Jef Boeke
Jef Boeke
Jef D. Boeke is an American geneticist who is currently the founding director of The Institute for Systems Genetics at NYU Langone Medical Center. From 1986 to 2014 he was on the faculty of The Johns Hopkins University School of Medicine, where he was the founding director of the High ThroughputCenter. He is a member of the American Academy of Arts and Sciences as well as the National Academy of Sciences...
caused difficult diseases gene human multiple mutations
A lot of human diseases are caused by multiple gene mutations that are difficult to identify.
ability again along artificial chain copies critical cut designing easily engineer genes millions paste pieces process putting rapidly sites specific spots together using
To make use of artificial genes we need to make millions of copies of them for experiments using a process called polymerase chain reaction. By putting restriction sites into specific spots along the gene, we can cut it into bite-sized pieces that are easily duplicated millions of times. So the ability to cut and paste genes back together again is critical for designing genes to the right specifications, rapidly replicating them and putting them into vectors to genetically engineer cells.
ability again along artificial chain copies critical cut designing easily engineer genes millions paste pieces process putting rapidly sites specific spots together using
To make use of artificial genes, we need to make millions of copies of them for experiments using a process called polymerase chain reaction. By putting restriction sites into specific spots along the gene, we can cut it into bite-sized pieces that are easily duplicated millions of times. So the ability to cut and paste genes back together again is critical for designing genes to the right specifications, rapidly replicating them and putting them into vectors to genetically engineer cells.
cancer discovered genes help human less select targeted targets toxic versions
The interactions we discovered in yeast could also help researchers select the human versions of these genes suitable as targets for the development of new, more targeted and less toxic cancer therapies.
address gene programs separate steps synthetic
In the past, researchers had to use many different programs to address all the requirements of the separate steps of synthetic gene design.