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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics.
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online.
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services.
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts.
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters.
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here,
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof.
against arrange highest lower price sale timing weigh
We want the highest price possible. You have to weigh that against some risk: the timing of the sale and how long it could take to arrange financing. So sometimes it does make sense to take a lower price.
against bodies offense progress test
We want to test ourselves, see the progress we've made against bodies other than the UB offense and get a feel for where we are, what we need to do, and take it into the season. Tom Jones
against associate bobby discuss information jimmy man trial
There was a man who was an associate of jimmy Hoffa, who testified against Hoffa in his trial down in Tennessee. We had information from him that he and Hoffa did, in fact, discuss the planning of an assassination conspiracy against Bobby Kennedy. Louis Stokes
against both brazil match sides
The match against Brazil was football at its best. Both sides had opportunities to win the game. Michel Patini
against extremism prejudice pretend tackle
The way to tackle Muslimphobia is to tackle prejudice against Muslims. What it is not is to pretend that Islamist extremism does not exist. Maajid Nawaz
against concerned good helena quick
The one thing you're always concerned with against Helena is transition. They're quick at it, they're good at it, so you have to be good at it.
against champion fight key stand team
The other team is always going to make a run. The key to being a heavyweight champion is to fight back and stand up against the punches.
against coin continue deserve player side terrific win
The other side of the coin is that we had a terrific win against Adelaide, and every player deserve to continue on. So it is pretty tight.
against comparison easy fourth improving last note positive results year
The positive thing to note is that they actually had improving results as the year went on. But they were going against a very easy comparison -- they were down 3% in last year's fourth quarter.
assumed audience clubs girlfriend people stage worked
The people who worked at the clubs just assumed I was a tagalong girlfriend or groupie. I'd get up on stage and the audience was just like, 'Show me your tits!' I had nothing to show anyway. Gwen Stefani
assume bites individual placed point runs treatment virus wild
The point is to keep your distance. Rabies virus is serious. If a raccoon bites and runs off, we have to assume it is wild and the individual is placed in a treatment that may not have been necessary. O. Henry
assume business care frank games situation six win
We're in a situation now where we've got to take care of business with Howard and Frank Phillips. I would assume we need to probably win six games to really clinch it.
assume assumed definitely entire life people
I feel like my entire career and life, I've been judged by people who did not really know me. I definitely think that they probably were right to assume what they had assumed about me, because there was such little to go on out there. Nicki Minaj
assume draw footprint responsibility
When you take on something like your footprint on the environment, you have to say, 'Where am I going to draw the circle around my level of responsibility and then where do I assume that others will take responsibility?' Sally Jewell
assume benefits conscious fact guilty helping job work
When you're doing a job that benefits other people, it's easy to assume that they feel conscious of the fact that you're doing this work - that they should feel grateful, and that they should and do feel guilty about not helping you. Gretchen Rubin
assume case felt
We always felt we had a case geographically and politically, but what we couldn't do is assume it was going to happen.
assumed coming found surprises
We always assumed he was coming here. When we found out, it was like, 'Wow!' But nothing surprises me anymore. It's a business. Hugh Douglas
assume dropped gun hands officers punches suspect trained
When he dropped his hands to his waistband, the officers are trained to assume he's going for a weapon. That's what the punches were about. Officers who don't assume a suspect is going for a gun end up dead.
course debate human outcome shape
The outcome of that debate will shape the course of human events, Karl Rove
course last meet places track
When you've been going to places for 35 years, of course you think about it being your last time. Each track meet has something you remember.
course good huge knowing looking love
I'm not a huge shopper. I love looking good - obviously, on the golf course I like looking sharp, that's for sure. I'm just not into knowing brands.
course given gone paid reason
When he got fired, of course he was shocked. I don't think he was ever given a reason for it. They packed him up and tossed him out. If they had just paid him, he probably would have just gone his way.
course lower stay tool whether
Whether or not (the WASL) has demonstrated its effectiveness yet, I think it's still too new to rate, ... But it's important to stay the course and not lower standards, and let the tool do its work.
course enjoyed experience facilities field good great trying work
We've always got a good field here, and the course and the facilities are great. We've all enjoyed the experience here. I think it's great that they're trying to work it out to stay. Juli Inkster
course people
I've had some people tell me they're glad I'm a normal girl. Of course I'm a normal girl! Katie Featherston
course evaluate focus line mountain opportunity run ski strategy whenever
Whenever racers ski a course for the first time, the strategy is to focus on the line and to take the first run as an opportunity to evaluate how the mountain reacts.
course happened network reason talked together work
We would very much like to work together again. And we've talked about it for years. For some reason it's been elusive. She would take a movie idea to a network and I would not be available. And of course Voyager happened and it's just been - it's not been in the cards. But I'd give my eye-teeth to work with her. Kate Mulgrew
games two lawyer
Battledore and shuttlecock's a wery good game, vhen you an't the shuttlecock and two lawyers the battledores, in which case it gets too exciting to be pleasant. Charles Dickens
games words-of-wisdom delight
To bring deserving things down by setting undeserving things up is one of its perverted delights; and there is no playing fast and loose with the truth, in any game, without growing the worse for it.
games planning designer
I'm not planning a kickstarter game. And I'm not really a game designer. Charles Stross
games play self
The Universe is the game of the self, which plays hide and seek forever and ever. Alan Watts
games fire giving
Substances like LSD, which give away a secret about the nature of the social game - the human game and what underlies it - are potentially dangerous, of course, like any good thing is. Electricity is dangerous, fire is dangerous, cars are dangerous, planes are dangerous, but not so dangerous as driving on the freeway. The only way to handle danger is to face it. If you start getting frightened of it, then you make it worse. Because you project onto it all kinds of bogeys and threats which don't exist in it at all.
games boards vendetta
They say that life's a game, & then they take the board away. Alan Moore
games goal able
You don't score 64 goals in 86 games at the highest level without being able to score goals. Alan Green
games gambling casinos
The point is that it looks like gambling because the language of the game is money. Al Alvarez
games gambling cards
Hold'em is a game of calculated aggression. If your cards are good enough for you to call a bet, they are good enough to raise with.
keys people words-of-wisdom
If a dread of not being understood be hidden in the breasts of other young people to anything like the extent to which it used to be hidden in mine - which I consider probable, as I have no particular reason to suspect myself of having been a monstrosity - it is the key to many reservations.
keys imagination mind
A vile imagination, once indulged, gets the key of our minds, and can get in again very easily, whether we will or no, and can so return as to bring seven other spirits with it more wicked than itself; and what may follow no one knows. Charles Spurgeon
keys beggary idleness
Idleness is the key of beggary.
keys incomplete-knowledge choices
Given our inevitably incomplete knowledge about key structural aspects of an everchanging economy and the sometimes asymmetric costs or benefits of particular outcomes, a central bank needs to consider not only the most likely future path for the economy but also the distribution of possible outcomes about that path. The decision makers then need to reach judgment about the probabilities, costs and benefits of the various possible outcomes under alternative choices for policy. Alan Greenspan
keys risk resilience
The use of a growing array of derivatives and the related application of more-sophisticated approaches to measuring and managing risk are key factors underpinning the greater resilience of our largest financial institutions .... Derivatives have permitted the unbundling of financial risks.
keys parent seven
When I was 12, I forgot the keys to my parent's apartment. So I simply climbed up seven floors to get in. Alain Robert
keys boots way
I was very, very shocked about Cooperstown. I thought my chances were fairly good, but I tried to stay low key about it, not too high and not too low. That was the way I played, too. Al Kaline
keys mind obedience
The KEY to disciplining ourselves in the area of obedience is always keeping in mind to whom we are being obedient. Aiden Wilson Tozer
keys guy albums
I just downloaded the new Alvin and the Chipmunks album! They're the only guys that make music in my key! Chris Colfer
learning enemy safe
It is always safe to learn, even from our enemies; seldom safe to venture to instruct, even our friends. Charles Caleb Colton
learning ignorance knowledge
The greater the scientist, the more he is impressed with his ignorance of reality, and the more he realizes that his laws and labels, descriptions and definitions, are the products of his own thought. They help him to use the world for purposes of his own devising rather than understand and explain it.
learning evolution programming
Optimization hinders evolution. Alan Perlis
learning nouns programming
Any noun can be verbed.
learning thinking language
A good programming language is a conceptual universe for thinking about programming.
learning thinking knowing
A language that doesn't affect the way you think about programming is not worth knowing.
learning machines program
To understand a program, you must become both the machine and the program.
learning
I play guitar, piano, and I'm learning to play the drums. Nolan Sotillo
learning thinking brain
I think it's so important to keep learning and keep your brain active. Beverley Mitchell
momentum financial possibility
In an economy that already has lost some momentum, one must remain alert to the possibility that greater caution and weakening asset values in financial markets could signal or precipitate an excessive softening in household and business spending.
moments lifetime feels
You start to live when a moment feels like a lifetime Chris Brown
momentum narrative mosaics
Momentum, in literary mosaic, derives not from narrative but from the subtle, progressive buildup of thematic resonances. David Shields
moments
Every moment a gift: are you unwrapping yours now, and now, and now? Byron Katie
moments enough good-enough
I've had quite a few moments I've liked, so it's good enough. Bryan Ferry
moment push
We still need to push back that moment where I'd say I'm happy, ... But I'm very satisfied. Angela Merkel
moments rescue surprising
It is so often surprising, who rescues you at your lowest moments. Aimee Bender
moments bigs studios
The moment I got a very big studio, everything took off. David Hockney
moments excuse distinction
Excuse my absolute freedom. I refuse to make a distinction between any of the moments of myself. Antonin Artaud
national-security gross negligence
Gross negligence in handling national security is a felony. Bill O'Reilly
national number people playing team whenever
Whenever you can be a part of something where the number one team and number two team are playing each other on national television, it is special. How many people get that opportunity?
national operating response
We were already operating under the National Response Plan.
national sang
I sang at the Inaugural prayer service at the National Cathedral. Michael W. Smith
national persuaded reform trying unwilling
We've become persuaded that, after two years of trying to reform the national AFL-CIO, it is unwilling to change,
national spell
We're back-to-back national champions. You can't spell BCS without USC. LenDale White
national spell
We're back-to-back national champions, ... I know you can't spell BCS without USC.
national people power russian traditions
Russian democracy is the power of the Russian people with their own traditions of national self-government, and not the realisation of standards foisted on us from outside. Vladimir Putin
national people realise
What governments and people don't realise is that sometimes the collective interest - the international interest - is also the national interest. Kofi Annan
ohio people tasks
As governor of Ohio, I have an obligation to keep the 11.5 million people in Ohio safe. And we have been very effective with our Joint Terrorism Task Force, being able to make busts. Chris Christie
ohio people michigan
If you live in Ohio and you don't wear scarlet and gray now, you're an oddball. And it used to be that you could go around town even in Columbus and see a bunch of people in Michigan shirts ... And that's horrible, isn't it?. Dave Foley
ohio-state drs done
The most frightening interview I've ever done was with Dr. Lonnie Thompson of The Ohio State University on the subject of global warming. Bill Kurtis
ohio ifs
All Americans come from Ohio originally, if only briefly. Dawn Powell
ohio people voting
The failure in Ohio to have adequate voting capacity for the people who were registered and eligible to vote was an absolute denial of their right to vote. Carol Moseley Braun
ohio grew states
I grew to manhood in the Ohio State Penitentiary. Chester Himes
ohio average guy
Statistics indicate that the average American is a guy named Brian who lives in Ohio. Demetri Martin
ohio lucky right-time
I'm just a lucky slob from Ohio who happened to be in the right place at the right time. Clark Gable
ohio tuesday brave
Ohio went on alert Tuesday when a train with hazardous chemicals ran wild through the state. A brave engineer leaped aboard and brought the runaway train under control. Sounds like we've found our next FBI Director. Argus Hamilton
people may medical
It is astonishing how much more anxious people are to lengthen life than to improve it; and as misers often lose large sums of money in attempting to make more, so do hypochondriacs squander large sums of time in search of nostrums by which they vainly hope they may get more time to squander.
people solitude multitudes
A multitude of people and yet solitude.
people governing whole
My faith in the people governing is, on the whole, infinitesimal; my faith in the people governed is, on the whole, illimitable.
people words-of-wisdom selfishness
Others had been a little wild, which was not to be wondered at, and not very blamable; but, he had made a lamentation and uproar which it was dangerous for the people to hear, as there is always contagion in weakness and selfishness.
people words-of-wisdom want
Mrs. Boffin and me, ma'am, are plain people, and we don't want to pretend to anything, nor yet to go round and round at anything because there's always a straight way to everything.
people next cleanliness
Cleanliness is next to Godliness, and some people do the same by their religion.
people scary alive
I have heard it said that as we keep our birthdays when we are alive, so the ghosts of dead people, who are not easy in their graves, keep the day they died upon.
people enemy
Some people are nobody's enemies but their own
people romance wonder-woman
Superman/Wonder Woman, people expected, I guess, a lot of romance, or maybe something that wasnt emotionally deep. Who knows? Charles Soule
team people dementors
I don't like people who drain my time and energy. If you've seen the Harry Potter films, we use the term 'dementors' - people who can draw the life out of you in terms of your energy. So we eradicate the 'dementors', encourage the positive people, and that spreads around to create the team spirit we have here Alan Pardew
team cups world
I played against the Brazilians in '82, who were definitely the best team never to have won the World Cup. Alan Hansen
team cups needs
The World Cup needs a brilliant Brazilian team.
teamwork littles best-team
A German team could be quite good. But maybe they are a little bit too convinced that they are the best. Alain Prost
team people helping
It's always better to speak the language of the team. Not only for the direct contact with everyone - sometimes it also helps you to understand the mentality of the people in the team a bit better.
team frogs tadpoles
When I drove for British teams... they called me The Tadpole because I was too small to be a frog.
team compromise building
You can't always have the best team. It's always a compromise.
team numbers
There are a number of teams that would become vastly improved with Drew Bledsoe. Al Michaels
team taken miami-dolphins
The Miami Dolphins have to be taken seriously. Here's a team that seems to be jelling.
urgent
It's even more urgent than it was in these other hurricanes or tsunamis. Jan Egeland