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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
alarming building ironic less paid people protect works
We find it ironic and alarming that the people who protect the building are paid less than everyone else who works at the building. Matt Nerzig
alarming apparently british chief common courtesy home mess painted port portrait rarity
'MaerskKendal' is a rarity with its British flag, the 'LONDON' home port painted on its bow, its two British chief officers, and its portrait of the queen in the mess room, apparently common courtesy on British ships, but a little alarming to me. Rose George
alarming conflicts countries foreign united
It's alarming that military intervention in internal conflicts in foreign countries has become commonplace for the United States. Vladimir Putin
alarming challenges face habitat increase pattern raises rates reduced risk species
The pattern raises the alarm, however, that these species face two challenges that increase the risk of extinction: habitat destruction, which is occurring at alarming rates in the tropics, and reduced pollinator activity. Susan Mazer
alarming challenges face habitat increase pattern raises rates reduced regions risk species
The pattern raises the alarm, however, that species in species-rich regions face two challenges that increase the risk of extinction: habitat destruction, which is occurring at alarming rates in the tropics, and reduced pollinator activity. Susan Mazer
alarming barely climb enjoyed exhausted home knew life physical stairs stunts taking totally
I'd be totally exhausted by mid-afternoon, and I could barely climb the stairs at home. It was particularly alarming because all my life I'd enjoyed doing all my own stunts in shows, taking on every physical challenge. Yet suddenly, I'd become like a very old man. I knew something was wrong, but I had no idea what. Michael Crawford
alarming barbie life looked people spend time voice
I think, for a long time, people just did not know what to do with me. I looked like a Barbie doll, and then I had this voice like I spend my life in a bar, and I said things that were alarming and had ideas that didn't make sense. Sharon Stone
alarming cannot particular perverse seems simply
That's the thing about fiction writers: what seems alarming or particular or perverse about them is simply the shape of their brain - they cannot be otherwise. Zadie Smith
alarming changing
Politically, economically and technologically, the world is changing at an unprecedented and sometimes alarming pace. William Cohen
declines further months production quick rebound sales unless weakness
Unless there is a quick rebound in sales, this suggests further weakness in production and declines in inventories over the months ahead. Steven Wood
decline frankly market north people profitable sharp
With their sharp decline in market share, they have frankly got too much capacity, too many plants, too many people to be profitable in North America. David Healy
decline employment expecting next volume year
We're expecting a decline in employment because we expect the volume of originations to decline pretty significantly next year -- 20 percent. Orawin Velz
decline forced grips growth likely market seek shift steep
Vendors are likely to see a fundamental shift in the market as they come to grips with the steep decline in mature-market desk-based growth and are forced to seek growth in other market segments. George Shiffler
declines feeling glad lower main needs percentage prior problem serious workers
We're glad that the percentage is lower than the prior year. But our main feeling is that when you have one out of every 10 workers having these significant declines in cholinesterase, you've got a serious problem that needs to be addressed. Carol Dansereau
decline killer seriously support sustain taking whales work
We are taking the decline of these killer whales seriously and we will work to sustain and support this population. Bob Lohn
declines downside issue names percent seen year
We've seen this how many times already this year -- three? ... A lot of these names could have 50 percent downside from here. Our big issue is, are the sequential declines (in revenue) over? I'd say no. Daniel Niles
decline direct gets government lead levels seen
We've seen lead levels dramatically decline in kids, PCB (polychlorinated biphenyl) levels decline, all because of direct government intervention that gets these out of the environment. Jane Houlihan
decline equity european following happen huge markets stocks
There is a lot of following stocks around today. That was the big thing after the huge decline in the European equity markets - there was a lot of nervousness about what would happen in the U.S. Michael Cloherty
democratic diplomatic
I've always been completely autocratic. I've never learned to be diplomatic or democratic. Alan Parker
democratic message sure venezuela witness
My message to France and Europe is that we will make sure Venezuela won't witness the rise of another Pinochet. And we will do it the democratic way. Nicolas Maduro
democratic drawings poetry side work
Prose, poetry, and drawings stand side by side in a very democratic way in my work. Gunter Grass
democratic snowstorms
Few things are as democratic as a snowstorm. Bernard Williams
democratic
You cannot use the democratic process for the procurement of excellence. Kevin McCloud
democratic major middle permanent propose public reduction suspect
A Democratic president should propose a major permanent tax reduction on the middle class and working class. I suspect most of the public would find this attractive. Robert Reich
democratic egyptians freedom groups helping human institute move mubarak national piece politics practices raids republican respect rights toward
The raids on Freedom House, the National Democratic Institute and International Republican Institute, the Adenauer Foundation, and other groups helping Egyptians move toward respect for democratic politics and human rights were of a piece with the practices of Hosni Mubarak - only bolder and more repressive. Elliott Abrams
democratic figure moves primary remains
She remains a controversial figure when she moves out from the Democratic primary sweepstakes. Lee Miringoff
democratic given involved lip major minorities party service terms vote
Minorities give their vote to the Democratic Party, and the Democratic Party has given them lip service in terms of being involved in the party and in being major players. Lynn Swann
lessons shapes pay
Everything shapes you to be the person you are today. Sometimes hard lessons pay off dividends. Al Jourgensen
lessons matter facts
No matter what you do, you can never please everyone. And that was the hardest lesson to learn. In fact, I'm still learning it. Chris Colfer
lessons painful evolve
Unless you continually work, evolve, and innovate, you'll learn a quick and painful lesson from someone who has. Cael Sanderson
less looking toward
We are looking less favorably toward 2016 bidding at this moment, Peter Ueberroth
less mean point push start sure year
We are at the point of the year where if you push him back, it could mean one less start at the end of the year. We need to make sure that he can pitch. If we do push him back, we want to make sure we have the matchups we need at the end of the season. Mike Scioscia
lessons used teach
I used to teach dance lessons. Eartha Kitt
lessons rewards hell
The lesson is, the rewards in life don't always go to the biggest, or the bravest, or the smartest. The rewards go to the dogged; and when your going though hell, to the person who just keeps going. Bear Grylls
lessons-to-be-learned alive process
Success is a process that continues, not a status that you reach. If you are alive, there are lessons to be learned. Denis Waitley
lessons firsts given
To know ourselves, is agreed by all to be the most useful Learning; the first Lessons, therefore, given us ought to be on that Subject. Eliza Haywood
people may medical
It is astonishing how much more anxious people are to lengthen life than to improve it; and as misers often lose large sums of money in attempting to make more, so do hypochondriacs squander large sums of time in search of nostrums by which they vainly hope they may get more time to squander. Charles Caleb Colton
people solitude multitudes
A multitude of people and yet solitude. Charles Dickens
people governing whole
My faith in the people governing is, on the whole, infinitesimal; my faith in the people governed is, on the whole, illimitable. Charles Dickens
people words-of-wisdom selfishness
Others had been a little wild, which was not to be wondered at, and not very blamable; but, he had made a lamentation and uproar which it was dangerous for the people to hear, as there is always contagion in weakness and selfishness. Charles Dickens
people words-of-wisdom want
Mrs. Boffin and me, ma'am, are plain people, and we don't want to pretend to anything, nor yet to go round and round at anything because there's always a straight way to everything. Charles Dickens
people next cleanliness
Cleanliness is next to Godliness, and some people do the same by their religion. Charles Dickens
people scary alive
I have heard it said that as we keep our birthdays when we are alive, so the ghosts of dead people, who are not easy in their graves, keep the day they died upon. Charles Dickens
people enemy
Some people are nobody's enemies but their own Charles Dickens
people romance wonder-woman
Superman/Wonder Woman, people expected, I guess, a lot of romance, or maybe something that wasnt emotionally deep. Who knows? Charles Soule
polls persons left
Every poll about the Left, the Right, and happiness reveals that the farther left one goes, the less happy the person is likely to be. Dennis Prager
polls reality
Today, we'll make reality what the polls have been saying. Oscar Arias
polls public
We have too many politicians who are poll-driven to excess. Polls are important. You've got to know what the public is thinking, but you can't let them drive you completely. Rudy Giuliani
polls urge
I would urge patrons to go to the polls and vote, ... I think it's important to participate in this process. Tony Wood
polls
It is not they who will decide, but we when we go to the polls on Sunday, Gerhard Schroeder
polls
The media, the polls and our legislatures fortunately have short attention spans. John Gutfreund
polls rankings
It's early, those polls and rankings are going to change. Herb Sendek
polls swayed terribly
I'm not terribly swayed by polls at this point. Jennifer Duffy
polls lawmakers should
You should go to the polls, organize yourself. But once lawmakers are chosen, they must be respected. Lech Walesa
trust honesty business
I have known a vast quantity of nonsense talked about bad men not looking you in the face. Don't trust that conventional idea. Dishonesty will stare honesty out of countenance any day in the week, if there is anything to be got by it. Charles Dickens
trust dark light
I would sooner walk in the dark, and hold hard to a promise of my God, than trust in the light of the brightest day that ever dawned. Charles Spurgeon
trust disappointment world
Trust in God alone, and lean not on the needs of human help. Be not surprised when friends fail you; it is a failing world. Never reckon upon immutability in man: inconstancy you may reckon upon without fear of disappointment. Charles Spurgeon
trust-issues promise dare
Trust in the person's promise who dares to refuse what they fear they cannot perform. Charles Spurgeon
trust-yourself mistrust paralyzed
If you cannot trust yourself, you cannot even trust your mistrust of yourself - so that without this underlying trust in the whole system of nature you are simply paralyzed Alan Watts
trust data function
It is better to have 100 functions operate on one data structure than to have 10 functions operate on 10 data structures. Alan Perlis
trust cutting ties
We do not trust the goodwill of the U.S. They have cut the ties. Akbar Hashemi Rafsanjani
trust military believe
I believe the main solution is to gain the trust of Europe and America and to remove their concerns over the peaceful nature of our nuclear industry and to assure them that there will never be a diversion to military use. Akbar Hashemi Rafsanjani
trust house cleaning
I love cleaning the house. I'd never have a cleaner - I wouldn't trust them to do it. Chloe Sevigny
worry energy-of-the-universe eternal
Basically, there is simply nothing to worry about, because you yourself are the eternal energy of the universe. Alan Watts
worry people way
It used to worry me what people said about me. I'm learning not to worry as much. Sometimes you feel critics are wrong all the time, but I don 't take objection to it, because that's the way it goes. They can be wrong, they can be right. They can be cruel, they can be kind. Al Pacino
worry disorder severe
One of the things is that in times of severe disorder, you can't worry about the dead, only the living. Darren Shan
worry weight
He had kept his head, kept his health and his strength, bearing up under a weight of work and worry that only a few could have carried. David McCullough
worry tennis doe
No one is friends with Hewitt and he does not worry me at all. David Nalbandian
worry fit fashionable
Even if it doesn't fit the woman, like, let's say a very short skirt, and the woman doesn't have the legs or the height to wear the skirt, but she has to wear it because it's fashionable. Don't do it! If it doesn't look good on you, don't worry about it. Carolina Herrera
worry
Don't worry about things you cannot alter Catherine the Great
worry recognizing
I never, ever worry about anybody recognizing me. Charlie Bewley
worry president cabinets
Ron Paul is not going to be president, so we don't have to worry about who's going to be in his cabinet. Charles Krauthammer