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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
countries demand emissions energy expand gas greenhouse growth help improve incredible production reduce renewable seeing seek wind
We are seeing an incredible growth in demand for wind turbines as more countries seek to expand their renewable energy production to help reduce their greenhouse gas emissions and improve their energy security. Robert Gleitz
countries europe final genuine gone help meant needed poor round service talks throes trade
We are potentially in the final throes of this round of talks at the World Trade Organization, which was meant to help poor countries but has gone way off track. What is needed from Europe now is not self-interest and intransigence but genuine concessions that will put trade at the service of development. Jeremy Hobbs
countries italy name
There are countries where the organizers don't know what they're doing or what's going on - but I wouldn't name Italy and Spain! Robert Smith
countries move
There are countries that want only gold. We may move to that at some point. Chris Rudge
countries looked others simply
There are countries that have collaborated actively, and there are others who have tolerated. Others have simply looked the other way. Dick Marty
countries external fit free function grow history influence interested manner ways
There are countries like Paraguay and others, their neighboring countries, they're all interested in being able to grow and function in a manner that's free of external influence and to do things in ways that fit their history and their circumstance, Donald Rumsfeld
countries heard people
There are countries I've never heard of that have like 20 people playing, Paul Nelson
countries exchanges hold question ready stand
We stand ready to hold exchanges with other countries on the question of the exchange rate. Yang Jiechi
countries denied ground kiss people seeing
When we got back to the U.S., I wanted to kiss the ground after seeing what people in other countries are denied or don't have. Sugar Ray Leonard
dealing might serving stop
We want the pedophiles to give it a thought, that they might be dealing with the police, ... And if we can stop them ... then we are serving our purpose. Robert Randall
deal dime increase nickel offer recognizes table three wage
We want them to get an offer to the table that they can live with. We want a deal that is more than just a nickel and a dime an hour. We want a deal that recognizes that they went without a wage increase for three years. Dave Minshall
deal might ready supposed systems understand whatever
We want them to be ready for whatever they might have to deal with on that first flight; to understand what to do if some of the systems don't do what they're supposed to. Jim Smith
dealing hierarchy might military properly
We want to set this up properly because we are dealing with a military hierarchy and I might set it up wrongly. Michael Defensor
deal opportunity positives sanctions ten tournament understanding
The positives are closure. We're going into the Big Ten tournament and we want our student-athletes to have the opportunity to participate in this tournament understanding there won't be any sanctions they have to deal with. ... They can play without that stress. Gene Smith
deal egyptian palate pleasures strangle whom
The pleasures of the palate deal with us like the Egyptian thieves, who strangle those whom they embrace. Lucius Annaeus Seneca
deal earn employees exemplary great hard hard-work honor proud represents salute share team work
We are proud to earn this award. It represents a great deal of hard work for us, for our suppliers and for their suppliers. We salute our team of exemplary employees and suppliers, and share this honor with them. Steve Perkins
deal later super
We started the deal and here they are 30-years later in the Super Bowl. Rolly Woolsey
deals people valuable
There are some deals to be made right now. Some people don't want to rebuild. And they don't want the headaches. But it's not as valuable as it will be in the future. Craig Brown
develop enormous potential
The potential is enormous but it's up to us to really develop that leisure-oriented market. Dave Foley
developed increased last prepared profits strongly
We are prepared for an IPO. Bertelsmann has developed strongly in the last years and increased its profits considerably. Gunter Thielen
develop mean
We've always been able to score. We've got to more defensive-minded. We've got to develop that mean streak. Brian Clodi
develop forward looking national practical pricing problems road solutions support
We are looking forward to working with these authorities to develop practical solutions to congestion problems and support the development of a national road pricing scheme, Alistair Darling
developing draft encouraged five forward further inside list looking national picks prospect structure top
We are looking forward to further developing the list structure through the AFL National Draft and are encouraged by the prospect of having five picks inside the top 22. Chris Pelchen
develop technology
We still use 1940s technology to develop influenza vaccines. Greg Poland
developing neurons produced record signals technique
We started all this research way back in the early 1990s, developing a technique that allows us to record the electrical signals produced by neurons simultaneously. Miguel Nicolelis
developing experts head state
Where there are two Phd's in a developing country, one is head of state and the other is in exile. Lord Samuel
developed further programs public
Where it is necessary, programs will be further developed with public discussion, Gerhard Schroeder
greatness men mind
Great men, like comets, are eccentric in their courses, and formed to do extensive good by modes unintelligible to vulgar minds. Charles Caleb Colton
greatness deserving-it mind
Great minds had rather deserve contemporaneous applause without obtaining it, than obtain without deserving it. If it follow them it is well, but they will not deviate to follow it. Charles Caleb Colton
greatness men
In life we shall find many men that are great, and some that are good, but very few men that are both great and good. Charles Caleb Colton
greatness men too-much
Speaking generally, no man appears great to his contemporaries, for the same reason that no man is great to his servants--both know too much of him. Charles Caleb Colton
great-expectations secret tears
The secret was such an old one now, had so grown into me and become a part of myself, that I could not tear it away. Charles Dickens
great-expectations strange melancholy
So new to him," she muttered, "so old to me; so strange to him, so familiar to me; so melancholy to both of us!... Charles Dickens
great-expectations may done
But, in this separation I associate you only with the good and I will faithfully hold you to that always, for you have done far more good than harm, let me feel now what sharp distress I may. Charles Dickens
great-expectations may let-me
Let me feel now what sharp distress I may. Charles Dickens
greatness excellence littles
True greatness consists in being great in little things. Charles Simmons
homeland meet threats undermines
An overstretched military undermines homeland security and our ability to meet threats around the world. Ellen Tauscher
homeland-security needed available
Working very closely with the Department of Homeland Security to match up what is available with what is needed. Condoleezza Rice
homeland regime survivors tolerate
We, as the homeland of the survivors of the Holocaust, will not tolerate that regime in Austria. Haim Ramon
homeland security
Regrettably, you need homeland security, and I think you are going to need it if not forever, for the foreseeable future, Arlen Specter
homeland military realized security value
We are disappointed ... the military value and homeland security value of Ellington wasn't realized by the commission. John Cook
homeland security test
As a test of the homeland security system, this was a failure, ... woefully inadequate. Newt Gingrich
homeland overseas security sent terrorists worry
The terrorists are still here. I really do worry about our troops' being sent overseas and depleting our homeland security. Thomas Murphy
homeland
We see our homeland more clearly when we are away from it than when we are in it. Nawal El Saadawi
homeland hometown secure
The homeland is secure when the hometown is secure. Tom Ridge
including insurance performed positive quite surprise
The positive surprise is insurance in Europe, which has performed quite well, including in the Netherlands. Carlo Ponfoort
including noticing won
When you've won an Oscar, everyone is really scrutinizing what you do, including every movie you do. So if it's bad, they're noticing it more. Robert Thompson
including surfing
Surfing the Internet every day has become a habit for many leaders and officials, including myself. Li Yuanchao
including organized statements top understood watching
Watching how simultaneously statements are made, including at the top level, it can be understood that this is an organized campaign. Vladimir Litvin
including playing situation
We've never encountered this situation before. Everyone, including the U.S., is playing this by ear. Yossi Alpher
including life
I should have been deliriously happy. I had my dream come true. I'm a best-selling author. So why is everything in my life, including my writing, going bad? Tawni O'Dell
including marxism open scientific
For us, Marxism is always open because there are always new xperiences, there are always new facts, including facts about the past, which have to be incorporated in the corpus of scientific socialism. Ernest Mandel
including pay sign
With Typekit, you sign on, you pay a single subscription fee. We're including that as part of Creative Cloud. Kevin Lynch
including local small victims women workers
Most of the victims were local labourers, including women workers with infants and small children. Anil Kumar
iran revolution problem
We did not treat the Americans badly. They left Iran in a relaxed mood. The embassy was active here after the revolution. We didn't have any problem with them. They started it. Akbar Hashemi Rafsanjani
iran outcomes tough
Passing a tough resolution or threatening Iran will not bring about the desired outcome. Akbar Hashemi Rafsanjani
iranians russia serious whether
We want the Iranians to negotiate, whether it's with the EU-3 or Russia or any other country, on a serious basis. Nicholas Burns
iran empowering unrest
When we empower Iran, then get ready for more unrest and more murder and more violence in the Middle East. Chris Christie
iranians position taken
The position that has been taken by the Iranians is so extreme, John Reid
iran prices resolved unless until
Until and unless the stalemate with Iran is resolved one way or the other, I think we're going to see prices higher. Fadel Gheit
iran usa two
The Obama presidency has two great missions: fixing the economy, and preventing Iran from gaining nuclear weapons. Benjamin Netanyahu
iran september-11 united-states
After September 11, when the United States took action to overthrow the Taliban, our interests and Iran's aligned, and we were able to coordinate quietly but effectively. Earl Blumenauer
iran europe games
While the United States has largely been missing in action from the diplomatic game, the European Union and Iran have been making progress at developing a formula that would lead to the suspension of Iran's nuclear enrichment program and the start of serious negotiations. Earl Blumenauer
korea cuba lasts
After the Soviet collapse, Marxism is a relic, a pathetic anachronism reduced to its last redoubts: North Korea, Cuba, and the English departments of the more expensive American universities. Charles Krauthammer
korea want proud
Iranians are very proud and don't want to become a pariah state like North Korea. Edward Luck
korea america car
North Korea has the same ability to launch a nuclear strike against America as I do. It's like walking through a parking lot and getting barked at by a chihuahua locked in a car. Bill Maher
korea president democracy
The president had a press conference about this this week and he said that the U.S. has no plans to attack North Korea. And then he added, 'Like having no plan ever stopped me before.'. He has something even more deadly in store for them - we're going to bring them democracy. Bill Maher
korea government people
The greatest threat to the security of the people of North Korea comes from the government of North Korea. Ari Fleischer
korea favors rewards
I would not suggest the U.S. should sit down with the North Koreans bilaterally immediately after they've fired missiles - because the appearance is that you reward bad behavior. But if North Korea behaves for some period of time, I would pretty much favor direct talks. Richard Armitage
korea censorship
There's hardly any governmental censorship in Korea. Bong Joon-ho
korea support needs
If South Korea is going to survive, and keep the peace on the peninsula, its citizens need to start conveying support for their state. Brian Reynolds Myers
korea people republic
People tend to overlook the fact that North Korea's economy collapsed at about the same time as South Koreans lost faith in their own state. The late 1980s and early 1990s were a time when South Koreans were questioning the very legitimacy of their republic. Brian Reynolds Myers
mass-extinction exception-to-the-rule survival
Extinction is the rule. Survival is the exception. Carl Sagan
mass-destruction wmd goal
We should be hell bent on getting those weapons of mass destruction, hell bent on having a credible approach to them, but we should try to do it in a way which keeps the world together and that achieves our goal which is removing the... defanging Saddam.. Carl Levin
massive preparing relief
We are preparing for a massive relief operation, Ruud Lubbers
mass
You can't create a mass market if you don't have a common standard. Henry Samueli
mass-destruction iraq long
The liberation of Iraq was part of a broader effort to seriously confront the greatest threat to world security: rogue states capable of obtaining long range weapons of mass destruction. Armstrong Williams
mass-destruction weapons destruction
Those weapons of mass destruction have got to be somewhere... Nope, no weapons over there... Maybe under here. George W. Bush
mass-destruction weapons destruction
Fear is a weapon of mass destruction. Dennis Kucinich
mass-destruction tyrants iraq
There is no doubt that Saddam Hussein's regime is a serious danger, that he is a tyrant, and that his pursuit of lethal weapons of mass destruction cannot be tolerated. He must be disarmed. Edward Kennedy
mass-destruction years iraq
We have known for many years that Saddam Hussein is seeking and developing weapons of mass destruction. Edward Kennedy
money giving grace
Riches may enable us to confer favors, but to confer them with propriety and grace requires a something that riches cannot give. Charles Caleb Colton
money evil gains
To cure us of our immoderate love of gain, we should seriously consider how many goods there are that money will not purchase, and these the best; and how many evils there are that money will not remedy, and these the worst. Charles Caleb Colton
money greatest-wealth want
Wealth after all is a relative thing since he that has little and wants less is richer than he that has much and wants more. Charles Caleb Colton
money battle half
economy is half the battle of life; it is notso hard to earn money as to spend it well. Charles Spurgeon
money people saving
So many people of wealth understand much more about making and saving money than about using and enjoying it. They fail to live because they are always preparing to live. Alan Watts
money thinking people
The reason we have poverty is that we have no imagination. There are a great many people accumulating what they think is vast wealth, but it's only money... they don't know how to enjoy it, because they have no imagination. Alan Watts
money children clothes
And money is not something to go mad about ... Money is for food and clothes and comfort, and a visit to the pictures. Money is to make happy the lives of children. Alan Paton
money law issues
As long as we issue fiat currency, I see no alternative to a legal tender law. Alan Greenspan
money gold wealth
Deficit spending is simply a scheme for the confiscation of wealth. Alan Greenspan
near nowhere pleased
We are pleased with our progress, but we are nowhere near where we want to be yet. Bob Stull
near nowhere ought
We've accomplished what we've wanted to accomplish, record-wise. But we're nowhere near where we should be or where we ought to be. Rick Pitino
near puncture
We started as if we were on a qualifying lap, got a puncture near the end but we got it home, Eddie Jordan
near stage
We are getting near to the stage where hardball will be played. Seamus Mallon
near obviously
We're getting near the end of the process, but obviously it is not over yet, Richard Peddie
near standing trash
Yes, he was standing near the trash can. James Williams
near quickly strange time
I write in a very strange way. Things are very fragmentary for a very long time, and then they come together very quickly near the end of the process. Todd Rundgren
near park popular problem seems water work
Sheldon Park is a little too popular with the geese. KES isn't near water so we don't have the same problem and it seems to work out better for everyone. Mike Irwin
nearest number people water
We have a number of people we just dispatched all day long to go to the nearest place where the water is problematic. George Hecht
north-carolina carolina feels
North Carolina was where you could have Thanksgiving and feel like it was Thanksgiving. David H. Murdock
northern school
To our knowledge, this is the first (designated) film school in Northern Colorado. Brian Sky
north
In California, there is a strong tension between north and south. Thomas Mars
north ordered personally reagan truth visa
If I could go, I would tell the truth to the North American people. President Reagan personally ordered my visa to be denied. Tomas Borge
northeast percent traffic
Sixty-five percent of our traffic comes in the northeast corner. Rick LeLacheur
north
When I was 16, I used to hang out at the Nambucca pub in North London and see The Libertines play live. Jamie Campbell Bower
north require sustained work
We use this work every day in North Carolina. All of these investments are not one-time. They require a sustained commitment. Leah Devlin
north run
What you want to do is run the carpetbaggers up north empty-handed. Howard Schnellenberger
northern
Northern Iraq has become, economically, a natural extension of Turkey. Ali Babacan
possibly respond state
We're going to need everything that we can possibly muster, not only in this state and in the region, but the nation, to respond to this event. Michael Brown
possibly saints state
LSU did everything it possibly could to accommodate the state of Louisiana, the Saints and the NFL. Bernard Boudreaux
possibly sopranos subtext women
Personally, I don't think we could do such a show if we didn't get along. The subtext of all this is that we're women in a show so we can't possibly get along. It's not like they write about The Sopranos like that. Kristin Davis
possibly
I want to do everything I can possibly do to step outside the box. Lilly Singh
possibly
I used to comfort myself when I became an actor that it was a useful job, entertaining people. And it was important to do it as well as you possibly can. Ian Mckellen
possibly radically work
Sookie is about as radically different from me and a lot of the work I've previously done as you could possibly come up with. Anna Paquin
possibly
My first thought was that she could have possibly been dead. Howard Clark
possibly realistic release releasing seriously soon spring thinking worried
No one is seriously thinking a spring release is realistic any more. If I were Sony, I wouldn't be that worried about releasing as soon as I possibly could. Hiroshi Kamide
possibly protect
We did everything we possibly could to protect her. Pat Camden
reach struggle stuff
When you struggle to reach for something you don't know, that's where the most interesting stuff is. Herbie Hancock
reach seek
When they want to seek our vote, they know where to reach us, Abner Louima
reaches
You always dream of being part of a show that reaches and thrills an audience. Nikolaj Coster-Waldau
reach time
We are going to take the appropriate time to reach our long-term aspirations. Phil Anderton
reaches technology transcends
Wherever technology reaches its real fulfillment, it transcends into architecture. Ludwig Mies van der Rohe
reaches whose
My heart reaches out to those whose loved ones were lost on MH17. Najib Razak
reached
I want to be able to say on my deathbed that I reached a few people. That would be very nice, just to be able to say that. Evelyn Glennie
reaching vision
Keep your feet on the ground and keep reaching for the stars. Casey Kasem
reach
Of course, it is me being able to reach my goal, Evander Holyfield
several
I'm a McDonald's girl - several times a week. Usually the two-cheeseburger combo meal. Nikki Cox
several
What I always want is to have several little 'aha' moments where your brain is very happy. Scott Kim
several students
Several students have called and said, 'I have a video, do you want it?' Bill Hall
several tony
We didn't do anything spectacular on offense. But Tony Porto bailed us out several times. Jim Sweeney
several
I've several times had jobs that I thought were going to be my big break, and it didn't pan out. Toks Olagundoye
several time
And we also read Newsweek, Time and several newspapers. Hanoi Hannah
several
We're going to be there for several days. Ruth Winstrom
several talk witnesses
We were able to talk to several witnesses at the playground. James Gill
several
We don't know when he's going to be back. He'll be out for several weeks. That's a big deal. Greg Strobel
spending enjoy ifs
What would you like to do if money were no object? How would you really enjoy spending your life? Alan Watts
spending born deficit-spending
I understand deficit spending. I was born in deficit spending. Al Sharpton
spending combination increase
If we increase spending, we have got to raise taxes or any combination. Bobby Scott
spending-time spending feels
Spending time outdoors makes you feel great. Elizabeth Hurley
spending
I was not interested in spending 10 years in the culture wars. Leon Wieseltier
spending
You cannot keep out of trouble by spending more than you earn. William J. H. Boetcker
spending federal-spending
Federal spending is atrocious. Jason Chaffetz
spending
I don't think anyone's pushing for spending limits in the campaign. Craig Benson
spending
know that there has to be a spending limit. Arnold Schwarzenegger
time son boys
A boy's story is the best that is ever told. Charles Dickens
time fool calendars
Tomorrow! It is a period nowhere to be found in all the registers of time, unless, perchance, in the fool's calendar. Charles Caleb Colton
time all-things
Time is the measurer of all things, but is itself immeasurable, and the grand discloser of all things, but is itself undisclosed. Charles Caleb Colton
time retreat tides
Time ... advances like the slowest tide, but retreats like the swiftest torrent. Charles Caleb Colton
time two black
Time,- that black and narrow isthmus between two eternities. Charles Caleb Colton
time looks one-thing
To look back to antiquity is one thing, to go back to it is another. Charles Caleb Colton
time world overcoming
Time is the most subtle yet the most insatiable of depredators, and by appearing to take nothing is permitted to take all; nor can it be satisfied until it has stolen the world from us, and us from the world. It constantly flies, yet overcomes all things by flight; and although it is the present ally, it will be the future conqueror of death. Charles Caleb Colton
time journey men
Much may be done in those little shreds and patches of time which every day produces, and which most men throw away. Charles Caleb Colton
time opportunity enemy
Time, the cradle of hope.... Wisdom walks before it, opportunity with it, and repentance behind it: he that has made it his friend will have little to fear from his enemies, but he that has made it his enemy will have little to hope from his friends. Charles Caleb Colton
types
We do need different types of propulsion to get to Mars. I wrote one of the first Ph.D. theses on that in the 1960s. Edgar Mitchell
types
We all know the types who listen to Pete Seeger songs; even Pete admits they aren't interesting. P. J. O'Rourke
types
To be honest, I enjoy all different types of films and experiences. Abbie Cornish
types
I've been charged with misappropriation of funds or misuse of two types of funds. Chen Shui-bian
types
There are two different types of leader. A person can either be like a thermometer or a thermostat. A thermometer will tell you what the temperature is. A thermostat will not only tell you what the temperature is, but it'll move you to the temperature you need to get to. Kevin McCarthy
types
There's always going to be short-term fluctuations. But we think they're going to do well in all types of markets. Dan Ahrens
types vicious
I just don't think I've had the desire yet to write a vicious animal - like a dog-gone-bad or anything - where I do feel that I need a balance of all types of humans. Sara Gruen
weapons tools negotiating
Food is a tool. It is a weapon in the U.S. negotiating kit Earl Butz
weapons sometimes wounds
Words are like weapons; they wound sometimes. Cher
weapons changing-environment dinosaurs
The dinosaurs disappeared because they could not adapt to their changing environment. We shall disappear if we cannot adapt to an environment that now contains spaceships, computers — and thermonuclear weapons. Arthur C. Clarke
weapons
Women can stand a beating except when it is with their own weapons. Samuel Butler
weapons human-nature realizing
When the gunman realizes that nobody else is armed, he will lay down his weapons and turn himself in ... that's just human nature. Dianne Feinstein
weapons needs construction
We need to be weapons of mass construction, weapons of mass love. It's not enough just to change the system. We need to change ourselves. Walter Benjamin
weapons mein-kampf willpower
If freedom is short of weapons, we must compensate with willpower. Adolf Hitler
weapons sophisticated defeated
The Afghans did not have sophisticated weapons like the Soviets did, but with their faith they defeated a superpower. Abu Bakar Bashir
weapons junk defeated
The national security state has many unfair and cruel weapons in its arsenal, but that of junk science is one which can be fought and perhaps defeated. Aldrich Ames