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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
appearance contracts grooming
I did a lot of personal appearances because I was under contract to ABC. David Selby
appearance family gets girl instantly looks takes
I like a girl that takes pride in her appearance - looks are important to me, but it's also important she gets on with my friends and family. If my parents don't like a girl, then she's instantly a no-go. Luke Pasqualino
appear concept okay reason serious
The other reason is the concept of attitude. I didn't want to appear angry, but it's okay to appear serious or to not smile. Herbie Hancock
appearance asking context government players reform results testify
The other players did not testify before this committee, ... We are asking for these results in the context of Palmeiro's appearance before the Government Reform Committee. E. B. White
appear news positive
The positive news is we appear to be making progress, Dick Cheney
appear buy clear companies confused costs cut direction due economy employers expensive foreign fuel higher increased inflation job numbers picture prices seeing soar weaker year
The only clear picture we have from the job cut numbers this year is that employers appear to be confused about the direction this economy is taking, ... Companies are experiencing increased business, but they are also seeing their costs soar due to higher fuel prices, inflation in supplier prices and a weaker dollar, which makes it more expensive to buy foreign parts. John Challenger
appears appreciate chairman deeply democratic facts house letter members responding response specific written
We appreciate the chairman responding to us but we also find his response deeply disturbing. The letter appears to have been written without any investigation of the specific facts in this case. It also appears there was no consultation with the Democratic members of the House Administration Committee. Ellen Tauscher
appear applied beijing case court decided evaluation postponed review summon witnesses
We applied to summon more witnesses to appear in court and review the evaluation conclusions. So the Beijing No. 2 Intermediate People's Court has decided this case is postponed for one month. Mo Shaoping
appear default help helps maybe memory plan solve systems
We appear to use memory systems often in our default states. This may help us to plan and solve problems. Maybe it helps us be creative. But it may also have metabolic consequences. Randy Buckner
country easy walks
It is not easy to walk alone in the country without musing upon something. Charles Dickens
country men climate
In all countries where nature does the most, man does the least. Charles Caleb Colton
country travel home
Those who visit foreign nations, but associate only with their own country-men, change their climate, but not their customs. They see new meridians, but the same men; and with heads as empty as their pockets, return home with traveled bodies, but untravelled minds. Charles Caleb Colton
country sadness men
In great cities men are more callous both to the happiness and the misery of others, than in the country; for they are constantly in the habit of seeing both extremes. Charles Caleb Colton
country heart simple
As the grand discordant harmony of the celestial bodies may be explained by the simple principles of gravity and impulse, so also in that more wonderful and complicated microcosm, the heart of man, all the phenomena of morals are perhaps resolvable into one single principle, the pursuit of apparent good; for although customs universally vary, yet man in all climates and countries is essentially the same. Charles Caleb Colton
country self names
The most notorious swindler has not assumed so many names as self-love, nor is so much ashamed of his own. She calls herself patriotism, when at the same time she is rejoicing at just as much calamity to her native country as will introduce herself into power, and expel her rivals. Charles Caleb Colton
country mean hands
Old Marley was as dead as a doornail. Mind! I don't mean to say that, of my own knowledge, what there is particularly dead about a doornail. I might have been inclined, myself, to regard a coffin-nail as the deadest piece of ironmongery in the trade. But the wisdom of our ancestors is in the simile; and my unhallowed hands shall not disturb it, or the Country's done for. You will therefore permit me to repeat, emphatically, that Marley was as dead as a doornail. Charles Dickens
country night men
If its individual citizens, to a man, are to be believed, it always is depressed, and always is stagnated, and always is at an alarming crisis, and never was otherwise; though as a body, they are ready to make oath upon the Evangelists, at any hour of the day or night, that it is the most thriving and prosperous of all countries on the habitable globe. Charles Dickens
country character men
Rattle me out of bed early, set me going, give me as short a time as you like to bolt my meals in, and keep me at it. Keep me always at it, and I'll keep you always at it, you keep somebody else always at it. There you are with the Whole Duty of Man in a commercial country. Charles Dickens
degrees measuring productivity
Stop measuring days by degree of productivity and start experiencing them by degree of presence. Alan Watts
degrees biology
One of my degrees was a science degree in biology. Elizabeth Moon
degrees hysterical easy
The degree of notoriety I have is fine and easy. There's nothing hysterical about it. Bill Nighy
degrees punjabis marble
Marble flooring is to a Punjabi what a foreign degree is to a Tamilian Chetan Bhagat
degree depend economic hope partners trading whether wrenching
Whether those adjustments are wrenching will depend ... on the degree of economic flexibility that we and our trading partners maintain, and I hope enhance, in the years ahead, Alan Greenspan
degree fund seed
We're going to seed the clouds. To what degree and how we do it and how we fund it is yet to be determined. Herb Guenther
degrees bliss form
The highest form of bliss is living with a certain degree of folly Desiderius Erasmus
degrees done sitcom
I had done the sitcom thing to lesser and lesser degrees of success. David Alan Grier
degree detail difference exist machine molecular tiniest
The really big difference is that what you make with a molecular machine can be completely precise, down to the tiniest degree of detail that can exist in the world. K. Eric Drexler
held people supported war
The people who supported the war must be held accountable. Jonathan Tasini
held higher responsibility social standard
We have a social responsibility and we are held to a higher standard than other institutions, Jackie Robinson
held moving work
We have never held out or said that we are doing everything perfectly, and we have accomplished everything. We have said that there's more work to be done, but that we are moving forward. Dr. Fukino
held low market regard stocks
Fundamentally cheap stocks are often held in low regard by market participants. Something may be tainting their perception in investors' minds. Kenneth Fisher
held liked points taken
We would've liked to have taken those points and held on to them a little. Bill Kennedy
held meetings room sam since team time
We're in the room where Sam (Torrance) held all the team meetings in 2002, it's the first time I've been in here since then. Paul McGinley
held
I just feel like I have this gift that I've been given. It's like, 'Someone unwrap it! Here it is!' That drive can't be held down. Katy Perry
held kids sure
We want to make sure these kids aren't held up. Heidi Perlman
held publish
I think the next thing I publish will be for children, but I don't really want to be held to that because I also know what my next book for adults will be, and I really like that, too, so it depends. I've always had more than one thing going. J. K. Rowling
history who-we-are way
History is a guide to navigation in perilous times. History is who we are and why we are the way we are. David McCullough
history want done
No harm's done to history by making it something someone would want to read. David McCullough
history social shank
History is the shank of the social sciences. C. Wright Mills
history lafayette might
For women, history does not exist. Murasaki, Sappho, and Madame Lafayette might be their own contemporaries. Cesare Pavese
history want grants
Everyone wants to be Cary Grant. Even I want to be Cary Grant. Cary Grant
history
When you think about it, history is made to be broken. That's the way we look at it. E. Hicks
history lists surprise
History is merely a list of surprises. It can only prepare us to be surprised yet again. Kurt Vonnegut
history
History! Read it and weep! Kurt Vonnegut
history disposition efficacy
But the power of instruction is seldom of much efficacy, except in those happy dispositions where it is almost superfluous. Edward Gibbon
names errors mind
With respect to the authority of great names, it should be remembered that he alone deserves to have any weight and influence with posterity, who has shown himself superior to the particular and predominant error of his own times; who, like the peak of Teneriffe, has hailed the intellectual sun before its beams have reached the horizon of common minds. Charles Caleb Colton
names inheritance proud
The inheritance of a distinguished and noble name is a proud inheritance to him who lives worthily of it. Charles Caleb Colton
names rivers cry-the-beloved-country
Now God be thanked that the name of a hill is such music, that the name of a river can heal. Alan Paton
names evil done
When the persecution of an individual who has exposed an evil is pursued so ruthlessly and yet the evil itself is studiedly ignored, all of us know that there is something very wrong with the way that our society is conducting itself. And if we do not protest in the strongest terms about what is being done in our name, then we become complicit. Alan Moore
names aftermath bangs
Despite its name, the big bang theory is not really a theory of a bang at all. It is really only a theory of the aftermath of a bang. Alan Guth
names
Bullock by name, and Bullock by nature. Alan Bullock
names mind use
Only brand names register in the mind... What you should generally do is take a regular word and use it out of context to connote the primary attribute of your brand. Al Ries
names justice police
Any use of the names of Eric Garner and Michael Brown, in connection with any violence or killing of police, is reprehensible and against the pursuit of justice in both cases. Al Sharpton
names guy together
Jazz brought this sense of democracy where four guys come together and your name may be on the marquee, but in this moment, when you're the soloist, it's you, and we follow you. We follow you. Al Jarreau
public-trust
I have never, not once, violated my public trust. Alan Mollohan
public
Where there is muck to be raked, it must be raked,and the public must know of it, that it may mete out justice.... S. Hughes
publicity enough good-enough
If my work was good enough, I would never have to do publicity. David Duchovny
publicity
Americans understand better than the Europeans and the English that any publicity is good. Carl Andre
public-opinion found ministers
I know where there is more wisdom than is found in Napoleon, Voltaire, or all the ministers present and to come - in public opinion. Charles Maurice de Talleyrand
public
When times are tough, public employees should have to make the same sacrifices as everyone else. Robert Reich
public
Public employees should have the right to bargain for better wages and working conditions, just like all employees do. Robert Reich
public
My personal style and public style are very different. When I go out, I play dress up. Sharon Stone
publicity obituary
There's no bad publicity except an obituary. Brendan Behan
quiet hours peace-and-quiet
But I do like to have peace and quiet for a good hour. Bryan Ferry
quiet-voice people tree
Censorship is saying: 'I'm the one who says the last sentence. Whatever you say, the conclusion is mine.' But the internet is like a tree that is growing. The people will always have the last word - even if someone has a very weak, quiet voice. Such power will collapse because of a whisper. Ai Weiwei
quiet introvert minimalist
I am a minimalist. I like saying the most with the least. Bob Newhart
quiet knows
You cannot be quiet about things that you know. Ed Begley, Jr.
quiet-people thinking rude
Because I'm quiet, people think I'm really cold, or rude, or snobby. But I'm literally scared to talk to them. Dee Dee Ramone
quiet quiet-life
When it is possible, I choose to have a quiet life. Diego Della Valle
quiet enough virtuous
She lived, we'll say, A harmless life, she called a virtuous life, A quiet life, which was not life at all (But that she had not lived enough to know) Elizabeth Barrett Browning
quiet silent
There was a time when the music fell silent. Both within me and around me. Agnetha Faltskog
quiet habit trumpets
It's a good habit to trumpet your failures and be quiet about your successes. Charlie Munger
small-business enjoy taxes
The marginal tax rate for high income earners is going up. Small businesses are no longer enjoying some of the exemption from payroll tax. Now there will be carbon taxes. Chris Alexander
small-numbers community energy
Despite the international scientific community's consensus on climate change, a small number of critics continue to deny that climate change exists or that humans are causing it. Widely known as climate change "skeptics" or "deniers," these individuals are generally not climate scientists and do not debate the science with the climate scientists... David Suzuki
small-details details add
It takes 500 small details to add up to one favorable impression. Cary Grant
small-acts millions
A small act is worth a million thoughts. Ai Weiwei
smallness
I've not conducted my life in the service of smallness. Barry Diller
small-acts bless acts-of-service
Often small acts of service are all that is required to lift and bless another. Dieter F. Uchtdorf
small-objects hands eggs
There was a feeling, not sudden, but complete, as though I had been given a small object to hold unseen in my hands. Precious as opal, smooth as jade, weighty as a river stone, more fragile than a bird's egg. Infinitely still, live as the root of Creation. Not a gift, but a trust. Fiercely to cherish, softly to guard. The words spoke themselves and disappeared into the groined shadows of the roof. Diana Gabaldon
small-changes lasting-change healthy
It's the fact that no matter how bad it's gotten, the body wants to be healthy. The body wants to bounce back. When you do these changes, you do these small changes every single day, and you trust the process of what you're doing. You really do make lasting changes onto your body. Bob Harper
small stuff turned
When we were younger, you know, small stuff was small stuff. But we turned it into big stuff. It's just part of being young. Nikki Sixx
society disease want
Those who have resources within themselves, who can dare to live alone, want friends the least, but, at the same time, best know how to prize them the most. But no company is far preferable to bad, because we are more apt to catch the vices of others than their virtues, as disease is far more contagious than health. Charles Caleb Colton
society facts hints
Trivial facts are often the best hints to what is going on. John Roberts
society used states
Society soon grows used to any state of things which is imposed upon it without explanation. Edith Wharton
society cleaning neighborhood
In a neighborhood, as in life, a clean bandage is much, much better than a raw or festering wound. Ed Koch
society might ornaments
He might have proved a useful adjunct, if not an ornament to society. Charles Lamb
society alive intimacy
Society, dead or alive, can have no charm without intimacy and no intimacy without an interest in trifles. Arthur Balfour
society
Like its politicians and its war, society has the teenagers it deserves. J. B. Priestley
society
I don't think theatre has changed; it's society that has changed. Lee Hall
society might firsts
The day we learn to allow an ambulance to pass through in traffic, might be the first step towards being a truly responsible society. Boman Irani
wealthy wanted
I always wanted to be wealthy. I did. Carl Lewis
wealthy
Nothing is more intolerable than a wealthy woman. Juvenal
wealthy
I'm really calling for major jobs, because the wealthy are going create tremendous jobs. They're going to expand their companies. Donald Trump
wealthy
We don't want to be a place where you have to be wealthy to live here. George Twigg
wealthy
I think this is a very wealthy country. Lakpa Sherpa
wealthy
This is a very big drive, and this is not a wealthy area, Charles Potter
wealthy
I can see where they wouldn't want this to happen, but when you get up around $4,000 ... I don't have that kind of money. I never was and never will be a wealthy person. Fred Lawrence
wealthy
They were wealthy and there have to be more. Ann Thompson
wealthy avenues
We must devastate the avenues where the wealthy live Lucy Parsons
whose
I remember certain lines and whose they are. Warren Zevon
whose withhold
When you seek advice, do not withhold any facts from the person whose advice you seek. Abu Bakr
womanly
I feel very strongly that 'curves' are natural, womanly and real. Kate Winslet
woman
She was a woman very out of her time, Hilary Swank
woman
The most humiliating thing a woman can be is a coquette. Oriana Fallaci
woman women
Of all the plagues with which the world is cursed, / Of every ill, a woman is the worst. George Granville
woman women
It is not so far-fetched for a 63-year-old woman to be with an 18-year-old boy. Ian Gray
woman women
You're only as old as the woman you feel. Peter Stringfellow
woman
He said she was beautiful. And that he'd never been with a woman so beautiful. Traci Bingham
womanly dies
Shall there be womanly times? Or shall we die? Ian Mcewan
woman
I'm a woman of mystery. I can do anything but skinny. Ona Solomon
written
'Swimming Pool' was a very important moment for me because the character was written for me. Ludivine Sagnier
written
I've done episodic television and some other things that have been written by other people. Lisa Cholodenko
written
The average American doesn't realize how much of the laws are written by lobbyists. Eric Schmidt
written
I will say that a lot of songs that I've written are from my own personal experiences which are special to me. Victoria Justice
written
I've always written plays for the purpose of getting something out of my system. Wole Soyinka
written
I regret that I have not written more, shouted louder, and acted out my beliefs. F. Sionil Jose
written
I've been writing a lot more, I believe, because of the Internet. I've been posting stuff that I've written and I've just been writing. Errol Morris
written
I don't read books regularly, because I'm always writing them. I've written 30 books, thousands of pages. Ferran Adria
written
I've just always written songs in a style that appeal to me personally. Lyle Lovett