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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
aging answers dedicated delay develop extending finding glenn healthful human mechanisms molecular normal paul process proud thereby understand
We are proud to be teaming up with Mr. Glenn and the Glenn Foundation. Like us, Paul is dedicated to finding the molecular answers to the aging process so we can understand the mechanisms of normal aging and develop interventions to delay its onset and decline, thereby extending the healthful years of human life. David Sinclair
aging children follow generation gives guilt heed husbands jokes laugh listened looking louder permission small totally voices women
We are a generation of women that has listened to the much louder voices of parents, teachers, employers, husbands and children while our own voices were small or muffled or totally ignored. Aging Out Loud gives us permission to not only listen to that voice but heed its warnings, laugh at its jokes and follow its directions, without guilt and without looking back. Connie Stevens
aging challenge confront countries europe good relative shape
We're in much better shape to confront the aging challenge than the countries of continental Europe or Japan. But good shape is a relative statement. Richard Jackson
aging nations
As a nation, we have never embraced aging, Denise Lewis
aging embrace hollywood peace pressure supposed wiser work younger
Aging in Hollywood sucks. There's always so much pressure to look way younger than you are, and everyone's watching! I'd like to embrace getting older, because it's kind of inevitable. The different, wiser me, to be at peace with how I look and I'm supposed to look - it's a work in progress. Lisa Vidal
aging define inspires living people stuff
We write about the stuff that inspires us: relationships, traveling, aging and living in general. Those are the things that define people as they are. Scott Terry
aging attention begin care cost essential future general loved pay planning public until
With the onset of the aging demographic revolution, it is essential that the general public begin planning for their future care requirements. Unfortunately, most of us pay little attention to the cost of such care until we or our loved ones need it. Bill Novelli
aging permission knows
Life, the permission to know death. Djuna Barnes
aging myth growing-older
Now is the time to become a myth. Diane von Furstenberg
animal safety giving
Subtlety will sometimes give safety, no less than strength; and minuteness has sometimes escaped, where magnitude would have been crushed. The little animal that kills the boa is formidable chiefly from its insignificance, which is incompressible by the folds of its antagonist. Charles Caleb Colton
animal mind facts
You can only form the minds of reasoning animals upon Facts: nothing else will ever be of any service to them. Stick to Facts, sir! Charles Dickens
animal lions sulky
Quadruped lions are said to be savage, only when they are hungry; biped lions are rarely sulky longer than when their appetite for distinction remains unappeased. Charles Dickens
animal lust use
...the whole universe is through and through the playing of love in every shade of the word's use, from animal lust to divine charity. Alan Watts
animal envy simplicity
At times almost all of us envy the animals. They suffer and die, but do not seem to make a "problem" of it. Alan Watts
animal technology vegetables
"It is essential to understand this point thoroughly: that the thing-in-itself, whether animal, vegetable, or mineral, is not only unknowable-it does not exist. This is important not only for sanity and peace of mind, but also for the most "practical" reasons of economics, politics, and technology.. This is not to say only that things exist in relation to one another, but that what we call "things" are no more than glimpses of a unified process. Certainly, this process has distinct features which catch our attention, but we must remember that distinction is not separation." Alan Watts
animal acting kind
I'm very aware that when one is acting in the theater, you do become kind of animal about it. And you're reliant on instincts rather than tact a lot of the time. Alan Rickman
animal rocks rock-n-roll
Rock n Roll Animal, the live album, is one of the greatest live albums out there. It was a huge influence on me. Al Jourgensen
animal essence abuse
The abuse of a harmless thing is the essence of sin. Aiden Wilson Tozer
birth remember importance
When a person feels disposed to over estimate his own importance, let him remember that mankind got along very well before his birth, and that in all probability they will they will get along very well after his death. Charles Simmons
birthday tin cold
Here I sit, alone at 60, Bald and fat and full of sin Cold the seat, and loud the cistern As I read the (Harpic) (Lysol) tin Alan Bennett
birthday children nice
My best kiss was on stage. Kelly Rowland from Destiny's Child gave me a really nice soft kiss on my lips during a performance on my birthday. It was amazing. Chris Brown
birthday mom fashion
My mom won't let me buy high-fashion stuff unless it's TK Maxx or a birthday occasion. Chloe Grace Moretz
birthday nice party
It's odd the things that people remember. Parents will arrange a birthday party, certain it will stick in your mind forever. You'll have a nice time, then two years later you'll be like, 'There was a pony there? Really? And a clown with one leg?' David Sedaris
birthday sex eye
The information encoded in your DNA determines your unique biological characteristics, such as sex, eye color, age and Social Security number. Dave Barry
birthday people age
Thanks to modern medical advances such as antibiotics, nasal spray, and Diet Coke, it has become routine for people in the civilized world to pass the age of 40, sometimes more than once. Dave Barry
birthday age today
Today, you're 50. Now we can round your age up to 100! Happy 50th birthday! Dave Barry
birthday simple men
The simple truth is that balding African-American men look cool when they shave their heads, whereas balding white men look like giant thumbs. Dave Barry
book night men
Although I am an old man, night is generally my time for walking. Charles Dickens
book reading writing
There are books of which the backs and covers are by far the best parts. Charles Dickens
book knowledge men
Mathematicians have sought knowledge in figures, Philosophers in systems, Logicians in subtleties, and Metaphysicians in sounds. It is not in any nor in all of these. He that studies only men, will get the body of knowledge without the soul, and he that studies only books, the soul without the body. Charles Caleb Colton
book reading advice
When in reading we meet with any maxim that may be of use, we should take it for our own, and make an immediate application of it, as we would of the advice of a friend whom we have purposely consulted. Charles Caleb Colton
book merit lovers
We should choose our books as we would our companions, for their sterling and intrinsic merit. Charles Caleb Colton
book reading writing
Some read to think, these are rare; some to write, these are common; and some read to talk, and these form the great majority. Charles Caleb Colton
book reading writing
Many books require no thought from those who read them, and for a very simple reason; they made no such demand upon those who wrote them. Charles Caleb Colton
book writing companion
With books, as with companions, it is of more consequence to know which to avoid, than which to choose, for good books are as scarce as good companions, and in both instances, all that we can learn from baad ones is, that some much time has been worse than thrown away. Charles Caleb Colton
book men soul
He that studies only men will get the body of knowledge without the soul; and he that studies only books, the soul without the body. Charles Caleb Colton
caring thinking gentleman
Do you want to be a gentleman, to spite her or to gain her over? Because, if it is to spite her, I should think - but you know best - that might be better and more independently done by caring nothing for her words. And if it is to gain her over, I should think - but you know best - she was not worth gaining over. Charles Dickens
caring clouds light
The cloud of caring for nothing, which overshadowed him with such a fatal darkness, was very rarely pierced by the light within him. Charles Dickens
caring awkward care
I don't care if I'm cool or not. I've always been an awkward person anyway. Chris Carrabba
caring should-have people
If you're living in the community and you own your local businesses and you're engaged in the local economy you should have a definite interest in the strength and health of your community, the caring relationships that bind people together. David Korten
caring care realizing
I realize that I'm generalizing here, but as is often the case when I generalize, I don't care. Dave Barry
caring thinking wind
What distinguishes our species is thought. The cerebral cortex is in a way a liberation. We need no longer be trapped in the genetically inherited behavior patterns of lizards and baboons: territoriality and aggression and dominance hierarchies. We are each of us largely responsible for what gets put in to our brains. For what as adults we wind up caring for and knowing about. No longer at the mercy of the reptile brain we can change ourselves. Think of the possibilities. Carl Sagan
caring hair mad
I remember the day I saw my hair was thinning. I don't remember caring much. I don't care. It's just hair. It never bothered me much. I was pretty young, too. And it happened and is happening very slowly. I have a feeling dead people get really mad when we complain about losing hair. Louis C. K.
caring helping-others government
What volunteers bring is the human touch, the individual, caring approach that no government program, however well-meaning and well- executed, can deliver. Edward James Olmos
caring compassion self
Caring for myself is not self-indulgence, it is self-preservation, and that is an act of political warfare. Audre Lorde
children pride men
There is not a manufacturer or tradesman in existence, who would not employ a man who takes a reasonable degree of pride in the appearance of himself and those about him, in preference to a sullen, slovenly fellow, who works doggedly on, regardless of his own clothing and that of his wife and children, and seeming to take pleasure or pride in nothing. Charles Dickens
children father heart
Father Time is not always a hard parent and though he tarries for none of his children, often lays his hand lightly upon those who have used him well; making them old men and women inexorably enough, but leaving their hearts and spirits young and in full vigor. With such people the gray head is but the impression of the old fellow's hand in giving them his blessing, and every wrinkle but a notch in the quiet calendar of a well-spent life. Charles Dickens
children sea play
There is nothing--no, nothing--innocent or good, that dies and is forgotten; let us hold to that faith or none. An infant, a prattling child, dying in the cradle, will live again in the better thoughts of those that loved it, and play its part through them in the redeeming actions of the world, though its body be burnt to ashes or drowned in the deep sea. Charles Dickens
children parenting expectations
In the little world in which children have their existence, whosoever brings them up, there is nothing so finely perceived and so finely felt, as injustice. Charles Dickens
children grieving two
It always grieves me to contemplate the initiation of children into the ways of life when they are scarcely more than infants. It checks their confidence and simplicity, two of the best qualities that heaven gives them, and demands that they share our sorrows before they are capable of entering into our enjoyments. Charles Dickens
children father past
How strange it is that we of the present day are constantly praising that past age which our fathers abused, and as constantly abusing that present age, which our children will praise. Charles Caleb Colton
children knowledge enemy
Religion has treated knowledge sometimes as an enemy, sometimes as a hostage; often as a captive and more often as a child; but knowledge has become of age, and religion must either renounce her acquaintance, or introduce her as a companion and respect her as a friend. Charles Caleb Colton
children gambling parent
Gaming is the child of avarice, but the parent of prodigality. Charles Caleb Colton
children heaven wish
Avarice begets more vices than Priam did children and like Priam survives them all. It starves its keeper to surfeit those who wish him dead, and makes him submit to more mortifications to lose heaven than the martyr undergoes to gain it. Charles Caleb Colton
couple hands people
It was a good thing to have a couple of thousand people all rigid and frozen together, in the palm of one's hand. Charles Dickens
couple men hands
I am a neat hand at cookery, and I'll tell you what I knocked up for my Christmas-eve dinner in the Library Cart. I knocked up a beefsteak-pudding for one, with two kidneys, a dozen oysters, and a couple of mushrooms thrown in. It's a pudding to put a man in good humour with everything, except the two bottom buttons of his waistcoat. Charles Dickens
couple hands want
I don't want to permanently damage myself! On the other hand, a couple of days off the keyboard tends to make things somewhat better. Charles Stross
couple may terrible
I'm told that a couple of my Russian translations are just plain terrible, though, and there may be others. Charles Stross
couple years my-boyfriend
Over the last couple of years, I've really worked toward balancing my life out more, having a little bit more time with friends, family and my boyfriend. There was a period of time when they were way down the list. It was all about music and touring and if everything fell by the wayside, so be it. Alanis Morissette
couple majority adaptation
I increasingly fear that nothing good can come of almost any adaptation, and obviously that's sweeping. There are a couple of adaptations that are perhaps as good or better than the original work. But the vast majority of them are pointless. Alan Moore
couple guitar burritos
I played guitar. I've always considered myself an actor, but I wasn't making a living as an actor. So I was in a couple of folk groups that managed to keep me in underwear and burritos. Alan Arkin
couple moving done
There are times when I am directing, and there are a couple of moments I didn't get the way I wanted, but I know I still have other angles to shoot and I have to be done by noon; I move on. Alan Ball
couple believe next
I still believe Emmitt has enough left in the tank to be a productive back over the next couple of seasons. Al Michaels
family blood giving
Family not only need to consist of merely those whom we share blood, but also for those whom we'd give blood. Charles Dickens
family government community
The family is the most basic unit of government. As the first community to which a person is attached and the first authority under which a person learns to live, the family establishes society's most basic values. Charles Caleb Colton
family philosophy character
Accidents will occur in the best-regulated families; and in families not regulated by that pervading influence which sanctifies while it enhances... in short, by the influence of Woman, in the lofty character of Wife, they may be expected with confidence, and must be borne with philosophy. Charles Dickens
family father son
A father's holy life is a rich legacy for his sons. Charles Spurgeon
family cooking cooking-and-love
I love cooking for myself and cooking for my family. Al Roker
family religious age
I grew up in a very religious family. I could read the Qu'ran easily at the age of five. Akhmad Kadyrov
family kids night preach pride thursday together worry
We want the kids to take pride in the Lely brand. We preach family and Thursday night we were all together and we didn't have to worry about where they were. Chris Metzger
family son said
She said I do on day 482, and gave me a son on day 761. Chris Cagle
family checks shows
I tend to show everything I do to my family, to check they won't be offended. David Sedaris
history who-we-are way
History is a guide to navigation in perilous times. History is who we are and why we are the way we are. David McCullough
history want done
No harm's done to history by making it something someone would want to read. David McCullough
history social shank
History is the shank of the social sciences. C. Wright Mills
history lafayette might
For women, history does not exist. Murasaki, Sappho, and Madame Lafayette might be their own contemporaries. Cesare Pavese
history want grants
Everyone wants to be Cary Grant. Even I want to be Cary Grant. Cary Grant
history
When you think about it, history is made to be broken. That's the way we look at it. E. Hicks
history lists surprise
History is merely a list of surprises. It can only prepare us to be surprised yet again. Kurt Vonnegut
history
History! Read it and weep! Kurt Vonnegut
history disposition efficacy
But the power of instruction is seldom of much efficacy, except in those happy dispositions where it is almost superfluous. Edward Gibbon
hopes-and-fears seasons
Hope and fear cannot alter the seasons Chogyam Trungpa
hopes manage recreate trying
When you're trying to recreate habitat, you do it in hopes the amphibians can use it, and you have to manage it in hopes you keep the bullfrog from being successful. Don Arnold
hopes included light progress training view
Shane has resumed light training and hopes to progress this with a view to being included for the Ospreys match. Mark Davies
hopes separated support supporting
She hopes that she will get support from the BJP. I am supporting her because I don't think that I am separated from BJP. Uma Bharti
hopes identify system
We are going about this in hopes in will identify system problems. Paul Nelson
hopes military mind power type
One hopes that they'll never be able to use mind control weapons, because we're all done for if that happens. I don't want military people, or political people, to have that type of power over those of us who just get by from day to day. Joe Haldeman
hopes realize walk walking
My hopes right now are to be able to walk again, because you realize how important walking really is to you. Melissa Wilson
hopes newcastle
My hopes for Newcastle are the same as they were before Bath, Richard Hills
hopes public
If a lecturer, he wishes to be heard; if a writer, to be read. He always hopes for a public beyond that of the long-suffering wife. Samuel E. Morison
manipulation manipulate
I've never tried to manipulate my image. Alan Alda
management function greater
The smaller the function, the greater the management. C. Northcote Parkinson
man poetry
The poetry was the man, the man was the poetry. Brian Trehearne
manipulative
I'm not naturally manipulative. Benjamin Netanyahu
mankind historian dependence
What would become of history, had we not a dependence on the veracity of the historian, according to the experience, what we have had of mankind? David Hume
managers
I've been told I'm a good midcareer manager. Arne Glimcher
manners cowardice characteristics
Ever the characteristic manners of cowardice. Edward Everett
manhattan
Whenever I leave Manhattan, I get the bends! Ed Koch
management terrorism torture
Shamefully we now learn that Saddam's torture chambers reopened under new management, U.S. management. Edward Kennedy
models shifting
Our system is dynamic, always shifting gears. What I do is I build models to beat the market. Louis Navellier
model notion
We have no preset notion of how the model will look. Kim Polese
model
We want to make this a model for other communities in the future. Deborah Abbott
models modeling session
I have never been a professional model; I have had some modeling sessions. Alexandra Kosteniuk
models taller
I want my models to be bigger, stronger and taller than common mortals. I need superwomen and supermen. Thierry Mugler
model
My dream is to make Katihar a model district. I have no personal ambition. Tariq Anwar
model
I started to model because I thought I could use it as an excuse to others, like, 'Yeah, I'm tall because I'm a model.' Tao Okamoto
model regime
The coalition is a model that has no place in a presidential regime such as in Mexico. It fits in parliamentary models, but Mexico has a presidential regime. Enrique Pena Nieto
model people shows work
Shows don't reunite because television doesn't work that way. There's no profit model and people go off to do other work. Mitchell Hurwitz
parent religion indifferent
The universe, he observed, makes rather an indifferent parent, I am afraid. Charles Dickens
parent kind theater
My parents certainly didn't have anything to do with the theater. I'm some kind of accident. Alan Rickman
parent pious
My parents are deeply pious Hindus. Akhil Sharma
parenthood checks planned-parenthood
I never wrote a check to Planned Parenthood. Chris Christie
parent age pressure
My parents from a very young age raised my sister and I under a pressure to achieve. Theyre both attorneys. So good marks, getting through university, there was a huge emphasis and pressure to do well and keep going. David Schwimmer
parent projection
Your parents are your projection-nothing more. Byron Katie
parent musician
Both of my parents were musicians. Bryan White
parent wanted accountants
My parents wanted me to work in a bank or as an accountant. Bruno Tonioli
parents tap trying word
We are aggressively trying to get the word out to parents about how they can tap into this resource. John Whiting