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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
economy currency biosphere
Other things, like capitalism, free enterprise, the economy, currency, the market, are not forces of nature, we invented them. They are not immutable and we can change them. David Suzuki
economy mistaken perception train
The perception that the U.S. economy is a runaway freight train is mistaken -- things are slowing. Matthew Smith
economy extent fact issues ongoing pace recovery slowing strength week whether
The ongoing issues are the strength of the economy and whether or not the pace of the recovery is in fact slowing down. One of the important things this week will be to see the extent of the damage. John Davidson
economy growing region resilient seeing seems
We are seeing a very resilient economy and one that seems to be growing in every part of the world. Just about every region is growing and it's very encouraging. Sidney Taurel
economy fears finds full hard
There are some fears that the post-war U.S. economy still finds it hard to go back into full gear. Shahab Jalinoos
economy global wine
We're in a global wine economy now. If you're out of grapes, you're out of grapes. George Rose
economy fact fiscal growing monetary stimulus
When you think of all the fiscal and monetary stimulus we've had, we should have the economy growing at 5 or 6 percent. The fact that we're not is the story. David Rosenberg
economy government human science useful
The government will see that human spaceflight is useful - for science and the economy - and inspirational. Helen Sharman
economy few growing industry innovation particular past rapid seen technology within
We have seen China's economy growing at 8-9% over the past few years and in particular within the telecom industry there has been rapid developments in technology and innovation enhancements, Patricia Russo
fill
Where there is a need we will fill it. Gayle Falkenthal
filled lives needs quite
We go through our lives in a continual dance of being filled with something that needs an answer, and then going out and finding that answer... only to find out that our answer wasn't quite the answer. Guy Finley
filled-in acting want
I feel like a bit of a phony sometimes - I started acting because I didn’t know what else to do. I filled in all these university application forms and honestly didn’t want to do any of the courses. Aidan Turner
filled guys people
We always have a lot of new guys come out for the team, but the new guys have a lot of potential. Before, we just had people who filled the spots. Gary Dunn
fill gaps promote today understanding
We want to promote understanding and fill in the gaps today or tomorrow. Yoshinori Ohno
fill looking secured
We have secured one cargo in January, two in February. We are looking to fill one of our two slots in March. That's the arrangement so far. David Nicholas
filled include past people poor
We have to get past the standardized image. It didn't include any of the poor people - any of those neighborhoods that we only know now because they're filled with water. Mark Wigley
filling item quite
When you see an item like that, you have to have it because it is filling a void. It is something you didn't know you wanted. It can be quite emotional. Natalie Massenet
filled-out may facts
You may have read that I went to M.I.T. In 1982 I filled out a Who's Who survey with joking responses, and they never bothered to check the facts. Chevy Chase
five member
We are a five member board...we had no discussion, David Holden
five pennant race runs
We're in a pennant race here, ... We're doing everything we can to win. And five runs in two innings, we can't do that. Ron Gardenhire
five hot pandemic spotlight weeks zero
We started from zero five weeks ago to all this hot, hot spotlight on pandemic flu, but we're not going to be ready. Irwin Redlener
five helping lost match minutes start talk
We started five minutes after (Kline) lost. It's something you reel in right then. You start helping him refocus. You don't talk too much about the match he just lost but about what we're going to do in the future. You have to be there to help him. David Grant
five games losing loss months spent
We spent five months losing series. That's what has us five games back - not the loss tonight. Felipe Alou
five good hopefully level top
I never had goals to be in the top 10 or top five in the world. I just try to find the borders, find what level I can reach. I have a good team around me, so hopefully it's going to get even better. Lukas Rosol
five hundred sea travel undertaken
A journey by Sea and Land, Five Hundred Miles, is not undertaken without money. Lewis Hallam
five players regardless talent
We're not going to make excuses. You put five players on the court, regardless of who's hurt. Obviously, we have enough talent to win. Erick Dampier
five four helps softball sponsor summer teams
We also sponsor four or five softball teams which helps us during the summer months. Terry Stralow
growing-up women thinking
... the woman who grows up with the idea that she is simply to be an amiable animal, to be caressed and coaxed, is invariably a bitterly disappointed woman. A game of chess will cure such a conceit forever. The woman that knows the most, thinks the most, feels the most, is the most. Intellectual affection is the only lasting love. Love that has a game of chess in it can checkmate any man and solve the problem of life. Charles Dickens
growing-up people needs
Many people never grow up. They stay all their lives with a passionate need for external authority and guidance, pretending not to trust their own judgment. Alan Watts
growing-up book comic
I didn't really grow up a comic book fanatic. Alan Ritchson
growing late critique
A lot of the critique of our growing mechanization was actually at its strongest, and arguably at its most perceptive, during the late '60s. Alan Moore
growing bigs distrust
There's been a growing dissatisfaction and distrust with the conventional publishing industry, in that you tend to have a lot of formerly reputable imprints now owned by big conglomerates. Alan Moore
growing-up school boys
Growing up in the Boroughs, I thought I must be the cleverest boy in the world, an illusion that I was able to maintain until I got to the grammar school. Alan Moore
growing-up hands world
A world grows up around me. Am I shaping it, or do its predetermined contours guide my hand? Alan Moore
growing-up tired talking
Growing up in a Canadian household that was more British than Big Ben, I dreamed of flying to England myself and visiting the places my family never tired of talking about. I always woke up before the plane landed. Alan Bradley
growing middle standing-still
Either you're growing or you're decaying; there's no middle ground. If you're standing still, you're decaying. Alan Arkin
hardest reason
We have no idea what could have happened. The hardest part of all of this is that there is no reason for it. Roger Williams
hardest stills routes
I took the hardest possible route that you could take, and I still overcame and succeeded. David Allan Coe
hardest paying plane tickets
The plane tickets were $1,100 (each). Right now the hardest part is paying all of that off. Audrie Pattenn
hardest movies staying weight
The hardest part about making movies is staying the exact same weight every day and looking the same. Justin Timberlake
hardest stand
To stand there and do nothing on film is probably the hardest thing to do. Thomas Jane
hardest meet tried
We tried our hardest out here. We know what's on the line, and we want to be able to meet St. Thomas. Michelle Perry
hardest mostly open outfield spots three wants whoever works
We have probably two or three spots open right now. That is mostly with the outfield because the infield is pretty well set. The outfield is pretty much up for grabs so it'll be whoever works the hardest and we feel wants it the most. Rhonda Smith
hardest leaving
Leaving homosexuality was the hardest thing I've ever had to do. Anne Paulk
hardest shame sharon wilson workers
Sharon Wilson is one of the hardest workers in Ector County. It's a shame what has happened. Gene Collins
jobs words-of-wisdom deception
"There is no deception now, Mr. Weller. Tears," said Job, with a look of momentary slyness, "tears are not the only proofs of distress, nor the best ones." Charles Dickens
jobs character air
"I know quite enough of myself," said Bella, with a charming air of being inclined to give herself up as a bad job, "and I don't improve upon acquaintance..." Charles Dickens
jobs reading years
I wanted an agent who would actually sell stuff. After two British agents failed comprehensively, I was reading Locus (the SF field's trade journal) and noticed a press release about an experienced editor leaving her job to join an agent in setting up a new agency. And I went "aha!" - because what you need is an agent who knows the industry but who doesn't have a huge list of famous clients whose needs will inevitably be put ahead of you. So I emailed her, and ... well, 11 years later I am the client listed at the top of her masthead! Charles Stross
jobs reading writing
What I read: while I'm writing, I tend to go off reading fiction for relaxation - especially the challenging stuff. It's too much like the day job. Charles Stross
jobs moving careers
It's time to question a job or career move when it seems like most energy is devoted to making things appear other than what they really are. Alan Watts
jobs film hard
Film-making is a physically hard job. Alan Parker
jobs asking way
I got my first job the old-fashioned way: I took an elevator to the top floor of many buildings and walked down floor by floor on the stairs going into every firm and asking the receptionist if she knew of any jobs available. Alan Patricof
jobs two together
One thing I will say - my job gets harder and harder. The more you understand about what you are capable of, the less the instrument can do it physically. It's an inverse equation, if that's the right phrase. I just slammed those two words together. It sounded right. Alan Rickman
jobs home feet
I have a photograph at home of Fred Astaire from the knees down with his feet crossed. It's kind of inspiring because it reminds me his feet were bleeding at the end of rehearsals. Yet when you watch him, all you see is freedom. It's a reminder of what the job is about in general, not just being in musicals. Alan Rickman
notebook prayer heart
When I am praying the most eloquently, I am getting the least accomplished in my prayer life. But when I stop getting eloquent and give God less theology and shut up and just gaze upward and wait for God to speak to my heart He speaks with such power that I have to grab a pencil and a notebook and take notes on what God is saying to my heart. Aiden Wilson Tozer
notebook motivation powerful
Goddard represented a unique combination of visionary dedication and technological brilliance. He studied physics because he needed physics to get to Mars. In reading the notebooks of Robert Goddard, I am struck by how powerful his exploratory and scientific motivations were - and how influental speculative ideas, even erroneous ones, can be on the shaping of the future. Carl Sagan
notebook pages way
Looking at and shaping your own work is a very intuitive process. You see something you've written in your notebook. It's there on the page and either feels right or it doesn't, and it's hard sometimes to go beyond that and discover why it feels that way. Chad Harbach
notebook running block
Writing on a computer feels like a recipe for writer's block. I can type so fast that I run out of thoughts, and then I sit there and look at the words on the screen, and move them around, and never get anywhere. Whereas in a notebook I just keep plodding along, slowly, accumulating sentences, sometimes even surprising myself. Chad Harbach
notes record
The only record we have are your notes and your recollection. David Stern
notes rapid third
When you take two notes on the piano, an octave apart, and play them in rapid alternation, you get a third tone. Sunny Murray
notes mines
There's not a note of mine that's worth the noting. William Shakespeare
notebook running writing
I write on a computer, but I've run the complete gambit. When I was very young, I wrote with a ballpoint pen in school notebooks. Then I got pretentious and started writing with a dip pen on parchment (I wrote at least a novel-length poem that way). Moved on to a fountain pen. Then a typewriter, then an electric self-correct. Then someone gave me a word processor and I was amazed at being able to fit ten pages on one of those floppy discs. Charles de Lint
notebook growing-up artist
Growing up, I'd already decided I wanted to be a beatnik. A Bohemian poet, I thought. Or a musician. Maybe an artist. I'd dress in black turtlenecks and smoke Gitanes. I'd listen to cool jazz in clubs, getting up to read devastating truths from my notebook, leaning against the microphone, cigarette dangling from my hand. Charles de Lint
pains
I get so nervous, I get belly pains before I go on stage. Rita Ora
pains piece
It pains her terribly, A Piece of Cake. Paul Sutton
pains sharpest
It was probably one of the sharpest pains I've had. Kevin Youkilis
requirements maximum usefulness
Brokenness is God’s requirement for maximum usefulness. Charles Stanley
requirements protection equal
There is no proportional representation requirement in the Equal Protection Clause Cass Sunstein
requirements should pursuit
Whatever pursuit you undertake, the requirements should start with a love of what it is that you are pursuing. Bill Toomey
requirements maintaining dignity
Privacy is an inherent human right, and a requirement for maintaining the human condition with dignity and respect. Bruce Schneier
requirements boards fairness
Fairness is an across-the-board requirement for all our interactions with each other ...Fairness treats everbody the same. Barbara Jordan
requirements nuclear remember
We should remember that there are nations which meet more than 30 to 60% of their power requirements through the nuclear power system. Abdul Kalam
required time
Most of the time nothing much is required of directors, which is a pity. Asia Argento
required situation structural
We are not in a situation where we are required by desperation to make structural changes. Marilyn Moon
required research statement
When you research companies, they now have a statement on Y2K compliance, which they are required to give you, Ronald Hill
shifted sold
We shifted because we didn't want them sold off individually. Then we could end up with absentee landlords. Tony Johnson
shifted
The world has shifted to the palm of our hand, or a tablet. We hadn't been investing in 'Quicken' that way. Brad D. Smith
shifting side twitter version
We're on Twitter with one side of our personality, and Facebook with another, and LinkedIn with another side of our personality, and we're toggling between them. That's just a version of what an impostor does: shifting from one side of their personality to another with lightning speed. Walter Kirn
shifted society somehow took
Somehow society shifted and took these things seriously. Robert McGrath
shifting tides sucker
I'm a sucker where I love shifting tides. John Krasinski
shift
You play it one game, one shift at a time. Marty Turco
shift tremendous
There was tremendous emotion. Every shift was so emotional. Marcel Dionne
shift wisconsin
You have to give Wisconsin credit. I thought they outworked us shift in, shift out. Jamie Russell
shift team tough works
Their whole team works hard, which is tough because you can't take a shift off. Riley Nelson
top-down simplicity doe
Optimization hinders evolution. Everything should be built top-down, except the first time. Simplicity does not precede complexity, but follows it. Alan Perlis
topshop urban apparel
I love going to Topshop, Urban Outfitters and American Apparel, I'm in love with their jackets. Chloe Grace Moretz
topics until
Until a few years ago, the topics in my Ph.D. were unfashionable, but they are very popular today. Benoit Mandelbrot
top-10 planning persons
I'm planning to be the youngest contestant in the Top 32, and I'm planning to be the youngest person in the Top 10... Diana DeGarmo
topics knows
Americans know more about religion than almost any other topic. Bruce Feiler
top
She has to be (on the top of her game). Jeff Malloy
topics philosopher boring
...somehow the old philosophers could make even the most salacious topics seem boring. Brandon Sanderson
top
We didn't play well in Montreal, so this was a big win, ... Now, we're right there with everyone else (near the top of the standings at 5-2-1). Ken Hitchcock
top
We didn't play well enough and didn't do enough to win. That's the top line. Rhona Martin
training felt
I loved being back out on the pitch. Although I have not been in full training, I felt pretty good. David Ginola
training stardom
I've been in training for stardom. Bernie Mac
training mind taught
I didn't mind basic training. It taught me that something that seems impossible at the start can be achieved. Arnold Schwarzenegger
training adore hard
I simply adore the exhaustion that comes with training hard. Deena Kastor
training boeing film
I always liked show biz and got to make a few training films at Boeing. Bill Nye
training mind spirit
The word liberal distinguishes whatever nourishes the mind and spirit from the training which is merely practical or professional or from the trivialities which are no training at all. Alan K. Simpson
training java degrees
I fear - as far as I can tell - that most undergraduate degrees in computer science these days are basically Java vocational training. Alan Kay
training benefits enough
You benefit from getting in enough volume at the beginning of your training. Bernard Lagat
training age trying
We've been trying to sell cyclists of all ages and abilities on very detailed and demanding education and training programs designed to make them more like motorists. Bicyclists have shown they don't want this. What cyclists repeatedly tell us they do want is more safe places to ride, and it is time we listened to that message. Bill Wilkinson