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advanced anticipate approval attention believe candidates compound continue deficit develop disorder fda filing future half lead looking performance pipeline plan pleased positions products progress quarter receiving research second together treatment year
We are pleased with our performance in 2005. The year was highlighted by the filing of the new drug application on NRP104, our lead compound under development, for the treatment of Attention Deficit Hyperactivity Disorder in pediatric populations. We believe that this advancement together with the progress on our other pipeline products positions us well for future growth. Looking forward, we anticipate receiving approval from the FDA on NRP104 in the second half of 2006 and making IND filings on NRP409 and NRP388, the two most advanced candidates in our preclinical pipeline, by the end of the second quarter of 2006. In addition, we plan to continue to develop NRP290, our second most advanced compound, and other drug products in our research pipeline. Krish Krishnan
advanced base broad continuing economics formal gain knowledge latter political reasonable science self skills symbolic together
By a combination of formal training and self study, the latter continuing systematically well into the 1940s, I was able to gain a broad base of knowledge in economics and political science, together with reasonable skills in advanced mathematics, symbolic logic, and mathematical statistics. Herbert A. Simon
advanced aggressive business companies corporate documents manage print providing realized since site tool web
We've always had an aggressive e-commerce strategy. Since our first Web site in 1994, we realized a Web site was more than just a corporate brochure. It had to be an advanced business tool providing everything companies need to design, print and manage their documents online. Dan Beck
advanced affordable based continue create full hosting needs offer product provides recognize satisfy solutions strive technology tools web
Web hosting was the first product in Affinity's portfolio, and it's still a very important part of our business; that's why we continue to strive to create solutions based on the most advanced hosting technology at an affordable price. However, we recognize the need to offer much more than just hosting to satisfy the needs of today's developer, which is why Gate.com also provides a full suite of advanced tools and web services. Jim Collins
advanced body dave destined early given later pay price running season sports strong talk training understanding workouts
What makes Dave so strong is his understanding of training and willingness to pay the price He has given up the other sports and focuses on running now. It's a little too early to talk about what he's destined to do. Later on this season we'll have a better idea. He's doing some advanced workouts and we will have to see how his body reacts. Ed Pancoast
advanced along approach architecture balanced business core customer data delivered earnings geographic key order per pleased proves results revenue second share solid strategy strong technology terms video
We're pleased with the solid revenue and earnings per share results Cisco delivered during its second quarter, but also especially pleased with our strong order momentum. This proves our strategy is working in terms of the convergence of voice, video and data along with our balanced approach to our customer segments, core and advanced technologies, business and technology architecture and key geographic theaters. John Chambers
advanced highly motivated
We're a well-trained organization, highly disciplined and highly motivated .. very technologically advanced here, Peter Ryan
advanced began people popular understand
Over the years, I began to understand that there were a lot of people out there reading physics in popular literature that they could not understand - not because it was too advanced, but because it wasn't advanced enough. Leonard Susskind
advanced pushed rate sales success terms
With these advanced capabilities, we see our success rate in terms of new and follow-up sales being pushed through the roof. Nigel Kelly
based behalf business customers decisions field includes line operating personnel regional responsibility restaurant ultimately
We want the line -- which for McDonald's includes our divisional and regional staffs, owner/operators and restaurant personnel -- to make decisions on behalf of customers based on field operating needs. The line ultimately has responsibility and accountability for our business success, Jack Greenberg
based historical issues number possible recently represent time
The possible pressurization issues that we've had recently do represent an above-average number for this time period, based on historical averages. Amanda Tobin
based brings coast critical guard happy helicopter remains reminder took
We are always so happy to see them. It is such a reminder of what the US Coast Guard brings to our community. It's also a reminder of what it took to get the helicopter based here and how critical it is that it remains here. Ginny Goblirsch
based benefits business count customers extract help honor market measure pleased recognized research shipments simply tries trust value
We value this honor more than designations based on research that simply tries to count shipments and measure market share. Our customers trust Zebra to help them extract the business benefits from RFID technology, and we are pleased that ABI has recognized our commitment. Bob Cornick
based believe credible evidence trial
We believe that these convictions are based on evidence that isn't credible and a trial that isn't fair, Adam Ereli
based open plan
We still plan to have the appraisal done and try to keep discussions open with them and at the appropriate time, based on the appraisal, try to initiate, once again, negotiations. Mike Clarke
based bush media move period tend time wisdom
We're in a period of time that there is a conventional wisdom that Bush is on the ropes. I think, based on my experience, that the media tend to move in lockstep as conventional wisdom on a story develops. Frank Newport
based jury
We're in a frenetic short-covering based rally. The jury is still out about how long this is going to last. Bernie Schaeffer
based issue items labor lies softer
Where the crux of the issue lies is that (certain) departments are so heavily based on labor force. There is more to it at the library, there's a little more flexibility about other softer items where you are just able to cut. Brent Trout
cleaned lead reason
We want to see it cleaned up. There?s no reason to have lead on the ground. Jim Rice
clean played raise
We've already played this gimmick, ... We want to play clean so we don't even raise the ceiling. Edmund Daukoru
clean couple cursed definitely hill impressed inspired might music
Lauryn Hill might have cursed a couple of times in her music, and Missy Elliot definitely just doesn't care. I'm really more inspired by their creativity more so than just the cursing. I'm really impressed by clean music. Lil Mama
clean resorts shock
You do a clean show and it's over and the audience have enjoyed themselves and you've enjoyed yourself, and you haven't had to resort to shock. Bob Newhart
cleanliness clean
I'm clean, I've always been clean. Barry Bonds
clean-underwear coffins literature
From the cradle to the coffin underwear comes first. Bertolt Brecht
clean
My stand-up act is very clean. Carol Leifer
cleaned
We have to get all that cleaned out. Martin Lee
clean notes
It's just music. It's playing clean and looking for the pretty notes. Charlie Parker
coalition exists forces
the possibility for condition-based reductions of coalition forces still exists for 2006. George Casey
coalition contents contract dealing pleased
We are pleased with the contents of the coalition contract and especially with that part dealing with the economy, Miroljub Labus
coalition commitment cross emergency encourage entire greater help information integral leader leaders life members month move national pleased prepare red saving spread state toward work
We are pleased to have the American Red Cross, which has long been a leader in emergency preparedness and response, co-sponsor National Preparedness Month 2005, ... The commitment of the American Red Cross and the members of National Preparedness Month Coalition are integral as we work to encourage all Americans to prepare for emergencies. As leaders in their communities, these organizations will help spread life saving information and move the entire nation toward a greater state of preparedness. Michael Chertoff
coalition details dictated exactly financial form government markets message worked
There are some details that need to be worked out (in determining) exactly what form of coalition government we're going to get. But essentially, the message for financial markets is 'yes -- reform,' but it's not going to be dictated by the conservative LDP. Jesper Koll
coal-miners underestimate economic
All too often miners, and indeed other trade unionists, underestimate the economic strength they have. Arthur Scargill
coal consider expand gas generating good increasing nuclear option power volatility
With the increasing volatility in the gas and coal markets, it makes good sense to consider nuclear power as an option to expand our generating fleet. Jeff Wallace
coalition conversation education hoping payment position reasonable taken
We're hoping that's where the conversation starts, because the Education Coalition has already taken the position that we'd like to see a sizeable down payment being made, then a reasonable payback over time. Scott Plotkin
coal coming dog opening operators price quick trying
With the price of coal so high, you have operators coming out of the woodwork, trying to get into any seam of coal they can to make a quick buck, opening up a lot of little dog holes. Tony Oppegard
coal electricity peak rail season situation summer
With the peak summer season for electricity approaching and rail deliveries of coal still not where we would like them to be, we are monitoring this situation carefully. Jim Owens
conversion entire newsroom totally
What's new is that entire newsrooms that once were one thing are totally different. The conversion of the traditional newsroom to the VJ newsroom is different. Al Tompkins
conversion far roman
In the Roman commonwealth, even on the conversion of the monarchy into a republic, the old was as far as possible retained. Theodor Mommsen
conversion higher rate series
Obviously, it is a series we want to win. If we have a higher conversion rate than we had on Sunday, that should not be a problem. P. Herbert
conversion easy plan relatively
The conversion was relatively easy to plan and accomplish. Winslow Goins
conversion ethanol limited problem proving supplies
The conversion is proving to be difficult. The U.S. has a problem with ethanol supplies because they are limited right now. Tetsu Emori
conversion generation models next older seeing stop super
What you're seeing now is conversion of older models to new prototypes. These are the next generation of Super Stop & Shops. The renovations will give a whole new look to the store. Robert Keane
conversion hard items pet pick target
Historically, we know that if we just pick top-selling items and e-mail them to people, conversion isn't that great. It's very hard to target in the pet space. You have to know a lot about that consumer. John Lazarchic
conversion cut deep effort gave oil rhetoric share
If it's not rhetoric it's an effort to recapture the share of the oil cut that they gave away to deep conversion refiners, Antoine Halff
conversion defense plays stepped
The defense stepped up. The two-point conversion and the interception, those are things that make memories. Those are the plays you live for. Ryan Jensen
direction february four industry lincoln mercury moving pleased program similar since
We are pleased to see the industry moving in this direction. Just to give you a little history, we launched a similar program enhancement four years ago. Ford, Lincoln and Mercury CPO have been teamed with MSX International since February 2002. Mark Stewart
direction hanging playing stage together
We've always been friends before we were even in a band. It's a good-natured feeling, playing together on stage every night. To us, hanging out is playing a show. We can read each other and know each other's moods, and we know the direction we're headed. But we also know nothing is set in stone. Chris Culos
direction front job quite
There are some encouraging signs. They're going in the right direction. Still, they've got quite a job in front of them. Stuart Fraser
direction negative pulling start
When you start pulling out infrastructure that's been there over 100 years, that's a negative direction to be heading. Jon Tester
direction good growing number state voters
We have a state where a growing number of voters are displeased with the direction of the state. If that's not a good set-up for a third-party candidate, I don't know what is. Tim Hibbitts
direction hooked people point whatever
We've been able to point people in the right direction and get them hooked up with locations, crews, whatever they need. Tim Clark
direction federal waiting
We're just waiting for direction from the federal level. Kelly Brown
direction moving starting
We're moving in the right direction. We're starting to get a lot of momentum. Matt Haryasz
direction hope moving
We're moving in the right direction. At this point, that's all we can hope for. Charles Turner
keys people words-of-wisdom
If a dread of not being understood be hidden in the breasts of other young people to anything like the extent to which it used to be hidden in mine - which I consider probable, as I have no particular reason to suspect myself of having been a monstrosity - it is the key to many reservations. Charles Dickens
keys imagination mind
A vile imagination, once indulged, gets the key of our minds, and can get in again very easily, whether we will or no, and can so return as to bring seven other spirits with it more wicked than itself; and what may follow no one knows. Charles Spurgeon
keys beggary idleness
Idleness is the key of beggary. Charles Spurgeon
keys incomplete-knowledge choices
Given our inevitably incomplete knowledge about key structural aspects of an everchanging economy and the sometimes asymmetric costs or benefits of particular outcomes, a central bank needs to consider not only the most likely future path for the economy but also the distribution of possible outcomes about that path. The decision makers then need to reach judgment about the probabilities, costs and benefits of the various possible outcomes under alternative choices for policy. Alan Greenspan
keys risk resilience
The use of a growing array of derivatives and the related application of more-sophisticated approaches to measuring and managing risk are key factors underpinning the greater resilience of our largest financial institutions .... Derivatives have permitted the unbundling of financial risks. Alan Greenspan
keys parent seven
When I was 12, I forgot the keys to my parent's apartment. So I simply climbed up seven floors to get in. Alain Robert
keys boots way
I was very, very shocked about Cooperstown. I thought my chances were fairly good, but I tried to stay low key about it, not too high and not too low. That was the way I played, too. Al Kaline
keys mind obedience
The KEY to disciplining ourselves in the area of obedience is always keeping in mind to whom we are being obedient. Aiden Wilson Tozer
keys guy albums
I just downloaded the new Alvin and the Chipmunks album! They're the only guys that make music in my key! Chris Colfer
plants-growing shining desire
You do not have to force yourself to do anything at all. There is a continual exchange, a continual dance. It is similar to the sun shining and plants growing. The sun has no desire to create the vegetation; plants simply react to sunlight and the situation develops naturally. Chogyam Trungpa
plants
The plants are in a weakened state. Moisture is the key. We need rain. Mark Ploger
plants putting
I wouldn't be putting out young plants just yet. Mark Wiley
plants upgrade
There aren't very many hydro plants we can upgrade left. Jim Leonard
plants
When they say plants are closing, they're going elsewhere. And it's not just China; it's Tennessee, Texas, more business-friendly states. Vince Green
plants somebody suspected time
We never thought or suspected that these plants would have a problem. Somebody should be doing time for this; that's the way I look at it. Paul Anderson
plants-growing tree shade
Our moral faculties must be placed highest, else they can no more flourish than could a plant growing under the shade and drip of trees. Henry Ward Beecher
plants rare strange
Rare plants are rare because they've got strange habits. Elaine Nash
plants shut
A lot of plants will shut down if there is no relief. Roger Schagrin
power overcoming cowardice
That cowardice is incorrigible which the love of power cannot overcome. Charles Caleb Colton
powerful weak said
The worst thing that can be said of the most powerful is that they can take your life; but the same can be said of the most weak. Charles Caleb Colton
power two age
There are three kinds of power,--wealth, strength, and talent; but as old age always weakens, often destroys, the two latter, the aged are induced to cling with the greater avidity to the former. Charles Caleb Colton
powerful forgiving easy
It is more easy to forgive the weak who have injured us than the powerful whom we have injured. Charles Caleb Colton
powerful heaven goddess
We make a goddess of Fortune ... and place her in the highest heaven. But it is not fortune that is exalted and powerful, but we ourselves that are abject and weak. Charles Caleb Colton
powerful heart vanity
Vanity finds in self-love so powerful an ally that it storms, as it were, by a coup de main,, the citadel of our heads, where, having blinded the two watchmen, it readily descends into the heart. Charles Caleb Colton
powerful lying believe
One of Satan's most deceptive and powerful ways of defeating us is to get us to believe a lie. And the biggest lie is that there are no consequences to our own doing. Satan will give you whatever you ask for if it will lead you where he ultimately wants you. Charles Stanley
powerful evil spirit
We declare, upon Scriptural authority, that the human will is so desperately set on mischief, so depraved, and so inclined to everything that is evil, and so disinclined to everything that is good, that without the powerful, supernatural, irresistible influence of the Holy Spirit, no human will ever be constrained towards Christ. Charles Spurgeon
powerful church christ
In proportion as a church is holy, in that proportion will its testimony for Christ be powerful. Charles Spurgeon
steps backing-up steady
History has spurts and then is steady, and then maybe even backing up a step, and then forward again. Alan Bean
step
We want to take a step forward. There's some worries. But you just go in there and play. David Cornwell
steps surprise reader
I really like it when you can step outside of what's come before and find a surprise for the reader and find a surprise for yourself. Dave Gibbons
steps tough push-yourself
You take yourself to a place where you've got absolutely nothing left and then you find out you have to push yourself one more step. That's a tough place to be in. Bryan Clay
steps comfort grows
It is only when You really STEP OUT of Your comfort zone that You GROW. Bear Grylls
steps problem illegal
Illegal immigrants are already a very big problem for us. We are already taking big steps to disallow illegal immigrants from coming in. Antonis Samaras
steps commencement experiments
One failed experiment is one step closer to Success Denzel Washington
steps should
Until we see what we are, we cannot take steps to become what we should be. Charlotte Perkins Gilman
steps looks hard
It's hard to see things when you're too close. Take a step back and look. Bob Ross
technology hands people
Technology is destructive only in the hands of people who do not realize that they are one and the same process as the universe. Alan Watts
technology civilization goal
...the materialism of modern civilization is paradoxically founded on a hatred of materiality, a goal-oriented desire to obliterate all natural limits through technology, imposing an abstract grid over nature. Alan Watts
technology fit lifestyle
The success of SYNC is another proof point that we are doing just that. We will continue to innovate and expand the capability of SYNC by integrating even more new technologies that fit our customers’ lifestyles. Alan Mulally
technology matter watches
It doesn't matter what the technology is - no one will watch a Peter Greenaway film anyway. Alan Parker
technology fields needs
The computing field is always in need of new cliches. Alan Perlis
technology thinking people
I think it is inevitable that people program poorly. Training will not substantially help matters. We have to learn to live with it. Alan Perlis
technology bird worms
In software systems it is often the early bird that makes the worm. Alan Perlis
technology two benefits
Technology is always a two-edged sword. It will bring in many benefits, but also many disasters. Alan Moore
technology amish kind
I'm remote from most technology to the point that I'm kind of Amish. Alan Moore