Anthony Fauci
Anthony Fauci
Anthony Stephen "Tony" Fauciis an American immunologist who has made substantial contributions to HIV/AIDS research and other immunodeficiencies, both as a scientist and as the head of the National Institute of Allergy and Infectious Diseases...
NationalityAmerican
ProfessionScientist
Date of Birth24 December 1940
CountryUnited States of America
came fact hoped line percent response
We hoped to see a 75 percent response rate, but the fact it came in at 50 percent is not way out of line for our expectations.
both contain elements immune itself presenting recognizes response system ultimately
When you vaccinate someone, or when you get infected, the microbe is presenting itself to the immune system in a way that the immune system recognizes the important elements of the microbe and makes an immune response, both an antibody response and a cellular response, to ultimately contain the microbe.
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Historically, a live vaccine induces more potent, lasting and broader immune responses than a killed vaccine. The body is seeing the microbe in a way that is much more analogous to a real infection.
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If we could identify what that factor is -- and there's no guarantee we will, but if we can -- then one could direct your vaccine to elicit a response of that particular factor that is protecting them.
best body broader entire immune infection lasting mimic purpose responses seeing vaccine
The entire purpose of a vaccine is to mimic infection as best you can. Historically, a live vaccine induces more potent, lasting and broader immune responses than a killed vaccine. The body is seeing the microbe in a way that is much more analogous to a real infection.
along anthrax attack chain learned people vulnerable
What we learned from the mail-service anthrax attack of 2001 is that you really have to look at the vulnerable people along the chain of exposure.
available currently eliminate eradicate given virus
It does tell us is that given the currently available regimens that we have of anti-viral drugs that we are not going to eliminate or eradicate the virus from individuals,
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It is an ingenious mechanism that the virus uses by having this big burst of expansion and the cells respond,
course early
We now know that these reservoirs are established very early in the course of infection.
true
We have to see if it is true and if we can do anything about it,
alter blunt burst course early enormous initial prevent production virus
Vaccines, if they can blunt that initial, enormous burst of virus production early on, even if it doesn't prevent initial infection, may dramatically alter the course of infection,
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We have a vaccine we know can spur an immune response, albeit at very high doses. We're going in the right direction. The sobering news is we have a long way to go. So it's muted good news.
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The AIDS epidemic is one of the greatest challenges to our society today. It is a fight that we cannot afford to lose.
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You have to prepare for the worst, but it's entirely conceivable that we could have a moderate one. You have to prepare for a horrendous problem, but the general public shouldn't assume that we're going to see the worst case.