlimited wise
We feel that the potential is unlimited for Wise County. Bobby Collins
potential
She has the potential to be one of the greatest, if not the greatest. Bill Davoren
potential scratched surface
We have just scratched the surface of our potential business. Robert Turner
potential race
This race has the potential to be around for a while. Right out of the chute, it's prestigious. James Raia
potential realize starting
She's starting to realize the potential she has. Aubrey Edgmon
potential prove starter whenever
She wanted to be a varsity starter very badly. You could see she had the potential, but whenever she got on the floor, she wanted to prove too much to me. Jackie Parsley
potential reach showing takes until
She's showing a lot of potential. It usually takes until they're about 3 years old for them to reach their potential, but she's there. Jesse Miltier
refined stalinism
Perestroika is nothing more than refined Stalinism. Dan Quayle
refined structured
It was so beautiful. Such extraordinary colors, classical, and refined and very structured as well. A superb collection. Catherine Deneuve
refined defined
Don't be defined by your failures, be refined by them. Max Lucado
refined knows seems
It seems unpleasantly refined to put things off till someone knows. William Empson
structure sitcom
I like the sitcom, as a structure. Dave Foley
structure figures multiple
They say that structure is freedom, and in a sense it is. When you're dealing with multiple constraints, you have to figure out what you can get out of that. Demetri Martin
structured time
We still have old time play time at recess, but we have structured play as well. Jerry Green
structure
Questions structure and, so, to some extent predetermine answers. A. R. Ammons
structure skeptical agree
I agree with Chomsky in almost nothing. When it comes to innate structures and so on, I'm very skeptical Clifford Geertz
structured time
If we're going to have recovery, we're going to have to have structured government. Time is of the essence, Kathleen Blanco
structure accord happens
Our psyche is set up in accord with the structure of the universe, and what happens in the macrocosm likewise happens in the infinitesimal and most subjective reaches of the psyche Carl Jung
structure
We wanted to make the motel better, but renovating the old structure would just have been a humongous problem. Laura Puchowicz
structures
A lot of these structures are going to come down. David Schwartz