Leon Speroff
Leon Speroff
agreement cancer effect lack large major small tells therapy
With breast cancer and hormone replacement therapy, we have the opposite, ... We have lack of agreement, lack of uniformity, lack of consistency. That tells me that if hormone therapy has an effect on breast cancer, it has to be a small (one). If it were a major effect, a large effect, we would have agreement.
cancer decision difficult face growing number survivors whether
We have a growing number of breast-cancer survivors who face a very difficult decision about whether or not to use HRT,
art negative opposite positive reports respected state teams weeks
We have over 50 studies, and there is no clear-cut answer, ... We have positive studies. We have negative studies. I think the state of the art was beautifully illustrated in 1995 when we had reports from (two) respected teams of epidemiologists with opposite conclusions, two weeks apart.
against believe cancer causes heart lung oral protect protects smoking
We all believe that oral contraceptives protect against ovarian cancer, ... Most of us believe that estrogen protects against coronary heart disease. We all believe that smoking causes lung cancer.
believe says study
Why do I believe it? Because every study says the same thing,
available clinical data decision support until
Until data are available from randomized clinical trials, the patient's decision is the right decision -- support it.
absence wrong
In my opinion, in the absence of studies, in the absence of data, there is no right or wrong answer,