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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
coming example money send though
We want to set the right example and send the right message. Even though this money is coming from contributions, we still think it's very important to be cost-efficient and responsible with expenses. Richard McGrath
coming good people photo saying
Pretty good, you know it's nice when you get people coming up to you saying 'Can I have a photo or an autograph'; it's a compliment, I think. Luke Pasqualino
coming concept great home leaves picked room sports understand
The great thing coming from sports is you understand the concept of a team. It leaves no room for being selfish, and that's something I picked up from home. Michael Strahan
coming emotional love motivation stories true understand until
I love my stories being multi-layered, and coming at it from different angles, so that you don't understand the film's true emotional motivation until the very end. M. Night Shyamalan
coming crash drive earnings economy fact market nice numbers ought quarter second sentiment slowing sold stable terrific third
The post-Labor Day rally, I wasn't sold on. The fact that we didn't really crash over summer, I thought was a terrific blessing. I think sentiment is going to drive the market from here. The numbers are there, the numbers have not changed. The economy has not changed, it is still good, slowing down a little bit. We've got a nice stable platform. Earnings for second quarter were fabulous. They ought to be pretty good, I think, coming in here to the third quarter. Michael Farr
coming housing negative numbers oil positive today worse
The positive today is that oil is coming down, the negative is that the housing numbers are worse than expected. James Awad
coming face move point society time turn
The point of doing all of this is so that we as a society can move forward. And the time is really coming when we really are going to turn and face the future. Mark Potok
coming defensive line pleasant practice question surprise
The pleasant surprise was how our defensive line played. One question I had coming out of preseason practice was how we would play defensively. Terry Borr
coming seeing side
We are seeing a lot of the taffeta coming back with side pleats and drapes. Carly Rager
felt
I always felt that I was a writer, that was what I had to do. Carlos Ruiz Zafon
felt invent people
I've felt a little culpable that we entrepreneurs often invent businesses just to drive people to buy more things. Lisa Gansky
felt scariest
'The Exorcist' is the scariest movie ever made. It just felt dead-on real, like you were watching the existence of the devil. M. Night Shyamalan
felt
We started off kind of sluggish. I felt like we could've come out better to play, but after we made some adjustments we were able to get things going. Ledawn Gibson
felt series
From the very beginning I felt that I would do a series, Barnett Newman
felt good momentum
We actually felt we had the momentum after that. It was good for our offense. Matt Hasselbeck
felt proper
We always felt we did the proper thing. Stan Clark
felt fitted movement
We always felt like we've never specifically fitted in with anyone; there's never been a movement surrounding what we're doing. Shirley Manson
felt finish game good guys healthy injured matter outcome season
We have to finish the season on a good note. It doesn't matter what the outcome of the game is, but we have to feel good about ourselves. I don't think we felt like that tonight. We have a lot of guys who are injured so we need to get healthy and ready. Petr Sykora
football violent fascists
I don't do football. (Grew up in Leeds in the 1970s. Football there was indellibly associated with the National Front, i.e. violent fascist skinheads.) Charles Stross
football league should
I tried to push him away with my head. I apologise to everyone. I should not have got involved in it. Alan Pardew
football league noise
Shut your noise, you old c***! Alan Pardew
football zero games
How on earth can otherwise sensible people get so involved in a football game? You could measure the lasting impact on the lives of the people who played it at just about zero. Alan Page
football successful player
The way to be successful is through preparation. It doesn't just happen. You don't wake up one day and discover you're a lawyer any more than you wake up as a pro football player. It takes time. Alan Page
football philosophy thinking
I think if Tottenham are going to be top four side, the fans and the club will need to get away from the philosophy of 'pretty football', that's got to go. Alan Hansen
football laughing missing
I don't miss playing football, but I do miss going into the dressing room every day and having a laugh. Alan Hansen
football blow watches
Phil Dowd checks his whistle and blows his watch. Alan Green
football playing-football commentators
Ziege hits it high for Heskey who isn't playing Alan Green
further issues promoting solutions start step
We want to take it a step further and start promoting some of the solutions to not only the short-term issues but also the long-term solutions. Bryan Hassler
further joint preparing teams
We are preparing for the joint team, which is going much further than just two teams parading together. Jacques Rogge
further mark published reporting speaks stand stories sure throughout
We stand by the reporting that Mark and Lance did throughout this story and in all the stories that were published in the paper. And if and when Mr. Conte speaks further about this, I'm sure we'll report about that as well. Phil Bronstein
further gain ira tactic
This (The IRA plan) is just a further delaying tactic to gain further concessions. R. Robinson
further information matter provided review study
We're going to study the matter further and review all the information that will be provided to our office. Alia Faraj
further indication trying wrong
When we conducted a further investigation of his so-called hospitalization over the weekend, the indication was they didn't think anything was wrong with him and they were trying to get him out the door. Todd Lewis
further hands heights higher ordinary people perform push teams-and-teamwork towards
Working together, ordinary people can perform extraordinary feats. They can push things that come into their hands a little higher up, a little further on towards the heights of excellence. Source Unknown
further gone sweet
We're in the sweet 16. We've gone a lot further than we thought we would. Drew Mitchell
further less likely sales slow
With Vista further out in the future, sales are less likely to slow down now. Charles Smulders
games two lawyer
Battledore and shuttlecock's a wery good game, vhen you an't the shuttlecock and two lawyers the battledores, in which case it gets too exciting to be pleasant. Charles Dickens
games words-of-wisdom delight
To bring deserving things down by setting undeserving things up is one of its perverted delights; and there is no playing fast and loose with the truth, in any game, without growing the worse for it. Charles Dickens
games planning designer
I'm not planning a kickstarter game. And I'm not really a game designer. Charles Stross
games play self
The Universe is the game of the self, which plays hide and seek forever and ever. Alan Watts
games fire giving
Substances like LSD, which give away a secret about the nature of the social game - the human game and what underlies it - are potentially dangerous, of course, like any good thing is. Electricity is dangerous, fire is dangerous, cars are dangerous, planes are dangerous, but not so dangerous as driving on the freeway. The only way to handle danger is to face it. If you start getting frightened of it, then you make it worse. Because you project onto it all kinds of bogeys and threats which don't exist in it at all. Alan Watts
games boards vendetta
They say that life's a game, & then they take the board away. Alan Moore
games goal able
You don't score 64 goals in 86 games at the highest level without being able to score goals. Alan Green
games gambling casinos
The point is that it looks like gambling because the language of the game is money. Al Alvarez
games gambling cards
Hold'em is a game of calculated aggression. If your cards are good enough for you to call a bet, they are good enough to raise with. Al Alvarez
guy wish littles
The wealth is ultimately just a relative thing. As a person with little money and little more needs to rich guys money but really wishes Charles Caleb Colton
guy trying way
I try to find a way that the other guy hasn't thought of using a sound or a sample. Alan Parsons
guy bills kind
Bill Clinton strikes me as the kind of guy who goes wherever the polls lead him, rather than leading the polls. Al Sharpton
guy athletic actors
I'm an athletic actor. I'm known for my action; I'm a guy who does my own stunts on screen. Akshay Kumar
guy naked would-be
I'm the kind of guy who would say, "Yeah, I'll do that!," and then, when it came down to it, I would be absolutely petrified. Those days have passed me by, but I would do it. If it meant that I was in a scene naked with a woman, or anybody romantic, I'd be into it. Chris Bauer
guy phrases east
Tommy's [Gamble] an East Coast guy, so he kind of talks fast and in quick statements and phrases, so I understood him and he understood me, and we just hit it off. Chip Kelly
guy brain trying
I'm trying to avoid any more asshole roles, at least for a little bit. The main criteria for me when choosing a project is a good director. I just want to work with these guys that I admire because I do want to direct my own films one day, and I want to pick their brains to see what their process is like, and see what I can take from that. Dave Franco
guy kind
I'm a small shifty kind of guy. Dave Franco
guy way mature
I'm happier in the way a guy gets happier when he starts to mature. It doesn't make things easier, but I'm so much better at handling them. Dave Chappelle
maybe reason smile though understand waking
We want to show that even though someone may be different on the outside, they still understand how you feel. Maybe the same thing makes you smile or is your reason for waking up. Dana Martell
maybe people recovery
We are going to see some recovery in the economy, but maybe not as much as some people expected. Andrew Wallace
maybe sure top
We still need a point, maybe two, to be sure of being in the top four. Richard Money
maybe-tomorrow office president
We are seeing at the Republican National Committee a phenomenon that is worth noting this week; maybe today, maybe tomorrow, maybe Wednesday, we will have a million first time donors since the president took office. Ed Gillespie
maybe mike mitchell player productive replace somewhat talented though trying
We were trying to replace some very talented kids. He was trying to replace the player of the year, which is never easy. Maybe our expectations were not what they should have been. I think he had a productive year, even though it was somewhat inconsistent to Mike Mitchell and Gavin Hoffman. Al Bagnoli
maybe
We are getting better with each game. Maybe we are peaking at the right time. Kendall Mills
maybe
We're going to have to put 12 of them out there, ... maybe some snipers, too. Bill Miller
maybe tough toughest
We know we're in for a tough one, maybe the toughest one all year. Mike Shula
maybe
We know D.J. is out indefinitely and maybe out for the season. Mike Davis
next generations products
The next generation product almost never comes from the previous generation. Al Ries
next causes steps
I love to just go to the movies, watch movies, listen to the scores and all that 'cause that's, like, the next step for me. Akon
next
We want to see who we're going to keep around next season. Mike Butters
next want knows
I don't want to go bald, I don't know what's coming up next. Chris Cooper
next performances improving
Everything I do is geared towards improving my next performance. Carolina Kluft
next performance sequels stock store
The performance of the stock is going to come down to the movies. It's that simple. And there are no sequels in store for next year. David Miller
next percent spending total
We are making a dent, but we are not going to be at 10 percent of total spending by next year. Greg Stuart
next night parking spent until
We spent the night at a parking lot until the next morning. David Foster
next faces realization
In the face of impermanence, if your next thought is good, this is what we call the realization body. Bill Porter
nice lying thinking
You can act truthfully or you can lie. You can reveal things about yourself or you can hide. Therefore, the audience recognizes something about themselves or they don't -- You hope they don't leave the theatre thinking that was nice...now where's the cab?' Alan Rickman
nice being-nice sometimes
Sometimes doing the forbidden can be nice. Alain Robert
nice character play
I don't really worry about the size of the part much any more. It's nice to have more time to work on the character, and to have big scenes to play. But if there's something playable there, and if it's interesting to do, then that's nice. Alan Alda
nice nasty
Be as nice as possible and as nasty as necessary. Al Neuharth
nice very-nice
I'm the best there is at what I do but what I do best isn't very nice Chris Claremont
nice thinking careers
I am aware that I have been incredibly fortunate in my life to work with the people that I have worked with and pursue the projects that I have been able to do. There are so many films that I have done that I really, as a film person, as a film fan, that I like. And that is a nice place to think of a career in. Chiwetel Ejiofor
nice believe way
I don't believe that jazz will ever really die. It's a nice way to express yourself. Chet Baker
nice past guy
Recently I've been looking for something new. The past few projects I've worked on, I keep getting cast as the asshole. I promise I'm a nice guy and not the asshole that everyone keeps seeing. Dave Franco
nice thinking challenges
I think I'm a very very nice director. Very supportive, very nurturing. I definitely try to challenge my actors but I think I'm very supportive. David Schwimmer
normal
How can you be afraid of women?” “Those ain’t normal women. Dave Barry
normal being-a-woman taboo
All the things that are taboo are the things that are not normal, and all the things that are not normal are the things that are exclusively about physically being a woman. Caitlin Moran
normal shot today
We've all bowled at Cadillac, but today wasn't like the normal Cadillac. It was a very playable shot but just a little different. Scott Carpenter
normal played settled
We started off very poorly. But we know what we can do. We just settled down and played our normal game. Joe Johnson
normal particular produce quantities traces
Coproporphyrin in particular is widespread; traces are present in normal urine and also in yeast. In special cultures, yeast can be made to produce considerable quantities of coproporphyrin. Hans Fischer
normal persons
I had to bring myself back down to being a normal person again. Aidan Quinn
normal appetite wells
I have an appetite for the normal in my life, as well as the abnormal. Benedict Cumberbatch
normal possible
We want it to be as normal as possible for the kids. Max Miller
normal possible setting
We want it be as normal a setting as possible and not have them stigmatized as being retarded. Jim Hall
obviously question record
We have no idea what this woman's record is about. She's obviously an accomplished attorney. The question is what does she believe. We have no idea, ... This Week. Howard Dean
obviously shifting
We're going to obviously put a lot of thought into this. You don't want to keep shifting in and out, especially through intersections. Billy Coleman
obviously people social thinking twitter
Being on Twitter and social media, you obviously get to see a lot more of what people are thinking of you and of your show. Eliza Taylor
obviously
Bram Stoker's 'Dracula,' in my reading, is really obviously about disease and our relation to disease. Eula Biss
obviously
The championship, in my eyes, in television, is obviously an Emmy. Keyshawn Johnson
obviously
We won, so obviously I feel very good. Bruce Chen
obviously sauce sundays
Some days I'll cook, and then some days my wife will cook. For me, obviously on Sundays a lot of times we do the sauce and the meatballs and pasta, the whole thing. Joey Fatone
obviously worked
Shale is one answer to the U.K.'s energy problem, and it has obviously worked extraordinarily well in America. Jim Ratcliffe
obviously
She is obviously distraught and is at an undisclosed location. Ron Walker
steps backing-up steady
History has spurts and then is steady, and then maybe even backing up a step, and then forward again. Alan Bean
step
We want to take a step forward. There's some worries. But you just go in there and play. David Cornwell
steps surprise reader
I really like it when you can step outside of what's come before and find a surprise for the reader and find a surprise for yourself. Dave Gibbons
steps tough push-yourself
You take yourself to a place where you've got absolutely nothing left and then you find out you have to push yourself one more step. That's a tough place to be in. Bryan Clay
steps comfort grows
It is only when You really STEP OUT of Your comfort zone that You GROW. Bear Grylls
steps problem illegal
Illegal immigrants are already a very big problem for us. We are already taking big steps to disallow illegal immigrants from coming in. Antonis Samaras
steps commencement experiments
One failed experiment is one step closer to Success Denzel Washington
steps should
Until we see what we are, we cannot take steps to become what we should be. Charlotte Perkins Gilman
steps looks hard
It's hard to see things when you're too close. Take a step back and look. Bob Ross