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advance benefit cells directly five goal huge illnesses known patients potential progress recently results stem towards ultimate using variety widely
The potential of stem cells has been widely known for many years, but it is only recently we have started to make progress towards the ultimate goal of using them in patients. These results show it may be as little as five years before this advance can be used to directly benefit patients for a huge variety of illnesses and injuries. Anne Bishop
advance believe congress convince core perception value voters work
The perception by the core value voters is that Congress has not done enough to advance their core issues. We believe they have been at work, but there is more work to be done to convince their constituencies. Tony Perkins
advance appreciate gotten help support thank
We appreciate all the help we have gotten so far. Without the support of the community, we wouldn't have the school. We want to thank everyone in advance for everything done. Jo Brown
advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advance clinical company eventual experience extensive manage partner pleased rapidly required technology
We are pleased to partner with a company with the extensive cardiovascular experience required to rapidly advance our technology through the clinical development and regulatory process, and manage the eventual manufacturing and commercialization. Robert Harris
advances agreement businesses company enter exit focus growth mature pleased reputation sale strategy
We are pleased to enter into the agreement with Nekoosa Coated Products, a company with a well-earned reputation in the industry. Also, the sale advances Nashua's strategy to exit non-strategic and mature businesses and focus on growth opportunities. Andrew Albert
advance conference easy fall girls ncaa rattled season straight stuck tournament wins
We started the season 5-5 and it would have been easy to fall off. The girls stuck with it, and we rattled off 14 straight wins at one point. Getting back to the conference championship and making the NCAA tournament is pretty important to our players. Hopefully, we will advance and do well. Dee Bell
advances believe imminent item law near pricing recent require
We believe that recent and imminent technological advances will require a modernization of the item pricing law in the near future. John Simley
advances deaths direct everyday seeing
We are seeing advances everyday and deaths are decreasing. It is a direct correlation. Jan Ulmer
clinical goal health improving information outcomes patient placing pleased point support
We are pleased with this partnership and how it will support our goal of improving the outcomes of patient care. We are placing more of our world-class, clinical information where health practitioners need it to support their clinical decisions--directly at the point of care. Brian Nairn
clinical goes nursing responsibility shortage specific standard stopping student taking trained
We want every student trained to a specific standard before he or she ever goes into a clinical area. We're taking as much responsibility for stopping the nursing shortage as we can. S. Walker
clinical foundation future scientific solid
We're getting a solid scientific and clinical foundation for the institute's future work. Michael Goldberg
clinical
We know where we went wrong. We weren't clinical enough. Mike Catt
clinical might
There are two important observations that might have clinical relevance. Deborah Muoio
clinical founders infinitely looking scientific symptoms
Carl von Rokitansky is one of the founders of scientific medicine and systematized it, looking at what the clinical symptoms mean. The medicine we practice today, which is infinitely more sophisticated, is Rokitansky's medicine. Eric Kandel
clinical course died illness laboratory probable prove similar symptoms test
She had similar symptoms and the clinical course of her illness was the same. So it would be very probable that she died of H5N1, but right now we don't have the laboratory test to prove that. Maria Cheng
clinical front ruthless
We need to become more ruthless and clinical in front of goal. Gary Neville
clinical create priorities problems recorded
Many clinical priorities aren't recorded and some targets, like A&E and GP bookings, create more problems than they solve. Andrew Lansley
conducting mine people
The people who were inspecting the mine will not be the people conducting the investigation. Ellen Smith
conduct patient quality related
unprofessional conduct not related to the quality of patient care. Paul Jensen
conduct county either election join position share spend
We're in a position where we either spend well over $100,000 to conduct our own election or we join with the county and share in the election cost. Leon Cubillas
conduct criminal means
We're making criminal enterprises look to different means to conduct their business. We see it as a desperation move. Doug Mosier
conduct debate invite respect sponsors welcome
We respect the prerogative of debate organizers to conduct the debate sponsors as they see fit. We would welcome Russ Potts if the organizers wanted to invite him. B. F. Skinner
conduct explain family fortunate members rather
We're so fortunate that we can now conduct an investigation into how this thing got going rather than have to explain to the victims' family members why something like this could have happened. I don't know what we would have done if something like this had really happened. Sheriff Norman
conductors god orchestra rolling seen stop stopped technique time
So many times, I've seen conductors that, every time they have a thought, they stop the orchestra and say it, and I can see the orchestra rolling their eyes and saying, 'Oh, God, he stopped again.' So there's a technique to rehearsing. Joshua Bell
conduct example life personal poor powerful
Should a person who's the most powerful person in the world conduct his personal life in such a way that would be a poor example to our children? Ross Perot
conduct create message sends serious wrong
Short-term suspensions for egregious conduct create a serious problem. It sends the wrong message to officers. Howard Friedman
critical focus stretch winning
We want to see if we can get that done, ... So our focus is winning the first one. This is a very critical two-week stretch for us. Tony Dungy
critical stage
We are at a very critical stage in our negotiations, John Broughton
critical people time
We're in that critical time that people can be rescued, ... If we don't get out thereto and do it now, then they're going to die. Pat Sullivan
critical-spirit habit critical
Make it your habit not to be critical about small things. Edward Everett Hale
critical literally room
We have no room literally to spare. Every game, every day is critical to us. Dave Wannstedt
critical injuries minor multiple serious
We have multiple critical injuries and multiple serious injuries and some minor injuries, Willie Williams
critical department fatal suffers whenever
Whenever the department suffers a fatal fire, we take a constructive, critical look at the event. Thomas Galvin
critical our-lives anything-is-possible
Health is the most critical thing in our life. With your health anything is possible, without it you can't do anything. Bill Walton
critical people reporters time truth war whining
While many people think that we as reporters are whining and that this is a time of war, we are really the conveyors of truth in a very critical time and people need to know that truth. Judd Rose
deliver firmness gained message openness perhaps prime state stood together
The one who has perhaps gained the most is the prime minister, who stood for the state and managed to deliver a message of firmness together with a message of openness to society. Dominique Moisi
deliver medium power
The power is there. It's more than just a fad. It's a new medium to deliver content. Garth Tuck
delivered period proud public quarter reporting strong
We are proud of the strong quarter that we have delivered in our first reporting period as a public company. Paul House
delivery facility millions modern paved spent treatment water
We spent millions installing a modern water delivery system, sewage treatment facility and paved roads. Kip Petersen
delivered fifth game god kept miracle race seed somehow
We approached this as a must-win game because it solidifies our fifth seed in districts, and kept us in the second-half race if somehow God delivered some miracle and Halifax lost. Mike Reed
deliver doubt splendid
We have no doubt that BOCOG will deliver in a splendid way. Jacques Rogge
delivered food
Was the person you delivered (food) to Mr. McVeigh?, Stephen Jones
deliver earnings excited growth prepared remain
We remain prepared to deliver double-digit earnings growth in 2001, but most importantly we're excited about how well GE is positioned for the future, Jeffrey Immelt
delivered great history money places promotion spending
We're spending more money on this than any other promotion in UPN history. They've delivered to us a great pilot, and we want to get this out in as many places as we can. George Schweitzer
diabetes education emphasize measure perception portion standard visual
When I do weight-loss education or diabetes education I really emphasize portion size. Measure things out so they get a visual perception of what a standard portion should look like. Jenny Gardner
diabetes forefront general goes good issue nfl obesity people stunt time
When you're still playing, you're lifting, you're conditioning and you're still young. You can stunt the onset of some of these disabilities. But as time goes on, particularly for African-American players, things like diabetes become more pronounced. Obesity is an issue for people in general ... and the NFL can take the forefront on this by stressing good nutrition. Angelo Wright
diabetes family feeling history type
I was feeling great. So I don't even know how long I had had type 2 diabetes. I have no family history of diabetes whatsoever. Della Reese
diabetes disease gateway heart host obesity
Obesity is a gateway to heart disease, diabetes and a host of other diseases. Parris Glendening
diabetes doubling found type
From 2002 to 2005, we found a doubling of type 2 diabetes medications. Emily Cox
diabetes fact higher known minorities rate
it is a known fact that African-Americans and other minorities have a higher rate of diabetes and other diseases. Wendy Moore
diabetes diagnosed
I was diagnosed with diabetes about 20 years ago. Jim Fox
diabetes example great manage patient
Diabetes is a great example whereby, giving the patient the tools, you can manage yourself very well. Clayton Christensen
diabetes disease insulin manage patients treat until
Until today, patients with diabetes who need insulin to manage their disease has only one way to treat their condition. Steven Galson
effective-listening listening
Listening is a positive act: you have to put yourself out to do it. David Hockney
effective forces gravity known objects stuff
We account for one-sixth of the forces of gravity we see in the universe. There is no known objects accounting for most of the effective gravity in the universe. Something is making stuff move that is not anything we have ever touched. Neil deGrasse Tyson
effective exercise group major patients performed reducing seems showing standard studies symptoms
What the studies are showing is that exercise, at least when performed in a group setting, seems to be at least as effective as standard antidepressant medications in reducing symptoms in patients with major depression, James Blumenthal
effectiveness too-much loses
If you do too much it's going to lose its effectiveness. Bob Ross
effective tries ultimately
I think that ultimately any effective drama or tragedy tries to put you as much as it can into the protagonist's shoes. Nicholas Jarecki
effective front happy red tom
Tom Werner said this is a happy day for the Red Sox, and I agree. We?re a stronger, more effective and bolder front office. Larry Lucchino
effective family loved members returning saw talking veterans
What's so effective is the messengers. The returning veterans are talking about what they saw in Iraq. The family members are talking about their loved ones. Stuart Roy
effective marketing tool
We feel that subscriptions will be a very effective marketing tool for the lottery. Chuck Keller
effective flu hoping immune infection local preventing response sort virus
We're hoping that this sort of local immune response is going to be more effective at preventing infection with the flu virus than the kind of immune response you get with a flu shot. John Treanor
efficient federal future loans match money partly perkins program recycled resources schools students ways
The Perkins program is one of the most efficient ways to use federal resources -- schools partly match federal capital, and all the money is recycled into loans for future generations. Students need Perkins more than ever. Harrison Wadsworth
efficient members prompt proud team
We are proud of our team members who, in a prompt and efficient manner, extinguished the smoke. Kathy Shepard
efficient exploiting
Basically, I want to make all of humanity more efficient by exploiting the human cycles that get wasted. Luis von Ahn
efficient government whenever
Whenever you have an efficient government you have a dictatorship. Harry S Truman
efficient suddenly
When you're used to seeing someone being coldly efficient on court and suddenly they go on stage and into your world - it's fascinating. Adrian Smith
efficient existing forms
We must continue research into new forms of energy and into more efficient use of existing energy sources. Mac Thornberry
efficient playing tired
When we get the ball, we're not as efficient because we're tired and often take the first shot. We're playing into our opponents' hands. Jim Bolla
efficient hang
We're going to have to play very efficient and mistake-free to be able to hang in there with those guys. Michael Robinson
efficient extremely five four output phenomenal tremendous
We're extremely efficient and we do tremendous things in that shop. We have phenomenal through-put. The output would make it look like it's four or five times its size. Sean Farnel
enabling
The magic of GoPro is that we are enabling the world to communicate in this new way, to express themselves in a new way, and it's snowballing. Nick Woodman
enabling facts needs
Business is just about enabling human beings, nothing more, nothing less. Businesses need to recognize this fundamental fact. Bruce Dickinson
enabling identify improve individual problem problems reporting resolution root users
We use it for monitoring individual applications, enabling us to improve problem resolution for users who are reporting problems and efficiently identify the root cause. Rich Ackermann
enabling want excitement
He felt a spasm of excitement because he knew instinctively who it was, or at least knew who it was he wanted it to be, and once you know what it is you want to be true, instinct is a very useful device for enabling you to know that it is. Douglas Adams
enabling leadership liberal party renewal seek
While I did not seek it, I now see the need for that kind of enabling leadership in the renewal of the Liberal Party of Canada. Gerard Kennedy
enabling love people
We all do things for people we love and that's OK. But if you're doing it consistently and all the time, you're enabling them not to be responsible. Ron Miles
enabling multiple opportunity providers service tremendous
Enabling multiple service providers to be able to interoperate, we think, is a tremendous opportunity for the industry. Brian Arbogast
enabling exceed profit quarter revenue stellar year
This has been a stellar quarter and year for Scholastic, enabling us to exceed our revenue and profit goals. Richard Robinson
enabling humans nuclear rocket technology
In my opinion, a nuclear rocket is an enabling technology for humans to go to Mars. Steve Howe
innovative valuable
Diversity is America's most valuable resource. It is what makes us the most innovative nation on Earth. Nick Hanauer
innovative san spread
I wish the city of San Francisco, bastion of liberalism, were more innovative when it comes to how to spread the wealth. Leila Janah
innovative knew music performed radically
Charles Ives was writing radically innovative music, but nobody performed it, and nobody knew about it. Terry Teachout
innovative sell
At Uniqlo, we're thinking ahead. We're thinking about how to create new, innovative products... and sell that to everyone. Tadashi Yanai
innovative recent represents
E-mail represents one of the most innovative technologies of recent years. Renzo Rosso
innovative offensive pick scheme tough
They have an innovative offensive scheme that is tough to defend, ... Defensively, they have some tough blitzes for us to pick up. Jack Bicknell
innovative model national program unique
This is a unique program and a national model for being a very innovative program. Michael Palmer
innovative islands providing public quality service signed
If you had not signed it, the public would know Innovative finances. The PSC, to some extent, is responsible for Innovative not providing quality service that Virgin Islands residents deserve. Sen. Hill
innovative priority top
It's top priority for us to be an innovative company, Steve Ballmer
living realized vibrant
I'd be like, 'You're a young, vibrant woman. Where are you?' I realized that I had been living in denial. Lorraine Bracco
living love peace time
I'm not an idealist. I know we're not going to be living in a world that's peace and love all the time. But we can live in a world where we kill each other a lot less. Michael Franti
living-right television film
I was about 26 or 27 and it was imperative that I make a living right away and it's hard to make a living on stage, so I started in television and film. David Duchovny
living-my-life clock touring
In general, I usually don't really go by or live my life by a clock, and outside of touring, I don't really ask anyone else to. It's not out of lack of respect for anyone or intentional. Axl Rose
living national reducing security survive throughout
Throughout history, when our national security has been threatened, we have responded by reducing liberties, ... we ask: We not only want to survive, but survive living under what conditions? Carol Lewis
living specific
When they were casting, Denis was very specific that he didn't want any actors from L.A. and I was living in L.A. at the time. Andrea Roth
living true wait
I'm so happy after such a long struggle to be living my true self. Welcome to the world, Caitlyn. Can't wait for you to get to know her/me. Caitlyn Jenner
living people principal rooms york
The principal artists' rooms are so big that in New York 12 people would be living in them, Peter Russell
living separated
What I did for a living for so many years separated who I was from what I did. Christy Turlington
management function greater
The smaller the function, the greater the management. C. Northcote Parkinson
management terrorism torture
Shamefully we now learn that Saddam's torture chambers reopened under new management, U.S. management. Edward Kennedy
management labor position
I will not be in the position of having management dictated to by labor. Charles M. Schwab
management son
Unfortunately, my son is not on the management team. Guy Dolle
management sole folly
Anger and folly walk cheek by sole. Benjamin Franklin
management employee knows
Your employees know each other better than they know you. Ben Horowitz
management behavior profit
Shareholders have the right and obligation to set the parameters of corporate behavior within which management pursues profit. Eliot Spitzer
management reason revision sales sony targets
So far, Sony management has no reason to make any revision in sales targets for the PlayStation, Nobuyuki Idei
management respond structure terms
This streamlines the management structure in terms of the way we respond to our owners. Mark Siegel
millions
I want to sell out arenas and sell millions of records. Katy Perry
millions
Let's just say it would be in the millions of dollars, F. Stone
millions pair restore surgery
A simple, well-proven surgery can restore sight to millions, and something even simpler, a pair of glasses, can make millions more see. Thulasiraj Ravilla
millions rainy sunday themselves
Millions long for immortality who do not know what to do with themselves on a rainy Sunday afternoon. Susan Ertz
millions people reason unified vote younger
So many millions of people don't feel like their vote has any meaning. There is no reason why younger people can't be a unified force. Mike Burkett
millions moment moments patient worthwhile
Not only will this make you treat each moment more preciously, but you will be more patient with yourself and with others, recognizing that there are millions of moments on the path to any worthwhile achievement. Menachem Mendel Schneerson
millions
If it's accessible by hundreds of millions of people, then it's as mainstream as it gets. Warren Ellis
millions politics
I'm in politics to make the lives of millions of Indians better. Nandan Nilekani
millions people somebody
I'm not sure who has the right to say that you have better taste than somebody else, because essentially what you're doing is calling millions of people morons. Simon Cowell
people may medical
It is astonishing how much more anxious people are to lengthen life than to improve it; and as misers often lose large sums of money in attempting to make more, so do hypochondriacs squander large sums of time in search of nostrums by which they vainly hope they may get more time to squander. Charles Caleb Colton
people solitude multitudes
A multitude of people and yet solitude. Charles Dickens
people governing whole
My faith in the people governing is, on the whole, infinitesimal; my faith in the people governed is, on the whole, illimitable. Charles Dickens
people words-of-wisdom selfishness
Others had been a little wild, which was not to be wondered at, and not very blamable; but, he had made a lamentation and uproar which it was dangerous for the people to hear, as there is always contagion in weakness and selfishness. Charles Dickens
people words-of-wisdom want
Mrs. Boffin and me, ma'am, are plain people, and we don't want to pretend to anything, nor yet to go round and round at anything because there's always a straight way to everything. Charles Dickens
people next cleanliness
Cleanliness is next to Godliness, and some people do the same by their religion. Charles Dickens
people scary alive
I have heard it said that as we keep our birthdays when we are alive, so the ghosts of dead people, who are not easy in their graves, keep the day they died upon. Charles Dickens
people enemy
Some people are nobody's enemies but their own Charles Dickens
people romance wonder-woman
Superman/Wonder Woman, people expected, I guess, a lot of romance, or maybe something that wasnt emotionally deep. Who knows? Charles Soule
proven team top
We know we can play with any team in the league. We've proven it before, and when we play hard, we play desperate, we're one of the top clubs, too. Jozef Stumpel
proven steal
She has proven she can probably steal on anybody. Ron Cosner
proven step taken whether
We need to look in those jurisdictions that have taken that step (to see) whether it's proven to be effective. George Smitherman
proven strong tackle themselves
No one has proven themselves strong enough to tackle it. Danielle Brian
proven question schedule schools
If other schools question why they didn't make it and we did, they should schedule differently. We've proven we belong. Jose Fernandez
proven step took
I don't know that we've proven anything yet. I think we took a step in the right direction. Jason Taylor
proven
He has made a point. he has proven what he can do. Travis Ramsey
proven safe soon
To be safe and soon we have to go with proven methods. Doug Young
proven
On 'Scandal,' they've proven that they're not scared of shocking the audience. Betsy Beers
research copying stealing
Copying one person is stealing. Copying ten is research. Chet Atkins
research just-being producers
But I'm a historian. I wasn't interested in just being a producer, I was interested in doing research and presenting that research to a general public Bernice Johnson Reagon
research fields modern
Never before in the history of the modern research university have entire departments and fields been devoted to purely ideological pursuits. David Horowitz
research sociopath psychopath
I'm a high-functioning sociopath, do your research. Benedict Cumberbatch
research
I don't research anything. Derek Bailey
research can-do
Do not do anything that anyone else can do readily. Edwin Land
research conducting finished
One must stop conducting research before one has finished. Otherwise, one will never stop and never finish. Barbara Tuchman
research sociopath psychopath
I'm not a psychopath, I'm a fully functioning sociopath. Do your research. Arthur Conan Doyle
research world body
I shall not cease learning while I live, nor when I arrive in the spirit-world… and when I again receive my body, I shall …still continue my researches Brigham Young
sponsors
We couldn't do what we do without our sponsors. I can't say enough how important our sponsors play into this. Howard Corcoran
sponsors
We want to give as much as we can back to our sponsors and benefactors, David Harris
technology hands people
Technology is destructive only in the hands of people who do not realize that they are one and the same process as the universe. Alan Watts
technology civilization goal
...the materialism of modern civilization is paradoxically founded on a hatred of materiality, a goal-oriented desire to obliterate all natural limits through technology, imposing an abstract grid over nature. Alan Watts
technology fit lifestyle
The success of SYNC is another proof point that we are doing just that. We will continue to innovate and expand the capability of SYNC by integrating even more new technologies that fit our customers’ lifestyles. Alan Mulally
technology matter watches
It doesn't matter what the technology is - no one will watch a Peter Greenaway film anyway. Alan Parker
technology fields needs
The computing field is always in need of new cliches. Alan Perlis
technology thinking people
I think it is inevitable that people program poorly. Training will not substantially help matters. We have to learn to live with it. Alan Perlis
technology bird worms
In software systems it is often the early bird that makes the worm. Alan Perlis
technology two benefits
Technology is always a two-edged sword. It will bring in many benefits, but also many disasters. Alan Moore
technology amish kind
I'm remote from most technology to the point that I'm kind of Amish. Alan Moore
thrilled vote won
thrilled if I won by one vote or more. Michael R. Bloomberg
thrilled
She's not real thrilled about me being away so long, but she's very understanding. Frank Nelson
thrilled
We had no idea it was still there. We were thrilled to find it. Roz Foster
thrilled vindicated
Ms. Rowling is thrilled to have been vindicated so clearly, Christopher Little
thrilled
I am thrilled with the results. I am thrilled he is going home. Scott Coffey
thrilled
I am thrilled for her. It's her dream. Carolyn Clark
thrilled
Bart is just thrilled to come back home. Harold Lewis
thrilled traders
I can tell you traders aren't thrilled by that idea. Tom Kloza
thrilled
I'm thrilled at the moment because our audiences, you know, they... the demographic is 50% male. Graeme Murphy
trials hardship response
It is not the trials in your life that develop or destroy you, but rather your response to those hardships. Charles Stanley
trials great-faith
Great faith must have great trials. Charles Spurgeon
trials surreal whole
The whole trial seemed surreal. Bernhard Goetz
trials matter criminals
A trial without witnesses, when it involves a criminal accusation, a criminal matter, is not a true trial. Bill McCollum
trial
let's have a trial and get it over with Patsy Ramsey
trials lord evidence
Trials are not consequences of your disobedience, they are evidence that the Lord feels you are prepared to grow more. Richard G. Scott
trials guilty
I watched the entire O.J. Simpson trial, and he was guilty. Connie Willis
trials failing bigs
I'm really concerned that too-big-to-fail has become too-big-for-trial. Elizabeth Warren
trials politics would-be
[Alan] Dershowitz has also offered to defend Osama bin Laden in court, saying it would be an act of high patriotism. It's kind of too bad there isn't going to be a trial. Having Dershowitz defend him could be Osama's only shot at not being the least popular person in the courtroom. Ann Coulter
work quality may
Although profoundly "inconsequential," the Zen experience has consequences in the sense that it may be applied in any direction, to any conceivable human activity, and that wherever it is so applied it lends an unmistakable quality to the work. Alan Watts
work apology giving
Give a civil servant a good case and he'll wreck it with clichés, bad punctuation, double negatives, and convoluted apology. Alan Clark
work mean doing-nothing
If I am doing nothing, I like to be doing nothing to some purpose. That is what leisure means. Alan Bennett
work sleep thinking
A gentleman ... sleeps at his work. That's what work's for. Why do you think they have the SILENCE notices in the library? So as not to disturb me in my little nook behind the biography shelves. Alan Ayckbourn
work play able
You've got to get good habits of working hard so that when that play comes up during the regular season that you're able to complete it and do it the right way. Al Kaline
work people kind
Japanese people tend to be much better adjusted to the notion of work, any kind of work, as honorable. Akio Morita
workout training cardio
I do a dance-based cardio workout infused with circuit training, and emphasizing strength and alignment. Chloe Sevigny
work-out effort feels
If I put forth a legitimate effort, then I feel like, if that doesn't work out, that's all I can do. Dave Chappelle
work-out levels mail
I always take a relationship to the next level. If that works out, I take it to the next level after that, until I finally reach that level when it becomes absolutely necessary for me to leave. Dave Chappelle